Antiadrenergic Drugs Part 2 - Dr. Konorev

Question 1

Direct Antiadrenergic drugs

Answer 1

1. A adrenoreceptor antagonist
   - non-selective (a1 and a2)
   - a1 selective
2. Mixed blockers (B and a1)
3. B adrenoreceptor blockers
   - B1 and B2
   - B1 selective

Question 2

Indirect Antiadrenergic drugs

Answer 2

1. NE release inhibitor

2. Tyrosine Hydroxylase inhibitor

Question 3

Non-selective a1 and a2 receptor antagonist

2

Answer 3

1. Phenotolamine

2. Phenoxybenzamine

Question 4

A1 selective R antagonist

3

Answer 4

1. Prazosin
2. Tamsulosin
3. Doxazosin

Question 5

Mixed blockers

2

Answer 5

1. Labetalol : B and a1 antagonist

2. Carvedilol : B and a1 antagonist

Question 6

B R blockers : B1 and B2

3

Answer 6

1. Propranolol
2. Pindolol
3. Ndolol

Question 7

B R blockers : B1 selective

4

Answer 7

1. Metoprolol
2. Betaxolol
3. Acebutolol
4. Atenolol

Question 8

NE release inhibitor

1

Answer 8

Guanethidine

Question 9

Tyrosine Hydroxylase inhibitor

1

Answer 9

Metyrosine = inhibit synthesis of NTs

Question 10

Phentolamine what type of drug and HL

Answer 10

Reversible competitor , non-covalent binding
Short half life
You can reverse by giving antagonist to it

Question 11

Phenoxybenzamine type of drug and HL

Answer 11

Non-competitive irreversible , covalent binding

Longer H

Question 12

Miosis

Answer 12

Pupil constriction (pupil dilator muscle relaxes)

Question 13

Most seen thing in a antagonist effect

Answer 13

Lower BP

= can cause Tachycardia as body responds

Question 14

TX phenochromocytoma ( adrenal gland tumor, making catecholamines)

Answer 14

Phentolamine, phenoxybenzamine, metyrosine

Question 15

TX Chronic HTN

Answer 15

Prazosin, doxazosin (a1 selective)

Question 16

TX erectile dysfunction

Answer 16

Phentolamine + vasodilator

Question 17

TX benign prostate hyperplasia (BPH)

Answer 17

= treats chronic urinary obstruction (incontinence)

Tamsulosin (A1a)——> prevent prostate SM contraction without decrease in BP

Question 18

Some adverse effects of a antagonist drugs

Answer 18

Tachy
Nasal stuffiness
Postural hypotension = body response 
Fluid retention = body response
X ejaculation

Question 19

B1 selective antagonist other name

Answer 19

Cardiac selective

= heart has B1 only

Question 20

Antagonists B blockers

Answer 20

Atenolol
Nadolol
Propranolol

Question 21

Partial antagonist B blockers

Answer 21

Acebutolol
Labetalol
Pindolol

Question 22

Inverse agonists

Answer 22

Betaxolol

Metoprolol

Question 23

Partial Agonist : beta-blockers use and other name

Answer 23

ISA : Intrinsic Sympathomimetic activity B-blockers

= good for pt who has HTN + low HR, this drug can decrease BP and not have as much decrease on HR

Question 24

Beta blockers main effects
Heart
BVs
Kidney

Answer 24

1. Slow HR , force and AV conduction
2. Initially increase BV constriction and then decrease it when long-term use
3. Inhibits renin release

Question 25

Beta blockers main effects
Lungs
Eye
metabolism

Answer 25

1. Increase airway resistance
2. Reduce aqueous humor = lower intraocular pressure
3. X lipolysis, increase VLDL, X glycogenolysis + gluconeogenesis

Question 26

5 conditions Beta-blockers are used for heart related

Answer 26

1. Chronic HTN
2. Angina Pectoris
3. MI
4. Cardiac Arrhythmia (ventricular and supraventricular, atrial fib or flutter, V ectopic beats)
5. Heart Failure : Metoprolol and carvedilol (not for congestive HF)

Question 27

2 conditions Beta-blockers are used for NOT heart related

Answer 27

1. Glaucoma : Betaxolol (also has anesthetic activity)

2. Hyperthyroidism : Propranolol

Question 28

B1 2 main functions

Answer 28

Increase HR and increase RENIN

Question 29

Adverse effects of B-blockers 5 and what to do

Answer 29

1. CNS effects : depression, sleep problems (switch to most hydrophilic drug)
2. Resp bronchospasm or asthma, airway resistance (switch to B1 selective)
3. Cardiac depression (switch to partial antagonist)
4. Low cholesterol from decrease in HDL (switch to partial antagonist)
5. Hypoglycemia in DM (switch to B1 selective)

Question 30

Abrupt discontinuation of B-blockers can cause what

Answer 30

Cardiac problems from sympathetic hyper-responsiveness =arrhythmia , ischemic heart disease,
= during drug of B-blocker ——> body compensated by increasing B receptors on the neurons ——> super stimulation when drug is removed