Androgens Flashcards
What is the most potent androgen?
DHT
What are some actions of androgens?
- Promotes spermatogenesis
- Promotes lean body mass and skeletal muscle growth
- Reduces fat mass
- Growth of larynx
- Closure of the epiphyseal plates
- Puberty in females
- Erythropoiesis
What is the effect of androgens on clotting factor?
Decreases synthesis of clotting factors
What is the effect of estrogens on clotting factor?
Increases synthesis
What are the consequences of decreased androgens in males?
- Decreased libido
- Decreased muscle mass
- Decreased axillary and pubic hair
- Anemia and osteoporosis
What are the indications of androgens?
- HRT in hypogonadism
- Induction of puberty
- Osteoporosis in males
What are some contraindications of androgens as HRT?
- Breast cancer in men
- Prostate cancer
- Pregnancy
Flutamide MOA
Competitive antagonist of DHT and testosterone binding
Flutamide Indications
- Metastatic prostate cancer
- BPH
Flutamide SE
- Hepatotoxicity
- Diarrhea/Nausea
- Hematopoietic Diseases
Flutamide Contraindication
Severe hepatic impairment
Leuprolide MOA
GnRH agonist
Spironolactone MOA
Inhibition of DHT and T binding
*Also is an aldosterone receptor antagonist
Spironolactone Indications
- Hirsutism
- HTN
- Acne
- Edema from CHF
- Hypokalemia
Spironolactone Contraindications
- Anuria
- Hyperkalemia
- Renal insufficiency