CHEMO THERAPY (chemical) Flashcards
Dacarbazine
phase nonspecific cell cycle for melanoma, sarcoma, lymphoma. SE: N/V/A
Vinblastine
“vinca alkaloid” (nat occurring chemo agents) from periwinkle plant. Cell cycle phase specific. For lymphoma, BC, bladder, melanoma and testicular CA. SE: alopecia, constipation, leukopenia
Sorafenib (Nexavar)
kinase inhibitor. For unresectable hepatocellular/ renal cell. SE: abd pain, N/V/C/D, dysgeusia (alt taste), dyspepsia, dysphagia, wt loss, GERD, anemia, anorexia, bleeding, fatigue, low albumin/ Ca/ K/ Na/ thyroid, neutropenia, xerosis (dry skin)
Nilotinib
Tyrosine kinase inhibitor for CML (adult and peds). SE: abd pain, anorexia, N/V/D/C, dysgeusia, dyspepsia, pancreatitis, weakness, DM, eosinophillia, epistaxis, fever, inc Ca/ bili/ lipids/ phos/ K, wt loss, low Mg
Gemzar
Antimetabolite for soft and solid tumors. SE: myelosuppression, alopecia, anorexia, N/V, low BG/ Mg
Placlitaxel (Abraxane)
Microtubule inhibitor for BC, lung, pancreatic. SE: anorexia, N/V/D/C, fatigue neutropenia, anemia, dehydration, inc LFT’s, HTN
Xeloda (Capecitabine)
Antimetabolite. Selectively delivers Flourouracil selectively for BC, colon. SE: abd pain, anorexia, N/V/D/C, low albumin, stomatitis, anemia, inc LFT’s, neutropenia
Methotrexate
Folate antimetabolite for many cancers. May be used in other things such as GVHD, RA, psoriasis. During toxicity will require folate (calcium leucovorin). SE: N/V/D, stomatitis, inc LFT’s, immunosuppression, photosensitivity
*folate, B12, lactose and fat are less absorbed and mouth sores are common
Capecitabine
Generates Flourouracil in tumor cells. For BC, colorectal. SE: abd pain, anorexia, N/V/D/C, fatigue, edema, stomatitis, weakness, anemia, Inc LFT’s, fever, low albumin
Oxaliplatin
IV w/ flourouracil for Colon CA. Inhibits DNA replication. (Alkylating agent)
SE: neuropathy sensitive to cold, abd pain, anemia, anorexia, N/V/D/C, dysgeusia, dyspepsia, edema, Inc LFT’s, fatigue, inc BG, wt loss, neutropenia
