Cholinergic drug Flashcards
explain the types of muscarinic receptors
M1- CNS ,Salivary gland, Gastric Gland
M2-Het, GIT, CNS
M3-Gastric Gland, Salivary Gland, eye, GIT
List the cholinesterase inhibitor drugs
Neostigmine, Physostigmine, Pyridostigmine, Edrophonium
Describe Neostigmine: mechanism, treatment and adverse effects
-Carbamate cholinesterase inhibitor
-Bowel and bladder movement: increased motility and relaxation of sphincters.
-Treatment
1-bowel/bladder-decreased HR, contraction, AV node conduction.
Adverse- xs cholinergic stimulation
Describe Physostigmine: mechanism, treatment and adverse effects
-Non-carbamate ACH inhibitor
-Treatment-MG, Anticholinergic toxicity, overdose of Atropine
-Adverse: Convulsions, muscle paralysis, cholinergic stimulation.
Describe Pyridostigmine: mechanism, treatment and adverse effects
-Similar to Neo & Edro to treat Myasthenia Gravis.
-treatment- long term treatment of MG.
Adverse- cholinergic stimulation.
Describe Edrophonium: mechanism, treatment and adverse effects
-Non carbamate ACH inhibitor.
-Treatment
1- use to diagnose MG
2- differentiat between MG and cholinergic crisis.
Adverse: cholinergic stimulation.
What are Organophosphates?
Irreversible Anticholinesterase
what is organophosphates used for?
respiration
high doses of Atropine
describe Scopolamine
Cholinergic antagonist
muscarinic blocker
Activated by ACH
Treatment-motion sickness, vomiting
blocks CNS
Describe Atropine
Cholinergic antagonist
CNS-restlessness, hallucinations
CVS-Decreased HR, tachycardia
GIT- decreased salivary gland secretions
nuff tings atp
Adverse effects of Atropine
Red as a beet, blind as a bat, dry as a bone, hot as a snare, mad as a hatter
treatments of Atropine
bradycardia, Mydriasis, Gastrointestinal spasms, Organophosphate poisoning.
List some antimuscarinics
Oxybutynin competitive muscarinic
Ipratropium- non selective antagonist
