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CSO Study Cards > Chemo interactions from Appendix 8 > Flashcards

Chemo interactions from Appendix 8 Flashcards

1
Q

Zometa drug/nutrient interaction

A

Take oral supplement of

500mg calcium
400 IU vitamin D

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2
Q

Vincristine/Oncovin drug/nutrient interaction

A

Stool softeners/laxative can help prevent constipation

Avoid St John’s Wort/grapefruit

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3
Q

*F5U/Fluororacil drug/nutrient interaction and side effects

A

For IV bolus: ice chips 15min pre/post infusion to reduce mucositis

Vitamin B6 (50-100mg 2-3x/day) may reduce hand foot syndrome

side effects: mucositis, diarrhea, possible thiamine deficiency, possible cardiac failure

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4
Q

Mercaptopurine drug/nutrient interaction

A

Avoid dairy around timing of drug

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5
Q

Methotrexate drug/nutrient interaction

A

Avoid folic acid and derivatives during therapy

Avoid alcohol

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6
Q

Nilotinib/tasigna drug/nutrient interaction

A

May cause diarrhea due to lactose content

Use lactase if so

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7
Q

Oxaliplatin/eloxatin drug/nutrient interaction

A

Avoid cold exposure/ food or beverages for up to 5 days after IV
May increase with subsequent cycles

B6 may reduce hand/foot syndrome (50mg 2-3x/d)

monitor Ca and Mg

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8
Q

Melphalan drug/nutrient interaction

A

Take anti-emetic one hour before oral dose

Small frequent meals

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9
Q

Panitumumab drug/nutrient interaction

A

Monitor serum Mg

Especially in elderly, and baseline low Mg

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10
Q

Permetrexed/vectobix drug/nutrient interaction

A

To prevent anemia:

  • folic acid po 1 week before, during and post treatment
  • vitamin b12 IM injections given every 3 c)ycles starting 1 week prior
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11
Q

Procarbazine drug/nutrient interaction

A

Avoid high tyramine foods
Beer, red wine, sherry, brewers yeast
Favs beans, raspberries, figs, dried fruit, avocado, bananas
Miso soup, soy sauce, sauerkraut, aged cheeses, anchovies, caviar, livers /meat extracts
Salami, sausage, bologna, pepperoni
Avoid caffeine
Avoid alcohol
Can cause hypertensive crisis or intracranial hemorrhage

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12
Q

Stivarga/regorafenib drug/nutrient interaction

A

Take with low fat breakfast <=8 grams

Fat may interfere with absorption

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13
Q

Streptozocin/zanosar drug/nutrient interaction

A

May cause hypoglycemia

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14
Q

Provenge/ sipuleucelT drug/nutrient interaction

A

Avoid caffeine in day of leukapheresis

Drink more water prior to days treatments and eat high calcium breakfast

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15
Q

Bortezomib/ velcade drug/nutrient interaction

A

Avoid green tea, especially liquid and capsule forms

Avoid grapefruit

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16
Q

Capecitabine/ xeloda drug/nutrient interaction

A

Take within 30min of meal with glass of water

Vitamin B6 may prevent hand foot syndrome - 50-100mg 2-3x per day

Monitor if on warfarin

17
Q

Cetuximab/Erbitux drug/nutrient interaction

A

Monitor serum Mg and Ca levels

18
Q

Cisplatin /Platinol drug/nutrient interaction + side effects

A

Rigorous hydration is needed to prevent nephrotoxicity

Monitor BUN Cr, and serum electrolytes (Mg Ca Na K) -hold if Cr (above 1.3)

SIADH

supplements that may benefit: milk thistle, fish oil + caffeinated green tea, selenium or mannitol (prevent AKI), curcumin

19
Q

Cyclophosphamide/ cytoxan drug/nutrient interaction

A 
Vigorous hydration (3L per day)
Empty bladder every 2-3 hours

Mesna is given to prevent hemorrhagic cystitis (also used with ifosfamide)

20
Q

Deferasiox/Exjade drug/nutrient interaction

A

Contains lactose

May need lactase if diarrhea

21
Q

erlotinib/Tarceva

A

lung or pancreatic ca
protein targeted therapy
- avoid st johns wort + grapefruit
- may cause skin rash, cardiotoxicity and gastrointestinal complaints (n/v/d/anorexia)

22
Q

imatinib/gleevec

A

CML, GIST, MDS, ALL
protein targeted therapy
- avoid st johns wort + grapefruit
- may cause skin rash, cardiotoxicity, and gastrointestinal complaints (n/v/d/anorexia)

23
Q

cytoxan/cyclophosphamide

A

SIADH, n/v

monitor vitamin D for deficiency

24
Q

irinotecan/Camptosar

A

diarrhea

25
Q

tacrolimus

A

immunosuppressant

- n/v, renal toxicity, low Mg and high K

26
Q

sirolimus

A

immunosuppressant

- hypertriglyceridemia

27
Q

cytokine treatments

A

interleukin-2, interferon - alpha

- flu symptoms, fatigue, anorexia, myelosuppression, n/v/d, renal and cardiotoxicity

CSO Study Cards (10 decks)

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