Chemotherapy Flashcards
What chemo protocol is used mainly for canine lymphoma? What about feline lymphoma?
Canine -discontinuous CHOP/CEOP
Feline - high dose COP
Which is more effective for lymphoma - discontinuous CHOP or CEOP?
CEOP
What are the drugs in discontinuous CHOP?
C - Cyclophosphamide
H - Epirubicin/doxorubicin
O - Vincristine
P - Prednisolone
What are the drugs in discontinuous CEOP?
C - cyclophosphamie
E - etoposide
O - vincristine
P - prednisolone
What chemo protocol is used for feline lymphoma?
High dose COP
Cyclophosphamide
Vincristine
Prednisolone
Which chemotherapy drugs have cumulative cardiotoxicity?
Doxorubicin
Epirubicin
(H in CHOP)
Which chemo drug is hepatotoxic?
Lomustine
Which chemo drugs are nephrotoxic?
Cisplatin
Lomustine (dogs)
Doxorubicin (cats)
What type of cystitis do chemo drugs cause?
Sterile haemorrhagic cystitis
Which drug causes fatal non-cardiogenic pulmonary oedema in cats?
Cisplatin
Which chemo drug causes sterile haemorrhagic cystitis? How can this be prevented?
Cyclophosphamide
Give furosemide to encourage urination
What is the difference between drug density and intensity?
Density = frequency of administration Intensity = dose compared to maxium tolerated dose (MTD)
Which tumour can be treated/prevented with immunotherapy?
Canine melanoma vaccine
What is metronomic chemo?
Continous low dose chemo
cyclophosphamide, NSAID +/- thalidomide
What do the following terms mean in terms of chemo? Primary Adjuvant Neoadjuvant Concurrent
Primary = sole therapy Adjuvant = after surgery Neoadjuvant = before surgery Concurrent = given with radiotherapy
