Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

D&T2 Exam 1 > Cholinergic Pharmacology > Flashcards

Cholinergic Pharmacology Flashcards

1
Q

Bethanechol

A

Muscarinic receptor agonist

Urinary retention
Reverse postoperative abdominal distension
Reverse gastric atony or stasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Carbachol and Pilicarpine

A

Muscarinic receptor agonist

Glaucoma- decrease intraocular pressure

Induce miosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Methacholine

A

Diagnosis of airway hyperreactivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Homatropine

A

Muscarinic receptor antagonist

Ophthalmologic examination
Mydriatic effects promote examination of retina and optic disk
Cycloplegic effects facilitate measurement of refractive errors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Atropine

A

Muscarinic receptor antagonists

Used to reverse muscarinic poisoning and peripheral muscarinic effects of Cholinergic agents

Toxic doses will cause CNS stimulation, even higher doses will cause CNS depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Glycopyrrate

A

Muscarinic receptor antagonist

Suppresses peripheral muscarinic effects of cholinergic agents such as neostigmine and pyridostigmine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Benztropine and Truhextphenidyl

A

Muscarinic receptor antagonists

Parkinsonism, extrapyramidal disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Scopolamine

A

Muscarinic receptor antagonist

Prophylactic treatment of motion sickness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Succinylcholine

A

Depolarizing NMJ blocking drug

Nicotinic receptor agonist

Stays bound to nicotinic receptor- leads to muscle relaxation

Can cause malignant hyperthermia
Can cause hyperkalemia- cardiac arrest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Dantrolene

A

Blocks Ca2+ release from sarcoplasmic reticulum and relaxes skeletal muscle

Used to treat malignant hyperthermia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Nicotine

A

Low dose stimulates nicotinic receptor

High dose will first induce Nn and Nm but is followed by a depolarization block at Nn and Nm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Reversible anticholinesterases

A 
Edrophonium
Physostigmine
Pyridostigmine
Tacrine
Donepezil
Rivastigmine

Compete with ACh anionic site

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Neostigmine

A

Anticholinesterase

Carbamylate esteratic site

Slow hydrolysis of the carbamylating drug by AChE will lead to increase ACh

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Organophosphate inhibitors

A

Isoflurophate, echothiophate, insecticides, nerve gases

Phosphorylate esteratic site- irreversible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Edrophonium

A

Anticholinesterase

Quaternary ammonium
Rapid onset and short duration

Myasthenia gravis: diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Neostigmine

A

Anticholinesterase

Quaternary amine with long duration of action

Myasthenia gravis

17
Q

Physostigmine, tacrine, rivastigmine

A

Anticholinesterases

Lipophilic- cross BBB

Physostigmine: glaucoma
Rivastigmine: Alzheimer’s disease

18
Q

Organophosphate anticholinesterase

A

Lipid soluble- cross BBB

Echothiophate and isoflurophate: glaucoma

19
Q

Pralidoxime

A

Cholinesterase reactivator

Reactivate acetylcholinesterase following organophosphate acetylcholinesterase poisoning

Pull organophosphate off AChE

D&T2 Exam 1 (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions