Chemo Drugs Flashcards
What are the types of chemo drugs?
Antimetabolites, Alkylating Agents, Cytotoxic Antibiotics, Monoclonal Antibodies, PKI’s, Hormones
Trastuzumab is a ? and bind to what? What does is it used in treatment of?
Monoclonal Antibody and HER2, treats breast cancer!
Trashy girls with big boobs have big bellies
Bevaciumab is a ? and binds to what? What is it used in treatment of?
Monoclonal Antibody and VEGF, treats colorectal cancer!
Bev likes veg and that is good for colon!
Which drugs bind to CD20?
Rituximab and Ofatumab
What do Rituximab and Ofatumab treat?
NHL, CLL / Ofatumab CLL only
Platinum Compounds, Nitrogens, Bulsufan and Procarbazine are what type of chemo drugs?
Alkylating agents!
Nitrogen Mustard and Nitrosaureaous do what to DNA?
Block DNA synthesis and prevent DNA synthesis by damaging the DNA crosslink
Secret agents use nitrogen to block DNA/ cell division
Platinum compounds do what to DNA? What do they bind to?
Block DNA synthesis and prevent DNA synthesis by damaging the DNA crosslink! G A U purian bases!
Platinum compounds drugs are?
TIN’s Cisplatin, Carbplatin, Oxyplatin
Alkys, drink out of tinnies!
Why is Carbplatin preferred to cisplatin?
Less side effects!
Oxyplatin treats what?
Colorectal
Cisplatin and Carbplatin treat what?
Testes, Ovaries and bladder
What is cyclophosphomide and what are its side effects?
Nitrogen Mustard, sterile and AML
Psychos like mustard on their omas
What are the three Antimetabolites?
Folate Antagonists, Pyrimide Analogues, Purine Analogues
Methatrexate is a what? What does it inhibit?
Folate antag, DHFR!
Meth heads take folic acid by mouth!
Pyrimide analogues complete with what? What drugs are they?
C and T bases, BINE drugs! Capecitabine, Cytrarabine, Gemcitabine, Flourouracil
Purine Analogues ?
Compete with A and G,
Mercaptopurine/tioguanine Pentostatin, Fludarabine
Leukemia
MAB drugs are what?
Monoclonial antibodies
Bulsufan treats what, is what type of drug and selective for what?
Leukemia, alkylating agent, bone marrow!
Luke gets on the bus with a boner!
DoxirubiCIN is a what? What is its mechanism of action
CYTOTOXIC ANTIBODY, Intercalates w/ DNA & binds the helical groovePREVENTS TOPOISOMERASES FROM RESEALING HELICAL BREAKS
It is a TOPOISOMERASE 2 POISON
It causes free radical formation - destructive to cells
Bleomycin, Dactinomycin (paeds), Mitomycin are active against what?
None dividing cells, such as in Testicular cancer, squamous cell cancer, Hodgkin disease, and non-Hodgkin lymphoma
Vinca Alkoloids!
Plant derivative, few side effects, periwinkle, prevents spindle formation, Vincristine, Vinblastine, Vindesine! Lymph, Leukemia, Omas. Wilms tumour!
Vinny gets spinny when he smokes his green he meets his mate Will and goes oma!
What are Paclitaxel, Docetaxel and what do they treat?
Plant derivative, Taxanes, treat breast and ovaries! TAXELS Used with carbaplatin
Girls pay taxes especially when they eat carbs!
Why are glucocorticoids used?
Reduce side effects! Pred and Dexamethasone
