Cholinergic Drug Lec. 2

Question 1

What name drug Anti muscarinic: non-selective and Natural alkaloids?

Answer 1

1-atropine
2-scopolamin
سكوبول امين

Question 2

What name drug Anti muscarinic M1 selective

Answer 2

Pirenzepine

Question 3

What drug Semisynthetic Muscarinic antagonist

Answer 3

Homatropine; Hyoscine butylbromide ;Ipratropium; Tiotropium

Question 4

Muscarinic antagonist for Mydriatics?

Answer 4

Cyclopentolate; Tropicamide

Question 5

What Synthetic drug for Vasicoselective

Answer 5

oselective : Oxybutynin; Flavoxate; Tolterodine; Darifenacin; Solifenacin

Question 6

What Synthetic drug for Antisecretory (antispasmotic)

Answer 6

Quaternary comps :Propantheline; Tertiary amines : Dicyclomine;

Question 7

What Muscarinic-receptor antagonists are tertiary amine alkaloids

Answer 7

e.g., atropine, scopolamine

Question 8

Wheaten Muscarinic-receptor antagonists are quaternary amines

Answer 8

g., propantheline, ipratropium

Question 9

What Drug that Used ophthalmoscopic examination of the retina?

Answer 9

Shorter-acting muscarinic-receptor antagonists (e.g., homatropine and tropicamide, cyclopentolate) produce mydriasis are administered topically as eye drops. B.iridocyclitis,inflamed iris is a raw surface it will adhere ant to cornea(anterior synaechiae ) or posteriorly to the lens (post. Synaechiae) which need operation so here we give atropine to retract the iris to the back

Question 10

What’s drugs Used for ophthalmoscopic examination of the retina and was
Shorter-acting muscarinic-receptor antagonists and produce mydriasis are administered topically as eye drops?

Answer 10

homatropine and tropicamide, cyclopentolate

Question 11

Whate the drug use in operation of B.iridocyclitis,inflamed iris is a raw surface it will adhere ant to cornea(anterior synaechiae ) or posteriorly to the lens (post. Synaechiae)?

Answer 11

atropine to retract the iris to the back

Question 12

What the drug that use for Cardiovascular system uses include the administration of these drugs as a
treatment for acute myocardial infarction with accompanying bradycardia and hypotension or arrhythmias ?

Answer 12

atropine

Question 13

What are drugs can be used to suppress bronchiolar secretions during surgical and spinal anesthe

Answer 13

Atropine and scopolamine

Question 14

What the drugs are used as an inhalant to treat reactive airway disease such as asthma and chronic obstructive pulmonary disease (COPD).

Answer 14

Ipratropium (4 h up to 4 times daily)and tiotropium (24h once daily)

Question 15

Whate the drugs are used as an antispasmodic agent to relax the GI tract and bladder.Also used in irritable bowel syndrome

Answer 15

atropine & hyoscine butylbromide

Question 16

Whate drug selective M1 blocker inilially used in therapy of peptic ulcer but it was weak ( why) & with the appearance of new drugs( H2 antihistamine, Proton pump inhibitors) its use in therapy of peptic ulcer was stopped.

Answer 16

Pirenzepine

Question 17

Any drugs drugs for symptomatic treatment of urinary urgency& frequency in inflammatory bladder disorder(cyctitis)
And increase bladder capacity & decrease its pressure

Answer 17

Oxybutynin(بدايتو اوكسي من الاوكسيميتر ) ,flavoxateبدايتو فلا من فلا اوت علاج انفلونزا )

Question 18

What is drugs for Urinary incontinence selective M3-receptor antagonists selective for M3 receptor in the U-sphincter.

Answer 18

Tolterodine
بدايتو تذكرني بكلمة توالت

Question 19

What are drugs used orally, intravenously, or transdermally) prevents motion sickness by blocking muscarinic receptors in the vestibular system and in the CNS and also has additional amnestic and sedative properties so used preoperatively.

Answer 19

Scopolamine

Question 20

What are drugs used as adjunct to levodopa
therapy for some patients with Parkinson disease(helpful in reducing salivation,spasticity & tremors), and in dryg-induced extrapyramidal reactions e.g antipsychotic

Answer 20

Antimuscarinic drugs, benztropine بدايتو تذكرني بالبنزين ،benzhexol, trihexyphenidyl بدايتو تذكرني بالبادئة ترا الي معناها ثلاثة,

Question 21

What are Contraindications of atropine

Answer 21

Glaucoma; BPH;GIT obstraction;Tacharrhythmias & angina; Hyperthyoidism; infectious diarrhea

Question 22

What are occur in Toxicity of Anticholinergics and who are treatment

Answer 22

Hyperthermia,Dry mouth, Tachycardia, Urinary retention, Paralytic ileus, Seizure, Coma
Treatment: Gastric lavage
Cold sponging; Physostigmine SC or IV Diazepam if there is convulsion

Question 23

What are drug use for Ganglion blocking agents( Pass BBB,long duration of action ,given orally, not causing histamine release) and other ganglion-blocker were extensively used in the treatment of hypertension ,but unfortunately , the adverse effect of ganglion blocked are so sever (both sympathetic and parasympathetic divisions are blocked), that patients are unable to tolerate long term treatment with them.

Answer 23

hexamethionin, mecamylamine

Question 24

What are Drugs use for Ganglion-blocker still in clinical use its poorly lipid soluble inactive orally and has a short half-life it is used only I.V to treat sever accelerated hypertension (malignant hypertension) and to produce controlled hypotension. Causes histamine release.

Answer 24

Trimethaphan