chemotherapy Flashcards
what drugs are used for induction in AML?
(TAD)
ARA-C, daunorubicin, and thioguanine
what is the post-remission therapy for AML?
ARA-C
autologous SCT
what is the induction therapy for childhood APL?
ATRA and an anthracycline with or without ARA-C
what is used in remission/consolidation therapy for APL?
ATRA +ARA-C+daunorubicin or
ATRA+idarubicin
what is the maintenance therapy for APL?
ATRA+6MP+MTX
what is the BBW for AsO3?
CV issues: AV block, QT prolongation
what is are the two induction therapies for ALL?
corticosteroid+vincristine+anthracycline
-imatinib if BCR-ABL facor
what about therapy for ALL is unique?
CNS prophylaxis: intrathecal MTX
what is consolidation therapy for ALL?
MTX and 6MP
what drugs are used for CML if acute phase?
busulfan, hydroxyurea, ARA-C, IFN-alpha
what are toxicities of imatinib?
GI toxicities, elevation in hepatic enzymes, cytopenias
what is the treatment for CLL?
fludarabine+cyclophosphamide or
fludarabine+rituximab or
fludarabine+cyclophosphamide+rituximab
what is bendamustine?
antimetabolite and alkylating agent
may be used in CLL
less susceptible to resistance than other alyklators
what three drugs are approved for hairy cell?
cladribine, IFN-alpha, and pentostatin
-caldribine and pentostatin=purine analogs
what is the combination therapy for Hodgkin’s?
anthracycline+mitotic spindle inhibitor+alkylating agent+corticosteroid
what is the combination therapy for low-stage non-Hodgkin’s lymphoma?
COMP: cyclophosphamide+vincristine+MTX+prednisone
what is the combination therapy for high stage non-Hodgkin’s lymphoma?
R-CHOP: rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone
what is tositumomab?
radioactively labeled anti-CD20 antibody
what is ibritumomab?
radioactively labeled anti-CD20 antibody
what two combinations are used for Burkitt’s? what is special about how they are given?
cyclophosphamide+MTX
vincristine+doxorubicin
-give IT for CNS coverage
what is the toxicity of pegaspargase?
hypersensitivity and pancreatitis
what are the toxicities of bendamustine?
elevated liver enzymes, hyperuricemia
what’s the toxicity of cladribine?
neurotoxicity
what is the toxicity of cyclophosphamide?
renal malfunciton, hemorrhagic cystitis
what are the toxicities of dacarbazine?
hepatic disease, teratogenic
what can fludarabine cause? what don’t you give it with?
coma/seizures
pentostatin
what’s the issue with hydroxyurea?
teratogenic
what are the problems with IFN-alpha?
cardiac disease, depression, don’t give with autoimmune diseases
what can dasatinib cause?
fluid retention
what is the problem with imatinib?
birth defects
what is the problem with nilotinib?
QT prolongation, contraindicated with hypokalemia
what are the side effects of rituximab?
dermatitis, leukoencephalopathy
