Chemokines/adhesion molecules

Question 1

a4B7 interacts with

Answer 1

MADCAM1

Mucosal homing

Question 2

CXCR3 (ligand)

Answer 2

CXCL10

Question 3

DX5

Answer 3

a2 integrin
AKA CD49b
it is the a2 subunit of the VLA-2 receptor

Question 4

What is the ligand for CCR7?

Answer 4

Secondary lymphoid-tissue Chemokine (SLC)/CCL21

Regulates entry of T lymphocytes into lymph node

Question 5

What does CCR7 do

Answer 5

it mediates the basal homing of T lymphocytes into the lymph nodes

Question 6

What is BCA-1

Answer 6

Chemokine that mediates the localization of b cells and specialized T cell subsets into the folicular areas of the lymph nodes.

Question 7

what is the ligand for CCR2?

Answer 7

KC/CCL1 ie MIP2

Question 8

CXCR6

Answer 8

Chemokine expressed on NKT cells. Important for homing to liver sinusoids and survival there (but not other places). Ligand is CXCL16

Question 9

CD62L

Answer 9

L selectin

Mediates entry of naive T cells to LN

Question 10

What does CCR9 do?

Answer 10

Essential for gut homing - but not completely necessary