Chest Flashcards
By convention, lateral X-rays are taken in which position?
Left lateral
normal thickness pst wall bronchus intermedius
<3mm
the black hole
left upper lobe bronchus
what runs through the black hole?
bronchus intermedius
how much higher is left hilum point/angle vs right?
1cm
Hilar point/angle
crossing of RUL pulm v and RLL pulm a
inferior hilar window
btw RUL bronchus and bronchus intermedius
retrotracheal/raider triangle obliterated in what testable setting?
aberrant right subclavian artery
pointy parts mechanical valves point in which direction?
toward direction of BF
PM lead through which valve?
TV
bigger: MV vs AV?
MV
azygos lobe fissure-how many layers of pleura?
azygos v displaced laterally
-covered by 4 layers pleura
how many segments R vs L
R-10
L-8
pig/tracheal bronchus
RUL bronchus off trachea
-asyx, air trapping, recurrent inf
cardiac bronchus-where does it come off, syx’s
supernumerary BLIND ENDING bronchus off bronchus intermedius
-asyx, recurr infs
superior mediastinum
thoracic inlet–>sterno-manubrial junction
contents pst mediastinum
es, thoracic duct, desc aorta
MC pulmonary v anatomic variation
v drains right middle lobe
-matters to electrophysiologist in setting of ablation
Proximal interruption of pulmonary artery
- Congenital absence of R > L PA w/ more distal pulmonary vasculature –> hemithorax volume loss
- opposite side of AA
- ass: PDA. Left PA: TOF, Truncus
- recurrent infections (lack of bs)
patterns of atelectasis
- obstructive/absorptive
- compressive/relaxation/passive
- fibrotic/cicatrization
- adhesive
superior triangle sign
RUL (RLL?) atelectasis –> mediastinal vess pulled R –> trianglular opacity R of trachea
right middle lobe syndrome
chronic RML atelectasis via MAI
S Sign of Golden
RUL central obstr
luftsichel sign
LUL central obstr
non visualization aortic knob
LUL atelectasis
peaking of diaphragm
-volume loss –> pulmonary ligament
flat waste sign
flattened hilum & heart border in LLL atelectasis
cervicothoracic sign
obliteration pst junction line (above clavicles) –> pst mediastinal mass
pulmonary vs mediastinal origin angles w/ lung
acute=pulm
obtuse=mediastinal
lobar PNA-types
- SP
- legionella
- klebsiella
- proteus
- morganella
BW: bulging fissure
klebsiella
-exuberant inflamm
Staph Aureus PNA appearance
bronchopulmonary- BL, patchy opacities, abscess
-MRSA-no classic findings
anthrax classic app
- hemorrhagic lymphadenitis, mediastinitis, hemothorax
- med widening
klebsiella vs conventional PNA
+inflamm, PE, empyema, cavity
- EtOH, nursing home
- “current jelly” sputum
H influenza PNA-app, who
bronchitis +/- BL LL bronchopneumonia
-COPD, ø spleen
pseudomonas-app, who
- icu on vent. CF/1˚ ciliary dyskinesia
- patchy opacities, abs, Pl Eff common (small)
areas of ground-glass attenuation - tends to involve multiple lobes and may demonstrate an upper zonal predilection 4
bronchial wall thickening
peribronchial infiltration and areas of consolidation.
legionella-who, appearance
-COPD, crappy air conditioners
-per sublobar opacities surr by GG
+cavitation in immunosuppressed
*xray lag behind resolution of symptoms
xray lag behind resolution of symptoms
legionella
mcc pulmonary cavitation/abscess
aspiration PNA
aspiration PNA-where, img, compl
- R side. Supine: pst lobes. Upright: basal lower lobes
- MCC pulmonary cavitation, abs
- mc compl=empyema –> bronchopleural fistula
mc complication of aspiration PNA
empyema –> bronchopleural fistula
actinomycosis-how, img
- dental procedure –> mandible osteoporosis –> aspiration
- per lower lobes
- aggressive + rib OM, cw invasion
mycoplasma pulmonary findings
reticular + TIB
nocardia PNA
- 50% immcompr, common s/p cardiac transplant. AIDS < 50
- consolidation/mass, nod w/ surr reticulation +/- cav
- PlEff
- +/- inv pleura, cw, mediastinum
- necrotizing in imm compr
pulmonary considerations s/p bone marrow tx
- infection (50%, MCC death)
- Graft vs Host
- PTLD
Pulmonary graft vs host-phases
- Acute (20-100d)- GI, skin, liver.
