Cholinergic Drugs

Question 1

Varenicline

Answer 1

• smoking cessation

- nicotinic agonist

Question 2

Succinylcholine

Answer 2

• muscle relaxant

- nicotinic agonist

Question 3

Bethanechol

Answer 3

• post-op ileus

- muscarinic M3 agonist

Question 4

Pilocarpine

Answer 4

• Sjorgren’s syndrome (helps with dry mouth)

- muscarinic agonist

Question 5

Atropine

Answer 5

• topical for eye or reversal of cholinergic toxicity

- muscarinic antagonist

Question 6

Scopolamine

Answer 6

• topical for eye

- muscarinic antagonist

Question 7

Tropicamide

Answer 7

• topical for eye

- muscarinic M3 antagonist

Question 8

Benztropine

Answer 8

• parkinson’s tx

- muscarinic antagonist

Question 9

Ipratropium

Answer 9

• COPD

- muscarinic antagonist

Question 10

Tolterodine

Answer 10

• incontinence

- muscarinic M3 antagonist

Question 11

Edrophonium

Answer 11

• diagnostic tool for MG

- short-acting Achesteraase inhibitor

Question 12

Neostigmine

Answer 12

• tx for MG, ileus, reversal of neuromuscular blockade

- intermediate-acting inhibitor of Achesterase (0.5-2 hr)

Question 13

Pyridostigmine

Answer 13

• tx for MG

- intermediate-acting Achesterase inhibitor (3-6 hr)

Question 14

Ambenonium

Answer 14

• tx for MG

- intermediate-acting Achesterase inhibitor (4-8 hr)

Question 15

Demecarium

Answer 15

• tx for glaucoma

- intermediate-acting Achesterase inhibitor (4-6 hr)

Question 16

Physostigmine

Answer 16

• tx for glaucoma
• intermediate-acting Achesterase inhibitor
• only drug in this class that crosses BBB

Question 17

Rivastigmine

Answer 17

-derivative of physostigmine, tx for AD

Question 18

Pralidoxime

Answer 18

• antidote for cholinergic toxicity, can be given repeatedly during first 48 hours of exposure
• interacts with acetylcholinesterase blocking agent