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CPR2 Exam 1 > Cholinergic Agonists And Antagonists - Dr. Kruse > Flashcards

Cholinergic Agonists And Antagonists - Dr. Kruse Flashcards

1
Q

M1 location

A

nerves

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2
Q

M2 location

A

heart, SM, nerves

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3
Q

M3

A

glands, SM, Endothelium

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4
Q

M4 location

A

CNS

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5
Q

M5 location

A

CNS

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6
Q

Nn location

A

Post-ganglionic cell body, dendrites, CNS

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7
Q

Nm location

A

skeletal muscles neuromuscular junction

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8
Q

eye contraction receptor

A

M3 and M2 = constriction of pupil by contracting sphincter of iris + ciliary muscle

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9
Q

lung Rs

A

M2 and M3 (bronchoconstriction)

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10
Q

GIGU Rs

A

M2 + M3

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11
Q

Direct -acting cholinergic agonists metabolized by what

A

acytylcholinesterase

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12
Q

nicotinic vs muscarinic R and absorption

A
  1. Nicotinic : uncharge and highly absorbed

2. Muscarinic : charged, highly absorbed

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13
Q

Direct -acting cholinergic agonists 4

A
  1. Ach
  2. Methacholine
  3. Carbachol
  4. Bethanechol
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14
Q

indirect-acting cholinergic agonists do what and 3 types

A

increase Ach

  1. alcohols (reversible)
  2. Carbamic acid esters (reversible)
  3. Organophosphates (irreversible)
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15
Q

Indirect -acting cholinergic agonists and absorption

A

alcohol + carbamic acid esters = charges + poorly absorbed

Organophosphates = uncharged and absorbed

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16
Q

parasympathetic affect on bladder

A

relax sphincter

contraction of detrusor

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17
Q

parasympathetic effect on sweat glands

A

secretion

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18
Q

parasympathetic stimulation on bronchial glands

A

stimulate

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19
Q

main uses for direct -acting cholinergic agonists

EYE

A
  1. glaucoma

2. esotropia (hypermetropic accomodative error)

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20
Q

main uses for direct -acting cholinergic agonists

GIGU

A
  1. post-ileus
  2. congenital megacolon
  3. urinary retention
  4. esophageal reflux
  5. Xerostomia , Sjögren syndrome
21
Q

muscarinic stimulatants Side effects

A

N, V, D, urinary urgency, salvation, sweating, increase in glandular secretion = SLUDGE

22
Q

muscarinic stimulants are contraindicated in

A
  1. asthma
  2. hyperthyroidism
  3. coronary insufficiency
  4. acid-peptic disease
23
Q

Nicotine stimulants side effects

A
  1. nicotine poisoning : from cigs and insecticides

2. acute toxicity : CNS, skeletal muscle end plate depolarization , resp paralysis, htn, cardiac arrhythmias

24
Q

tx side effects of direct -acting cholinergic agonists

A
  1. atropine

2. parenteral anticonvulsants (diazepam a benzodiazepine)

25
Q

Acetylcholine is for what

A

intraocular during surgery = miosis (constriction of pupil)

26
Q

Bethanechol is used for what

A
  1. urinary retention (can cause UTI if sphincter does not relax)
  2. heartburn
27
Q

Carbachol is used for

A
  1. glaucoma
  2. intraocular surgery for miosis
  3. opthalmic examination
28
Q

Cevimeline used for

A

dry mouth in sjögrens syndrome

29
Q

Pilocarpine used for

A
  1. dry mouth in sjögrens syndrome, head/neck cancer
  2. miosis during surgery
  3. glaucoma
30
Q

Varenicline (Chantix) MOA and for who

A
  1. stimulation and moderate release of mesolimbic dopamine (bind to Nn)
  2. for smoking cessation
31
Q

Varenicline (Chantix) adverse effects

A

neuropsychiatric sx, agitation, depression, dark behavior

32
Q

Indirect- acting cholinergic agonists main 6 uses

A
  1. Glaucoma
  2. Dementia
  3. Antidote to anticholinergic poisoning
  4. reversal of neuromuscular paralysis
  5. myasthenia gravis
  6. Ach.esterase inhibitor toxicity
33
Q

Ach.esterase inhibitor toxicity sx

A

SLUDGE SX, EFFECTS NMJ, TX WITH ATROPINE

34
Q

glaucoma and mAchR stimulation

A

aqueous humor outflow and reduces intraocular P

35
Q

anticholinergic poisoning sx and from what

A
  1. vasodilation cutaneous , anhidrosis, hyperthermia, mydriasis, delirium, X urination
  2. atropine, anti-histamines, TCA, sleep aids,
36
Q

most common cholinergic antagonist

A

atropine

37
Q

anticholinergic agents 7 uses

A
  1. motion sickness
  2. GI
  3. dilation eye
  4. respiration problems
  5. urinary problems
  6. cholinergic poisoning
  7. movement disorder
38
Q

parkinsons disease drug to help

A

anti-cholinergic = reduce tremors, most effective is standard dopamine tx

39
Q

motion sickness drug

A

anticholinergic agents = scopolamine

40
Q

anesthesia

A

anticholinergic = atropine blocking vagal reflexes, from surgical manipulation of organs
= given with neostigmine (AchE Inhibitor)

41
Q

when do you need anticholinergic on eye

A

prolonged eye dilation in
1. LASIK surgery,
(a-adrenergic receptor agonist is shorter acting and less adverse effects)
2. uveitis and iritis prevention

42
Q

lungs and anticholinergic agents

A
  1. Ipratropium and tiotropium

2. for COPD mostly and asthma

43
Q

anticholinergic agents and GI

A

travelers D, Lomotil (atropine + diphenoxylate)

44
Q

anticholinergic agents GU

A
  1. urinary urgency (minor inflammatory bladder disorder)

2. agents acting on M3**

45
Q

4 drugs acting on M3 for the GU

A
  1. oxybutynin : dry sx side effects
  2. Darifenacin
  3. Solifenacin
  4. Tolterodine
46
Q

insectacide poisoning does what and how to tx

A

cholinesterase inhibitor
=tx with anticholinergics (anti-Muscarininc = ATROPINE)
= no effect is you treat with anti-nAchR (pralidoxime)

47
Q

anticholinergic agents adverse effects

A
  1. dry as a bone
  2. blind as a bat
  3. red and beet
  4. mad as a hatter
  5. hot has a hare
48
Q

anticholinergic agents contraindicated in what 3 pts

A
  1. glaucoma
  2. prostatic hyperplasia
  3. acid-peptic disease

CPR2 Exam 1 (19 decks)

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