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Pharm 233 Final > Chemotherapy > Flashcards

Chemotherapy Flashcards

1
Q

Cyclophosphamide

A

Nitrogen mustard

Alkylating agent

Treatment of breast cancer and lymphoma

Impaired wound healing
Bone marrow toxicity
Alopecia
Depression of growth in children
Sterility
Teratogenicity
Carcinogenicity

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2
Q

Procabazine

A

Triazine/Tetrazine

Alkylating agent

Treatment of lymphoma

Impaired wound healing
Bone marrow toxicity
Alopecia
Depression of growth in children
Sterility
Teratogenicity
Carcinogenicity

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3
Q

Cisplatin

A

Platinum

Alkylating agent

Treatment of lung cancer

Impaired wound healing
Bone marrow toxicity
Alopecia
Depression of growth in children
Sterility
Teratogenicity
Carcinogenicity

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4
Q

Carboplatin

A

Platinum

Alkylating agent

Treatment of lung cancer

Impaired wound healing
Bone marrow toxicity
Alopecia
Depression of growth in children
Sterility
Teratogenicity
Carcinogenicity

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5
Q

Oxaliplatin

A

Platinum

Alkylating agent

Treatment of colon cancer

Impaired wound healing
Bone marrow toxicity
Alopecia
Depression of growth in children
Sterility
Teratogenicity
Carcinogenicity

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6
Q

Methotrexate

A

Antimetabolite

Prevents the synthesis of purine nucleotides and thymidylate

Treatment of leukemia

Bone marrow toxicity
Damage to the epithelium of the GI tract

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7
Q

Fluorouracil

A

Antimetabolite

Increases levels of dUMP and causes DNA damage

Treatment of colon and breast cancers

Bone marrow toxicity
Damage to the epithelium of the GI tract

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8
Q

Cytarabine

A

Antimetabolite

Inhibition of DNA polymerase

Treatment of leukemia

Bone marrow toxicity
Damage to the epithelium of the GI tract

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9
Q

Mercaptopurine

A

Antimetabolite

Blocks or subverts DNA synthesis

Treatment of leukemia

Bone marrow toxicity
Damage to the epithelium of the GI tract

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10
Q

Capecitabine

A

Antimetabolite

Blocks or subverts DNA synthesis

Treatment of colon and breast cancers

Bone marrow toxicity
Damage to the epithelium of the GI tract

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11
Q

Gemcitabine

A

Antimetabolite

Blocks or subverts DNA synthesis

Treatment of lung cancer

Bone marrow toxicity
Damage to the epithelium of the GI tract

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12
Q

Pemetrexed

A

Antimetabolite

Blocks or subverts DNA synthesis

Treatment of lung cancer

Bone marrow toxicity
Damage to the epithelium of the GI tract

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13
Q

Doxorubicin

A

Anthracycline - topoisomerase inhibitor

Induces tumor suppressor protein p53

Treatment of breast cancer and lymphoma

Cardiotoxicity
Alopecia

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14
Q

Idarubicin

A

Anthracycline - topoisomerase inhibitor

Induces tumor suppressor protein p53

Treatment of leukemia

Cardiotoxicity
Alopecia

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15
Q

Epirubicin

A

Anthracycline - topoisomerase inhibitor

Induces tumor suppressor protein p53

Treatment of breast cancer

Cardiotoxicity
Alopecia

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16
Q

Etoposide

A

Plant-based compound

Epipodophyllotoxin - topoisomerase inhibitor

Induces tumor suppressor protein p53

Treatment of lung cancer and lymphoma

Bone marrow suppression
Cardiotoxicity
Alopecia

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17
Q

Irinotecan

A

Camptothecin derivative - topoisomerase inhibitor

Induces tumor suppressor protein p53

Treatment of colon cancer

Cardiotoxicity
Alopecia

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18
Q

Paclitaxel

A

Plant-based compound

Acts on microtubules, freezing them in a polymerized state resulting in cell cycle arrest and apoptosis

