Chemotherapy VI Principles of Cancer Therapy

Question 1

What is the most important factor for the prognosis and treatment of cancer?

Answer 1

Stage of the cancer

Question 2

What is one of the most successful methods for curing cancer?

Answer 2

Surgery - localized disease finds the highest success with good surgical removal

Question 3

What chemotherapy agent is contraindicated in those with renal failure?

Answer 3

Cisplatin

Question 4

What chemotherapy agent is contraindicated in those with CHF?

Answer 4

Doxorubicin

Question 5

What is adjuvant chemotherapy?

Answer 5

Therapy for patients who have had cancer removed but are at risk of recurrence

Question 6

Neoadjuvant Chemotherapy

Answer 6

Reduces tumor cells prior to surgery

Question 7

Log Kill Hypothesis

Answer 7

The killing of cancer cells by the chemotherapy drugs follows first order kinetics. The same fraction of cancer cells is killed with each administration of chemotherapy.

Question 8

Why is combination chemotherapy better?

Answer 8

Combinations provide maximal cell kill within the range of toxicity tolerated by the host for each drug - log cell kill is increased