- Chronic (>100 d)-lymphocytic infiltration of aw & obliterative bronchiolitis
Bmarrow Tx pulmonary findings time divisions
- early neutropenic (0-30d)
- early (30-90d)
- late (>90d)
Early neutropenic s/p bmarrow tx-time frame & pulm findings
- <30 d
- pulm edema, hemorrhage, drug induced lung injury
- fungal PNA (invasive aspergillosis)
Early pulm findings s/p bmarrow tx-time frame & pulm findings
- 30-90 d
- PCP, CMV
Late pulm findings s/p bmarrow tx-time frame & pulm findings
- > 90
- bronchiolitis obliterates, cryptogenic orgz pna
CD4 >200
- bacterial
- Tb
CD4 <200
PCP, atypical mycobacterium
CD4 <100
CMV, disseminated fungal, mycobacterial
PCP classic findings
- central/perihilar UL gg opacities
- +/- thin walled cystic in gg opacities (30%)
AIDS + gg
PCP
aids + opacity
strep pna=MC
- CD4 low-Tb
- chronic-lymphoma or capos
aids + persistent opacities
lymphoma
aids + flame shaped perihilar opacity
kaposi sarcoma
aids + lung cysts
lip (pediatric)
Aids + lung cysts + gg + PTX
PCP
aids + hyper vascular LNs
castleman or kaposi
aids + MF airspace opacities
bacterial or fungal
aids + gg
PCP
-<100 and PCP as answer choice not provided: CMV
4 phases of Tb
- 1˚
- 1˚ disseminated
- latent
- 2˚/post 1˚/reactivation
immune reconstitution inflammatory syndrome
- worsening of syx’s in AIDS + Tb once started on HAART
- rx: steroids
1˚ Tb MOA:
inhalation –> necrosis –> immune mediated attack –> granuloma (ghon focus) –> nodal expansion –> Ca (ranke complex) –> atelectasis (obstr)
- -> rupture: endobronchial (aw) or hematog (bv) spread =1˚ progressive spread
- pleural effusions
- cav uncommon
Tb LAD in kids
-bulky
what determines MOA of TB 1˚ progressive spread?
if node ruptured into aw (endobronchial spread) or bv (hematog spread)
RFs for 1˚ progressive spread in Tb
- HIV (MC)
- other imm suppr: tx, steroids
- jejunoileal bypass, subtotal gastrectomy, silicosis
Latent Tb
- (+) PPD, (-) CXR, ø syx’s
- vaccination
- PPD conversion = 9 mo INH
Tb post primary/reactivation
- progression MC
- UL/sup LL cavitation + nodular opac (endobronchial spread)
- Hematog spread –> miliary pattern
- Rasmussen aneurysm-pulm a’s near cavity
AIDS + Tb
- CD4 >200-reactivation (cavitation)
- CD4 <200- 1˚ progressive (adenopathy, consolidation, biliary)
- NOT lobar
non-TB mycobacterium to know-orgm names
- M avium-intracellulare complex
- M Kansasii
- M absessus
cavity/classic type non-tb myco
old white male smoker. looks like reactivation Tb
non-classic/bronchiectatis type non-tb myco
RML & lingular TIB + cylindrical bronchiectasis
HIV type non-tb myco
CD4 <100
GI –> blood –> mediastinal LAD (MC)
+other pulm findings bc often mixed with other inf
+SMG, HMG
Hypersensitivty type non-tb myco
CL gg opacities
3 types of aspergillus
1) normal immune-aspergilloma
2) suppressed immune- invasive, “air crescent sign”, halo sgx
3) hyperimmune-bronchiectasis + finger in glove
aspergilloma
aspergillum ball in EXISTING cavity
*moves w/ positional change
invasive aspergilloma-who, classic sgx’s
- AIDS, tx
- peripheral wedge shaped infarcts +
- air crescent sign-healing 2-3 wk s/p rx
- halo sign
Allergic broncho pulmonary aspergillosis-ing features and dx criteria
UL, central bronchiectasis saccular bronchiectasis + finger in glove
-diagnosis requires:
1) serum IgE (+) OR (+) Asp hypersensitivity skin test
+
2) total IgE >1000,
mucormycosis
- invasive fungus
- impaired immunity (DM, steroids, aids)
- face + lungs + medisatinal, pleural, cw invasion
CMV PNA who
- reactivation s/p bmarr tx
- infusion of CMV positive marrow/other blood products
cmv PNA img
mult nodules, gg or consolidation
measles pna
Mult gg opacities + smaller nodules
- bf or after skin
- compl + in pregnant or immunocompromised
influenza PNA
coalescent LL opacities, Pl Eff rare
-ie: think covid 19 vibe
varicella-appearance
mult peripheral nodular opacities
-Ca when healed
varicella peds vs adults
- peds: chickenpox
- adults (immcompr)=pna
EBV ass
-ass w/ PTLD (pst transplant lymphoproliferative disorders) and ARL
EBV pna
LAD + SMG. lungs uncommonly affected.
