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Perio Final > Chemotherapeutics > Flashcards

Chemotherapeutics Flashcards

1
Q

Tetracyclines:

  • how does it affect bacteria?
  • What type of bacteria affected?
A
  • Bacteriostatic “slows growth”

- broad spectrum

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2
Q

Tetracyclines:

-Unique affect on the bacteria?

A

-anticollagenase activity

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3
Q

What is the only FDA approved host modulatory therapy?

A

Low-dose doxycycline, it inhibits host response but doesn’t induce bacterial resistance

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4
Q

What 3 diseases do you give systemic antibiotics always?

A
  • LAP
  • GAP
  • Refractory Periodontitis
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5
Q

Tetracyclines:

dosing (3)

A

Tetracycline- 250mg QID for 2-3 wks
Minocycline- 100mg BID for 1 wk
Doxycycline- 100mg BID for 2-3 wks

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6
Q

Tetracyclines:

Which dosage is less affected by calcium?

A

Doxycline

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7
Q

Metronidazole:

  • Mode of action on the bacteria?
  • Which Bacteria?
A
  • Bacterialcidal

- Anaerobes targeted at DNA synthesis

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8
Q

Metronidazole:

  • What diseases used for?(3)
  • Is it used alone?
A

1 ANUG,
2 Aggressive Perio,
3 Refractory Perio (amoxicillin specifically)

-Used in conjunction with a secondary antibiotic

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9
Q

Metronidazole:

Dosage?

A

250mg TID 1wk

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10
Q

Metronidazole:

Side Effects?

A
  • Antabuse (vomiting induced by alcohol consumption)
  • inhibits warfarin
  • avoid lithium
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11
Q

Ciprofloxacin:

  • Used for what bacteria?
  • Commonly used in conjunction?
A
  • Gram Positives and enteric bacteria

- with metronidazole

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12
Q

Penicillins:

  • Mode of Action on bacteria?
  • Affects with bacteria?
A
  • Bactericidal

- Gm+ bacteria

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13
Q

Penicillins:

Dosages 2

A

Amoxicillin (500mg TID for 2 wks)

Augmentin- ???

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14
Q

What is unique about Augmentin?

A

It has clavulanate potassium inhibits penicillinase

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15
Q

Clindamycin:

  • Affective against what bacteria?
  • Big side effect it shares with Penicillins
  • Dosages
A
  • Anaerobes
  • Pseudomembranous Colitis
  • 150mg QID for 1 wk
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16
Q

What can tetracyclines be mixed with?

A

NOT BACTERIOCIDIAL antibiotics…so don’t mix with any others mentioned

17
Q

Birth Control and Pregnancy concerns with antibiotics?

A
  • BC can be lowered with tetracycline

- Tetracycline staining during pregnancy

18
Q

What do NSAIDS inhibit?

A

PGE2-which is a modulator of perio-inflammation

19
Q

What is flurbiprofen?

A

it is a NSAID that is easier on the GI Tract than other NSAIDS (*because it is a topical drug xD )

20
Q

Advantages of Local antimicrobials (3)

A
  • decreased drug dosages
  • increased drug concentrations
  • lowered side effects
21
Q

Disadvantages of local antibicrobials?

A

Doesn’t penetrate into the Connective Tissue, only affects the pocket.

Perio Final (7 decks)

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