Cholinergic Drugs Flashcards
Muscarinic receptor binding drug that increases salivary flow
Pilocarpine
Pilocarpine has three uses - what are they?
- Increase salivary flow
- Increase aqueous humor outflow
- Treats glaucoma
Muscarinic receptor binding: direct-acting, agonist drugs. (2)
Pilocarpine + Muscarine
Reversible anti-cholinesterase drugs. (3)
- Pyridostigmine
- Physostigmine
- Neostigmine
Toxic alkaloid from certain types of mushrooms
Muscarine
Mechanism of action for the three reversible anti-cholinesterase drugs.
Block the cholinesterase enzyme, which results in increase ACh levels
Reverses severe cholinolytic toxicity
Physostigmine
What two drugs can be used to treat myasthenia graves?
Pyridostigmine
Neostigmine
Irreversible anti-cholinesterase drug?
Agent VX
Mechanism of action for Agent VX?
Block the cholinesterase enzyme by binding to it irreversibly, which results in prolonged increased ACh levels
Two antagonist; muscarinic, non-selective; direct drugs?
Atropine + Scopolamine
Antidotes for Agent VX?
- Atropine
- Pralidoxime
Drug that is Anti-diarrhea and also causes mydriasis (pupils to dilate)?
Atropine
biphasic = ?
Nicotine
Discuss biphasic nicotine?
- Low doses = stimulates ganglionic receptors
- High doses = inhibit ganglionic receptors
Blocks both SNS and PNS
Nicotine
Reduces predominant tone
Nicotine
At low dose of nicotine, what happens to blood pressure?
increases
Nicotine is a cholinergic ____ at low doses
agonist
Nicotine is a cholinergic ___ at high doses
antagonist
