Chemical Connections Lipids 2-F

Question 1

This inflammation response is mediated by

Answer 1

prostaglandin molecules

Question 2

Prostaglandin molecules are derivatives of

Answer 2

arachidonic acid, a 20:4 fatty acid

Question 3

Anti-inflammatory steroid drugs such as

Answer 3

cortisone

Question 4

is the oldest and best known NSAID.

Answer 4

Aspirin

Question 5

which were initially prescription medications, are now commonly used over-the-counter anti-inflamma-tory drugs

Answer 5

Ibuprofen (Advil) and naproxen (Aleve)

Question 6

The most often prescribed prescription NSAID is

Answer 6

diclofenac

Question 7

also produces prostaglandins that induce the production of a protective mucous coating for the stomach lining (a desirable situation)

Answer 7

COX-1

Question 8

is responsible for the production of additional prostaglandin molecules involved in inflammatory diseases such as arthritis (an undesirable situation).

Answer 8

The COX-2 enzyme

Question 9

inhibit both COX-1 and COX-2 enzymes.

Answer 9

Aspirin, ibuprofen, naproxen, and diclofenac

Question 10

The best known of these COX-2 inhibitors are

Answer 10

Vioxx and Celebrex,

Question 11

was withdrawn from the market because of concerns relating to heart attacks and strokes

Answer 11

Vioxx