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Pharmacology > Chemo Drugs > Flashcards

Chemo Drugs Flashcards

1
Q

Cyclophosphamide

A

Alkylating agent
Oral or injectable
Hepatic metabolism
Sterile hemorrhagic cystitis

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2
Q

Chlorambucil

A

Alt to cyclophosphamide
Oral!
Alkylating agent

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3
Q

Melphalan

A

Alkylating agent

Tx multiple myeloma

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4
Q

Lomustine

A 
Nitroureas
Oral only 
Side effects: thrombocytopenia, hepatotoxicity 
Crosses BBB 
Tx mast cell tumors, lymphoma
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5
Q

Procarbazine

A

Used in MOPP protocol for lymphoma

Hydrazine

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6
Q

Temozolomide

A

Hydrazine

Oral and crosses BBB

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7
Q

cisplatin

A 
Metal salt 
Cell cycle non specific 
Tx osteosarcoma 
Intralesional, intracavitary 
Fatal pulmonary edema in cats 
Nephro and ototoxic to dogs 
Need saline diuresis!!
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8
Q

Carboplatin

A 
Metal salt 
Safe in cats!!! 
Less nephrotoxic - no diuresis needed 
Less expensive generic!! 
Mylosuppressive
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9
Q

5-FU

A

Anti metabolites - S-phase specific
Topical available
Neurotoxic to cats

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10
Q

Gemcitabine - Gemzar

A

Antimetabolite - S phase specific

Thrombocytopenia and retinal hemorrhage

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11
Q

Doxorubicin

A 
Anti tumor antibody - cell cycle nonspecific 
VESICANT 
Tx - lymphoma, osteosarcoma 
Cardio toxic in dogs 
Nephrotoxic in cats
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12
Q

Mitoxantrone

A

Anti tumor antibodies
Decreased cardio toxicity
Myelosuppressive
Good for bladder cancer

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13
Q

Vincristine

A

Vinca alkaloid - M phase specific

Side effects > peripheral neuropathy, constipation, increases platelet count, vesicant

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14
Q

Vinblastine

A

Vinca - M phase specific.
Tx mast cell tumors
Don’t confuse with vincristine!!

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15
Q

L-asparaginase

A 
G1 specific 
Derived from e. Coli 
Can cause hypersensitivity reaction and pancreatitis 
Limited availability 
Good for lymphoma > spares the marrow
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16
Q

Mechlorerhamine

A

Alkylating agent
Nitrogen mustard gas derivative
Used in MOPP protocol for lymphoma

Pharmacology (4 decks)

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