MC radiographic abN of EBV
SMG
COVID-19 acute vs chronic
- Acute (<14 d): BL per GGO, bronchovascular thickening. Crazy paving & reverse halo
- chronic (>14d): fibrous stripes
CAVITY
Cancer (SCC) AutoImmune (granulomatosis w/ polyangiits, RA, Caplan) Vascular (SE, bland emb) Inf (Tb, SA, aspiration) Trauma-pneumatoceles Young (CCAM, sequestration)
Lung cancer RFs
- age (v rare <40yo)
- smoking (90% of lung cancer cases)
- copd (even if you didn’t smoke)
- exposure-arsenic, nicke, uranium, asbestos, chromium, beryllium, radon
- family hx
- fibrosis-10x the risk
who gets screened for lung cancer?
-55-80 yo + 30 pack yr hx (currently or quit in last 15 yrs
CT dose recommendation for lung cancer screening
CTDI vol < 3mGy
what’s considered “growth” for lung nodule?
1.5 mm in 1 yr
What scoring system is used in lung cancer screening?
LUNG RADS
how do you score findings in lung cancer screening?
One nodule (most suspicious)
Can you be enrolled in lung cancer screening with a history of lung cancer?
Treated, remote (>5 yrs) and must fall into normal inclusion criteria (55-80 yo + 30 pack yr)
Fleischer Society Overview
- incidental SOLID nodule
- > 35 yo w/o known or suspected malignancy, imm compromise
- risk stratification (mild, intermediate, high)-RFs & nodule characteristics
- f/u based on arbitrary guess of cancer risk >1%
- thin slice CT (<1.5mm)
how to measure nodule for FS?
avg diam (short + long/2)
Fleichner Society RFs to consider
smoking, cancer hx, family hx, age, exposures
what to do with perifissural nodules re: FS
nothing
how are nodules stratified re: FS
number & risk
-risk= nodule char + pt RFs
likely of malignancy re: nodule density
- mixed > gg > solid
- solitary > mult
SPN benign morph Ca
1) solid/diffuse
2) laminated
3) central
4) popcorn
SPN malignant morph Ca
- eccentric
- popcorn + GI
- solid + osteosarcoma
What makes you think benign SPN?
- fat
- rapid doubling (<1 mo)
- slow doubling (>16 mo, 2 yrs=B9)
what makes you think cancer in setting of SPN?
- spiculated (“corona radiata sgx”)
- air bronchogram (5x MC in malignant SPN, 50% adenoCa)
- mixed density
when do you use PET for SPN? What SUV is considered HOT? when do you think cancer vs B9?
- > 1 cm
- SUV > 2.5
- solid: hot=CA, cold-not
- gg: hot=inf, cold=CA
Lung CA MC loc?
- UL (70%)-exc LL fibr
- R (1.5x)
SPN in setting hot h/n CA?
-1˚ > met (sim RFs)
nodule decreasing in size: mal or b9?
either! (mal if increasing density)
Paraneoplastic syndromes of lung cancer
- nonSC: parathyroid
- SC: SIADH, ACTH, Lambert eaton (often bf dx)
Lambert eaton
proximal weakness from abN release acetylcholine at NMJ
TTF-1 (thyroid transcription factor 1) and lung CA
-not expressed in non-small cell squamous
MC lung CA subtype to present as SPN
Adeno
MC and least common lung CA subtypes
- MC= AdenoCa (35%)
- LC= non-SC large (15%)
Lung AdenoCA loc and known ass
- Upper lobe, per
- pulm fibrosis
LA is on the Coast
Large & Adeno favor peripheral locs
lung CA loc based on syx
central=hemoptysis
-per=pleuritic cp
MC 1˚ lung CA to cause SVC obstr & PNS?
