Cholera

Question 1

Cholera spread

Answer 1

Fecal contaminated drinking water
HIGH INNCOLUM

little P2P transmission

Question 2

Cholera caused by

Answer 2

Vibrio Cholerae

Question 3

Cholera Distribution

Answer 3

DISASTER PANDEMICS

lack of clean water

Question 4

Cholera manifestations

Answer 4

RICE WATER STOOL

1L / hr

Question 5

Cholera Stages

Answer 5

Incutbation: 5-7 days

Question 6

Cholera Classifications

Answer 6

Gram(-) vibrio

O-1 and O-139

Question 7

Cholera toxin

Answer 7

ctx A-B

Perturbs adenylate cyclase
electrolyte imbalance

result of double lysogeny

Question 8

Cholera double lysogeny

Answer 8

Only strains with tcp (receptor) and ctx (toxin) genes produce cholera disease.
Both genes are added by phages and the receptor gene is needed for the CTX virus to get in to add the toxin DNA

Question 9

Vibrio ID

Answer 9

TCBS

needs basic, salty environment

oxidase (+)
distinguishes from E.coli

Question 10

Rapid test for cholera

Answer 10

andtibodies for O-1 and O-139

NOT ALL CHOLERA species CONTAIN TOXIN GENE

Question 11

Cholera Treatment

Answer 11

exotic foods, don’t take antacids

vaccines:
- dukoral (toxoid)
(also helps with travelers diarhhea)
- shachol (killed whole cells)
(very cheap to produce)

Prophylactic: Tetracyclines

Question 12

V. parahaemolyticus

Answer 12

Most common foodborne illnes in JAPAN

SEAFOOD

wound infections

Question 13

V. vulnificus

Answer 13

OYSTERS in USA

wound infections

SEPSIS, LIVER DYSFUNCTION