Chloramphenicol Flashcards
1
Q
Chloramphenicol MoA
A
Binds to 50S of 70S ribosome
Prevents peptide bond formation
Static activity Except for:
HNS (H. Influenzae, Strep Penumo, Nisseria Meningitidis)
2
Q
Chloramphenicol MoR
A
Reduced permeability or uptake
Ribosomal mutation
Acetyltransferase inactivation
3
Q
Chloramphenicol Absorption
A
Well absorbed by GI Tract
IV administration 70% peak follws oral administration
4
Q
Chloramphenicol Distribution
A
Not highly protein bound
CSF Levels are 30-50% of serum levels
Lipid soluble
5
Q
Chloramphenicol Elimination
A
Metabolized by Liver
6
Q
Chloramphenicol Uses
A
3rd world countries
Rocky Mountain spotted fever
Typhoid fever
7
Q
Chloramphenicol Side Effect
A
Aplastic anemia
Gray Baby Syndrome (neonates)
- Ab distention
- Vomiting
- Flaccidity
- Cyanosis
- circulatory collapse
