Cholinergic Agonists

Question 1

Acetylcholine

Answer 1

Miosis (not important)

Question 2

Bethanecol

Answer 2

Stimulation of bladder tone

SE: sweating, decrease BP, nausea, abdominal pain, diarrhea, bronchospasm

Question 3

Carbachol

Answer 3

Rarely used, decreased IOP (Miosis), acute ACG, Pigmentary glaucoma, Sx
SE: Bronchial constriction
CI: Uveitis, Undesirable Miosis

Question 4

Pilocarpine

Answer 4

DOC for IOP reduction in glaucoma tx (emergency), Acute ACG, OAG, Secondary glaucoma SE: Accommodative spasm
CI: pts. under 40 y/o, cataracts, asthma, neovascular & uveitis glaucoma, Hx of retinal detachment

Question 5

Reversible: Physostigmine

Answer 5

Atony of intestines & bladder by motility, decreased IOP (topical), overdose of atropine, phenothiazine, TCAs
SE: convulsions, bradycardia

Question 6

Reversible: Pyridostigmine

Answer 6

Myasthenia Gravis

SE: convulsions, bradycardia

Question 7

Reversible: Neostigmine

Answer 7

Myasthenia Gravis

Question 8

Reversible: Demecarium

Answer 8

OAG

Question 9

Reversible: Edrophonium

Answer 9

Dx of Myasthenia Gravis

Does not cross BBB

Question 10

Reversible: Tacrine, Donazepil, Rivastigmine, Galantamine

Answer 10

Alzheimer’s disease

Question 11

Irreversible: Echothiopate

Answer 11

Ophthalmic ointment for chronic OAG, POAG, ACG, Accommodative esotropia
Caution: pesticides & insecticides

Question 12

Irreversible: Pralidoxime

Answer 12

reactivation of acetylcholinesterase but must be used before aging.