Chemo Drugs

Question 1

What are the types of chemo drugs?

Answer 1

Antimetabolites, Alkylating Agents, Cytotoxic Antibiotics, Monoclonal Antibodies, PKI’s, Hormones

Question 2

Trastuzumab is a ? and bind to what? What does is it used in treatment of?

Answer 2

Monoclonal Antibody and HER2, treats breast cancer!

Trashy girls with big boobs have big bellies

Question 3

Bevaciumab is a ? and binds to what? What is it used in treatment of?

Answer 3

Monoclonal Antibody and VEGF, treats colorectal cancer!

Bev likes veg and that is good for colon!

Question 4

Which drugs bind to CD20?

Answer 4

Rituximab and Ofatumab

Question 5

What do Rituximab and Ofatumab treat?

Answer 5

NHL, CLL / Ofatumab CLL only

Question 6

Platinum Compounds, Nitrogens, Bulsufan and Procarbazine are what type of chemo drugs?

Answer 6

Alkylating agents!

Question 7

Nitrogen Mustard and Nitrosaureaous do what to DNA?

Answer 7

Block DNA synthesis and prevent DNA synthesis by damaging the DNA crosslink
Secret agents use nitrogen to block DNA/ cell division

Question 8

Platinum compounds do what to DNA? What do they bind to?

Answer 8

Block DNA synthesis and prevent DNA synthesis by damaging the DNA crosslink! G A U purian bases!

Question 9

Platinum compounds drugs are?

Answer 9

TIN’s Cisplatin, Carbplatin, Oxyplatin

Alkys, drink out of tinnies!

Question 10

Why is Carbplatin preferred to cisplatin?

Answer 10

Less side effects!

Question 11

Oxyplatin treats what?

Answer 11

Colorectal

Question 12

Cisplatin and Carbplatin treat what?

Answer 12

Testes, Ovaries and bladder

Question 13

What is cyclophosphomide and what are its side effects?

Answer 13

Nitrogen Mustard, sterile and AML

Psychos like mustard on their omas

Question 14

What are the three Antimetabolites?

Answer 14

Folate Antagonists, Pyrimide Analogues, Purine Analogues

Question 15

Methatrexate is a what? What does it inhibit?

Answer 15

Folate antag, DHFR!

Meth heads take folic acid by mouth!

Question 16

Pyrimide analogues complete with what? What drugs are they?

Answer 16

C and T bases, BINE drugs! Capecitabine, Cytrarabine, Gemcitabine, Flourouracil

Question 17

Purine Analogues ?

Answer 17

Compete with A and G,
Mercaptopurine/tioguanine Pentostatin, Fludarabine
Leukemia

Question 18

MAB drugs are what?

Answer 18

Monoclonial antibodies

Question 19

Bulsufan treats what, is what type of drug and selective for what?

Answer 19

Leukemia, alkylating agent, bone marrow!

Luke gets on the bus with a boner!

Question 20

DoxirubiCIN is a what? What is its mechanism of action

Answer 20

CYTOTOXIC ANTIBODY, Intercalates w/ DNA & binds the helical groovePREVENTS TOPOISOMERASES FROM RESEALING HELICAL BREAKS
It is a TOPOISOMERASE 2 POISON
It causes free radical formation - destructive to cells

Question 21

Bleomycin, Dactinomycin (paeds), Mitomycin are active against what?

Answer 21

None dividing cells, such as in Testicular cancer, squamous cell cancer, Hodgkin disease, and non-Hodgkin lymphoma

Question 22

Vinca Alkoloids!

Answer 22

Plant derivative, few side effects, periwinkle, prevents spindle formation, Vincristine, Vinblastine, Vindesine! Lymph, Leukemia, Omas. Wilms tumour!
Vinny gets spinny when he smokes his green he meets his mate Will and goes oma!

Question 23

What are Paclitaxel, Docetaxel and what do they treat?

Answer 23

Plant derivative, Taxanes, treat breast and ovaries! TAXELS Used with carbaplatin
Girls pay taxes especially when they eat carbs!

Question 24

Why are glucocorticoids used?

Answer 24

Reduce side effects! Pred and Dexamethasone

Question 25

Imatinib, Dasatinib, Nilotinib are what? What do they treat?

Answer 25

Protein Kinase Inhibitors, NIBS, CML

Question 26

Carmustnine, (BCNU), Lomustine (CCNU) are used in the treatment of?

Answer 26

CNS cancers! Agent Car and Agent Lom stop attacks on CNS