small cell
Small cell lung CA img
central LAD
spectrum of adenocarcinoma
- pre-invasive
- AAH: atypical adenomatous HP of lung
- ACIS (Adeno In Situ)
- minimally invasive adenoCA (MIA)
- Invasive mucinous adenoCA
Atypical adenomatous HP of lung (AAH) vs Adeno In Situ (ACIS) vs minimally invasive (MIA)
- AAH: <5mm, mild, gg
- ACIS: <3cm, mixed
- MIA: <3 + stromal invasion (<5mm) (>5mm=lepidic)
superior sulcus/pancoast tumor-cause, pres, img modality used to stage, ci to sx
- non-SC
- shoulder pain
- staging: MRI (brachial plexus)
- CI to surgery:
- 50% VB
- spinal canal
- upper brachial plexus (C8+)
- diaph paralysis (C3-5)
- distal mets
measuring a nodule for lung CA staging
- solid=max diam
- mixed- solid part
staging multiple lesions in lung CA
- synchronus-others=mets, changes stage
- metachronous- stage individually
important nodal stage for lobectomy/resection
Stage 3B=N3 or T4, surgically unresectable
level 1 vs 2 nodes in lung CA
- border: lower level of clavicles/upper border of manubrium
- level 1= above, N3
- level 2= below, N2
who gets wedge resection in lung Ca
stage 1A/B, per & <2cm
wedge resection vs lobectomy
wedge = better pulm reserve
bronchopleural fistula s/p pneumonectomy
-post op space progressively filling w/ air rather than fluid
compensatory emphysema (post pneumonectomy syndrome)
-hyperexpansion of lung to compensate fo absence of other
pulmonary radiation changes
- immediate-bubbles
- early (1-3mo)-homogenous patchy ggo.
- late-dense consol, traction bronchiectasis, volume loss
- linear
- rib fx
lung CA recurrence
High (2yrs)
- loc: per of radiation bed, regional LNs, bronchial stump
- app: enhancing, enlarging round lesion along resection line/bronchial stump. New LNs (>1cm), new persistent PlEff
mc benign lung mass
hamartoma
pulmonary hamartoma classic app
- fat (60%) & popcorn Ca
- hot on PET
- uncommonly endobronchial
MC lung tumor in AIDs
- Kaposi sarcoma (requires CD4 <200)- MC
- lymphoma-2nd MC
MC liver neoplasm in AIDS
Kaposi sarcoma
kaposi sarcoma pulmonary img, consistency of pl eff
- slow growing flame shaped opacities in asyx pts
- bloody Pl Eff (50%)
- thall+, gall (-)
MC pulm mets via dir invasion
- es
- lymphoma
- malignant GC
GEL
order of commonness: pulm met, pleural met, mesothelioma pulm met
-in that order
mc img hematogenous mets to lungs
-mult round, smooth-bordered, randomly distr LL nodules
cannonball mets-which cancers?
RCC, chorioCA (testicle)
lymphangitic carcinomatosis causes
- bronchogenic CA=MC
- breast, stomach, pancreas, prostate (paint brush paint brush serosa)
lymphangitic carcinomatosis vs fibrosis
LC does not distort lobule
pulmonary lymphoma 4 flavors
- 1˚
- 2˚,
- AIDS
- PTLD
1˚ pulmonary lymphoma-time frame to qualify, type
- > 3 mo’s w/o extrathoracic involvement
- rare, NHL (MALToma)
2˚ pulmonary lymphoma-HL vs NHL lung parenchyma involvement and percent cases Intrathoracic at time of presentation
- pulm inv of systemic lymphoma
- NHL>HL
- HL = LN + parenchyma (40%), 85% Intrathoracic at pres
- NHL-parenchyma (25%), 45% Intrathoracic at pres
pulm PTLD-what, when, img
-bcell lymphoma ass w/ EB virus s/p solid or stem cell tx
-~1 yr (later=more aggressive)
-well-defined nods/mass, patchy as consol, halo, interlobular thick
+/- nodal dx
AIDS related pulmonary lymphoma (ARPL)-ass, CD4 county, img, other findings
- high grade NHL, EBV ass
- CD4<100
- MC img: mult per nods (1-5cm), PlEff, LAD
- extranodal common: CNS, bmarr, lung, liver, bowel
thallium vs gallium in kaposi vs lymphoma vs toxo
- Kaposi: Thall+, Gall (-)
- lymphoma: Thall + , Gall +, PET+
- toxo: thall -, gall +
Poland syndrome
UL abscent pectoral major & minor +/- weird limbs
bronchial atresia
- in utero vascular insult –> SHORT SEGM lobar, segm, subsegmental bronchus
- LUL apical pst segm
- MC= hyperinflated lobe (via collateral flow through pores of Kohn and canals of Lambert)
- decreased pulm vasc
- hilar nodule (branching, finger in glove)
- asyx, recurr pna