Bone marrow suppression
Neurotoxicity

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19
Q

Prednisolone

A

Glucocorticoid

Inhibits lymphocyte proliferation

Treatment of leukemias and lymphomas

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20
Q

Tamoxifen

A

Antiestrogen

Treatment of hormone-dependent breast cancer

Blocks estrogen-responsive genes

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21
Q

Flutamide

A

Antiandrogen

Treatment of prostate tumors

22
Q

Cyproterone

A

Antiandrogen

Treatment of prostate tumors

23
Q

Bicalutamide

A

Antiandrogen

Treatment of prostate tumors

24
Q

Anastrozole

A

Aromatase inhibitor

Suppress synthesis of estrogen from androgens

Treatment of breast cancer in postmenopausal women

25
Q

Letrozole

A

Aromatase inhibitor

Suppress synthesis of estrogen from androgens

Treatment of breast cancer in postmenopausal women

26
Q

Exemestane

A

Aromatase inhibitor

Suppress synthesis of estrogen from androgens

Treatment of breast cancer in postmenopausal women

27
Q

Vincristine

A

Vinca alkaloid

Antimicrotubule

Used in combination with hormone treatments

Treatment of lymphoma and breast cancer

28
Q

Vinblastine

A

Vinca alkaloid

Antimicrotubule

Used in combination with hormone treatments

Treatment of lymphoma

29
Q

Vinorelbine

A

Vinca alkaloid

Antimicrotubule

Used in combination with hormone treatments

Treatment of breast and lung cancer

30
Q

Paclitaxel

A

Taxane

Antimicrotubule

Used in combination with hormone treatments

Treatment of breast and lung cancer

31
Q

Docetaxel

A

Taxane

Antimicrotubule

Used in combination with hormone treatments

Treatment of breast and prostate cancer

32
Q

Nab-paclitaxel

A

Taxane

Antimicrotubule

Used in combination with hormone treatments

Treatment of breast cancer

33
Q

Rituximab

A

mAB

Binds to CD20

Treatment of lymphoma, including Hodgkins

Hypotension
Chills and fevers

34
Q

Trastuzumab

A

Aka Herceptin

mAB

Inhibits oncogenic receptor HER2

Treatment of HER2+ breast cancer

Hypotension
Chills and fevers
Cardiotoxicity (suppression, not loss, therefore reversible)

35
Q

Bevacizumab

A

mAB

Neutralizes VEGF (angiogenesis)

Treatment of colorectal cancer

Hypotension
Chills and fevers

36
Q

Catumaxomab

A

mAB

Binds EpCAM, which is overexpressed in some malignant cells and activates immune cells to clear cancer cells

Hypotension
Chills and fevers

37
Q

Imatinib

A

Protein kinase inhibitor

Great for treatment of leukemia

Binds a cancer-specific protein, but also other targets and inhibits other body/cell functions

38
Q

Erlotinib

A

Protein kinase inhibitor

Targets EGFR

Treatment of non-small cell lung and pancreatic cancer

GI symptoms
Fatigue
Headaches
Cardiotoxicity

39
Q

Sorafenib

A

Protein kinase inhibitor

Targets several tyrosine-kinase receptors

40
Q

Gefitinib

A

Protein kinase inhibitor

Targets EGFR

Treatment of lung cancer

GI symptoms
Fatigue
Headaches
Cardiotoxicity

41
Q

Afatinib

A

Protein kinase inhibitor

Targets EGFR

Treatment of lung cancer

GI symptoms
Fatigue
Headaches
Cardiotoxicity

42
Q

Osimertinib

A

Protein kinase inhibitor

Targets EGFR

Treatment of lung cancer

GI symptoms
Fatigue
Headaches
Cardiotoxicity

43
Q

Cetuximab

A

mAB

Targets EGFR

Treatment of colon cancer

GI symptoms
Fatigue
Headaches
Cardiotoxicity

44
Q

Panitumumab

A

mAB

Targets EGFR

Treatment of colon cancer

GI symptoms
Fatigue
Headaches
Cardiotoxicity

45
Q

Hydroxyurea

A

Treatment of leukemia

46
Q

Bleomycin

A

Treatment of lymphoma

47
Q

Asparaginase

A

Treatment of leukemia

48
Q

Nivolumab

A

PD-1/PD-L1 inhibitor

mAB

Treatment of lung cancer

49
Q

Pembrolizumab

A

PD-1/PD-L1 inhibitor

mAB

Treatment of lung cancer

50
Q

Atezolizumab

A

PD-1/PD-L1 inhibitor

mAB

Treatment of lung cancer

51
Q

Durvalumab

A

PD-1/PD-L1 inhibitor

mAB

Treatment of several cancers

52
Q

Ipilimumab

A

CTLA4 inhibitor

mAB

Treatment of several cancers

Pharm 233 Final (11 decks)

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