chemotherapy

Question 1

what drugs are used for induction in AML?

Answer 1

(TAD)

ARA-C, daunorubicin, and thioguanine

Question 2

what is the post-remission therapy for AML?

Answer 2

ARA-C

autologous SCT

Question 3

what is the induction therapy for childhood APL?

Answer 3

ATRA and an anthracycline with or without ARA-C

Question 4

what is used in remission/consolidation therapy for APL?

Answer 4

ATRA +ARA-C+daunorubicin or

ATRA+idarubicin

Question 5

what is the maintenance therapy for APL?

Answer 5

ATRA+6MP+MTX

Question 6

what is the BBW for AsO3?

Answer 6

CV issues: AV block, QT prolongation

Question 7

what is are the two induction therapies for ALL?

Answer 7

corticosteroid+vincristine+anthracycline

-imatinib if BCR-ABL facor

Question 8

what about therapy for ALL is unique?

Answer 8

CNS prophylaxis: intrathecal MTX

Question 9

what is consolidation therapy for ALL?

Answer 9

MTX and 6MP

Question 10

what drugs are used for CML if acute phase?

Answer 10

busulfan, hydroxyurea, ARA-C, IFN-alpha

Question 11

what are toxicities of imatinib?

Answer 11

GI toxicities, elevation in hepatic enzymes, cytopenias

Question 12

what is the treatment for CLL?

Answer 12

fludarabine+cyclophosphamide or
fludarabine+rituximab or
fludarabine+cyclophosphamide+rituximab

Question 13

what is bendamustine?

Answer 13

antimetabolite and alkylating agent
may be used in CLL
less susceptible to resistance than other alyklators

Question 14

what three drugs are approved for hairy cell?

Answer 14

cladribine, IFN-alpha, and pentostatin

-caldribine and pentostatin=purine analogs

Question 15

what is the combination therapy for Hodgkin’s?

Answer 15

anthracycline+mitotic spindle inhibitor+alkylating agent+corticosteroid

Question 16

what is the combination therapy for low-stage non-Hodgkin’s lymphoma?

Answer 16

COMP: cyclophosphamide+vincristine+MTX+prednisone

Question 17

what is the combination therapy for high stage non-Hodgkin’s lymphoma?

Answer 17

R-CHOP: rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone

Question 18

what is tositumomab?

Answer 18

radioactively labeled anti-CD20 antibody

Question 19

what is ibritumomab?

Answer 19

radioactively labeled anti-CD20 antibody

Question 20

what two combinations are used for Burkitt’s? what is special about how they are given?

Answer 20

cyclophosphamide+MTX
vincristine+doxorubicin
-give IT for CNS coverage

Question 21

what is the toxicity of pegaspargase?

Answer 21

hypersensitivity and pancreatitis

Question 22

what are the toxicities of bendamustine?

Answer 22

elevated liver enzymes, hyperuricemia

Question 23

what’s the toxicity of cladribine?

Answer 23

neurotoxicity

Question 24

what is the toxicity of cyclophosphamide?

Answer 24

renal malfunciton, hemorrhagic cystitis

Question 25

what are the toxicities of dacarbazine?

Answer 25

hepatic disease, teratogenic

Question 26

what can fludarabine cause? what don’t you give it with?

Answer 26

coma/seizures

pentostatin

Question 27

what’s the issue with hydroxyurea?

Answer 27

teratogenic

Question 28

what are the problems with IFN-alpha?

Answer 28

cardiac disease, depression, don’t give with autoimmune diseases

Question 29

what can dasatinib cause?

Answer 29

fluid retention

Question 30

what is the problem with imatinib?

Answer 30

birth defects

Question 31

what is the problem with nilotinib?

Answer 31

QT prolongation, contraindicated with hypokalemia

Question 32

what are the side effects of rituximab?

Answer 32

dermatitis, leukoencephalopathy