Chirality Applications

Question 1

Rule dictating no of chiral centers (no of Chiral Cs) and no of stereoisomers (R and S configs (mirror images))

Answer 1

no stereoisomers = 2^n. n = no. of chiral centers

Question 2

Enantiomers def

Answer 2

Non-superimposable mirror images with opposite congigurations

Question 3

Diastereomers Def

Answer 3

Not mirror images. Same configuration at 1 chiral C and different at another. Different effects on refracting life (angles are different). May not be different

Question 4

Achiral Distinguishing factor

Answer 4

A line of symmetry

Question 5

Applications of chirality

Answer 5

Different receptor interactions depending on which configuration interacts. 1 side may have more binding site exposed then the other. This typically results in only 1 config being therapeutically active (with some exceptions)

Question 6

Case study of therapuetic properties in enantiomers being harmful

Answer 6

Thalidomide. Molecule A relieved morning sickness and molecule B inteacts with fetus