Chem MOAs

Question 1

Botulinus toxin action

Answer 1

BLOCKs release of Ach from PREsynapic terminals

• *“from bad BOTtle of food”
• B–> Botulin BLOCKS release”

Question 2

Botulinus toxion’s effect on NM transmission

Answer 2

total blockade
flaccid paralysis
“floppy baby”

Question 3

Curare (arrow poison) action

Answer 3

Competes with Ach for receptor on MOTOR end plate

C–> Curare COMPETES with

Question 4

Curare’s effect on NM transmission

Answer 4

decrease EPP

Paralysis of resp muscles –> death

Question 5

Neostigmine action

Answer 5

inhibits acetyl cholinesterase

Question 6

Neostigmine’s effect on NM transmission

Answer 6

prolongs and enhances action of ACh at muscle end plate

Question 7

Hemicholinium’s action

Answer 7

Blocks re-uptake of choline into presynaptic terminal

Question 8

Hemicholinium’s effects on NM transmission

Answer 8

Depletes ACh stores from presynamptic terminals

Question 9

Aminoglycosides action

and Lamort Eaton Syndrome

Answer 9

Antibodies BLOCK Ca ++ channels

Question 10

Aminoglycosides Effect on NM transmission

and Lamort Eaton Syndrome

Answer 10

No release of ACh

Question 11

Black widow spider venom action

Answer 11

excessive release of ACh

Question 12

Black widow spider venom effects on NM Transmission

Answer 12

convulsions

Question 13

antibody-induced degradation of ACh receptors is seen in

Answer 13

myasthenia gravis

Question 14

Neurotransmitter synthesis of Acetylcholine:

Answer 14

Acetyl CoA + Choline —–> acetylcholine

Question 15

Neurotransmitter synthesis of Norepinephrine:

Answer 15

Tyrosine -->
L-Dopa --->
Dopamine-->
Norepinephrine---> 
Epinephrine

Question 16

Neurotransmitter synthesis of Dopamine:

Answer 16

Tyrosine –>
L-Dopa —>
Dopamine

Question 17

Neurotransmitter synthesis of Epinephrine:

Answer 17

Tyrosine -->
L-Dopa --->
Dopamine-->
Norepinephrine---> 
Epinephrine

Question 18

The rate limiting step in NT synthesis of Dopamine/Nor/Epi is:

Answer 18

1. Tyrosine hydoxylase

Question 19

Norepinephrine is metabolized by

Answer 19

MAO monoamine oxidase

Question 20

Small molecule, rapidly acting NTs are:

Answer 20

1. Ach,
2. Aspartame,
3. Dopamine,
4. Epi,
5. GABA,
6. Glycine,
7. Glutamate,
8. Histamine,
9. Norepi,
10. Nitric oxide (NO)

Question 21

Neuropeptides, slowly acting transmitters are:

Answer 21

• Hypothalamic hormones
• Pituitary hormones
• Peptides: Substance P, gastrin, Insulin, glucagon
• Angiotensin II
• Bradykinin