ADRENERGIC RECEPTOR AGONIST AND ANTAGONIST

Question 1

What do adrenoreceptors do

Answer 1

Adrenoceptors mediate central and peripheral actions of NA (NT) & Adr. (hormone & NT).

Question 2

Where are adrenoceptors found

Answer 2

Found in nearly all peripheral tissues & on many neuronal populations within the CNS.

Question 3

Functions of adrenoceptos agonist and antagonist

Answer 3

 Agonists & antagonists have proved useful in treatment of variety of diseases including hypertension, angina pectoris, CHF, asthma, depression, BPH & glaucoma.
 Also useful in therapeutic situations e.g. shock, premature labour, opioid withdrawal & as adjuncts to general anaesthesia.
AJA

Question 4

What are the types of adrenoreceptors

Answer 4

α , β
α1, α2
β1 , β2 , β3 , β4
α2A , α2B , α2C , (α2D)
α1A , α1B , α1D , (α1L)

Question 5

What is α2D

Answer 5

α2D is a species orthologue of the human α2A subtype hence it is not considered to be a separate subtype

Question 6

What is α1L

Answer 6

α1L may represent a particular conformational state of the α1A-ADR.

Question 7

What tissues are alpha1 receptors found and what’s the effect

Answer 7

• Most vascular smooth muscle ;contract (vascular resistance)
• Pupillary dilator muscle ; contract (mydriasis)
• Pilomotor smooth muscle ; contract (erects hair)

Question 8

What tissues are alpha 2 receptors found and their effect

Answer 8

Adrenergic and cholinergic nerve terminals (inhibit transmitter release)
Platelets
Some vascular smooth muscle

Question 9

What’s the distribution of the adrenergic receptors

Answer 9

Alpha 1: almost all effectors
Alpha 2: preganglionic neuron
Beta 1: heart
Beta 2: almost all effectors
Beta 3: adipocytes

Question 10

What are the distribution of the adrenergic receptors

Answer 10

Alpha 1: Gq
Alpha 2: Gi
Beta 1-3: Gs

Question 11

What adrenergic receptor controls the eyes and it’s effect

Answer 11

Alpha1, beta 2
Myadriasis (pupillary dilatation)

Question 12

What adrenergic receptor controls the salivary gland and it’s effect

Answer 12

Alpha 1, beta 2
Thick mucus saliva

Question 13

What adrenergic receptor controls the lungs and it’s effect

Answer 13

Beta 2
Bronchodialtion

Question 14

What adrenergic receptor affects the heart and it’s effect

Answer 14

Beta 1
Increased HR and FC

Question 15

What adrenergic receptor affects the GIT and it’s effect

Answer 15

Alpha 1 Beta 2
Reduced motility and increased feacal retention

Question 16

What adrenergic receptor affects the urinary tract and it’s effect

Answer 16

Alpha 1 Beta 2
increased urinary retention

Question 17

What adrenergic receptor affects the Liver and it’s effect

Answer 17

Beta 2 and alpha 1
Glycogenolysis

Question 18

What adrenergic receptor affects the kidney and it’s effect

Answer 18

Beta 2
Stimulation of RAAS

Question 19

What adrenergic receptor affects fat and it’s effect

Answer 19

Beta 3
Lipolysis

Question 20

What adrenergic receptor affects the genitals and it’s effect

Answer 20

Alpha 1(male) Beta 2(female)
Ejaculation

Question 21

I’m the GIT, which adrenergic receptor affects GIT wall and sphincter specifically

Answer 21

Beta 2 - wall
Alpha 1- sphincter