CHD, MI and embolism Flashcards
How does coronary artery disease present?
- Sudden cardiac death
- Acute coronary syndrome
Acute MI
Unstable angina - Stable angina pectoris
- Heart failure
- Arrhythmia
What two main categories does sudden onset chest pain fall under?
- MI
- Progressive unstable angina
What are the consequences of CAD?
- Damage of the heart muscle leading to heart failure (cannot pump)
- if there is scar tissue formation within the myocardium then this is an important substrate for the development of arrhythmia which leads to sudden cardiac death
Describe the epidemiology of CVD?
- worldwide
- mortality
- death number worldwide
- women?
- age?
- number one cause of death worldwide
- leading cause of death in women
- leading cause of death in over 70
- affects more women
- mortality has decreased by 50% over 50 years
- 17 million death yearly
UK burden of CHD
- 88,000 CHD deaths in UK yearly
- Commonest cause of premature death
- mortality falling but higher than rest of Europe
What are the risk factors of CHD?
- tobacco
- physical inactivity
- alcohol abuse
- hypertension
- obesity
- diabetes
- hyperlipidaemia
What is angina pectoris?
causes, relieved by?
- clinical diagnosis
- discomfort in chest, jaw, shoulders, arms or back
- provoked by stress or exertion
- rest or GTN (inorganic nitrate vasodilator)
Describe the epidemiology of stable angina
- incidence increasing
- 2 million cases in the UK
- affects more people as age increases
What is myocardial ischaemia?
- Mismatch between myocardial oxygen supply and demand
- Primary reduction in blood flow
- Inability to increase blood flow to match an increase in metabolic demand
What is the job of the coronary circulation?
- To make sure that over a wide range of perfusion pressures, flow remains constant - autoregulation
- To make sure that coronary blood flow matches myocardial demand
What is the purpose of investigations for stable CHD?
- To confirm the clinical diagnosis
- To assess risk of future adverse cardiovascular events (severity, heart function)
What are some of the categories of investigations into CHD?
Functional - demonstrate that there is an imbalance between supply and demand
Anatomical - look at anatomical severity of the narrowing within the artery then make an inference about how it is affecting flow
Some of these tests are invasive and others are not
Give examples of functional invasive and non invasive tests
invasive - FFR (guided pressure wire), iFR
non invasive - exercise ECG, stress echo, PET/CT
Give examples of anatomical invasive and non invasive tests
invasive - coronary angiogram
non invasive - CT coronary angiogram, CT coronary calcium score
What are the treatment strategies for CHD?
- prevent atherosclerosis progression and MI risk through education, lifestyle and aspirin/ACE inhibitors/statins
- reduce heart oxygen demand (meds to reduce heart rate, wall stress and metabolic modifiers)
- improve blood supply (vasodilators, revascularisation)
UK MI epidemiology
- 124,000 per year
- 33,600 death yearly
- cost 3.6 billion yearly
Describe the functional anatomy of the coronary circulation
- Epicardial coronary arteries (those running on the surface) are conductance vessels that are dependent on arterial pressure.
- Overall coronary resistance is 50% in large arteries and 50% in the smaller arteries and capillaries.
- Seperated into: epicardial and intracardial components.
What is the effect of epicardial stenosis on resting TPR and blood flow?
- With stenosis in the epicardial compartment, the resistance here increases
- This is compensated to some degree by an increase in vasodilation (reduction in R) in the intramyocardial vessels, however, after around 70% stenosis, coronary blood flow decreases rapidly.
What is the coronary flow reserved and how is it calculated?
- The ratio of resting blood flow: blood flow achieved under maximal stress = coronary flow reserve
- This reserve is the ability of the coronary circulation to adapt to an increasing demand in the face of increasing stenosis
- Past 50% stenosis, the ability of the coronary circulation to increase blood supply in response to a vasodilator falls
Mechanisms of Myocardial Infarction- what causes interrupted blood flow to heart?
What are the ways in which mycoardial death occurs?
- Coronary plaque rupture (this is the most common cause of MI – 70-80% cases)
- Coronary plaque erosion
- Coronary dissection
- Oncosis – Ischaemic cell death
- Apoptosis – Programmed cell death
What are the types of thrombus and how is it formed?
WHITE Thrombus:
- Platelet rich.
- Common in arterial thrombosis.
- Treated by anti-platelet therapy.
RED thrombus:
- Fibrin rich (with trapped erythrocytes).
- Common in venous thrombosis.
- Treated by anti-coagulants.
Thrombus Formation:
Tissue factor plays a key role and is made by either the plaque itself or ischaemic muscle cells.
TF can trigger the cascade of factor activation leading to coronary thrombosis (10a and 2a are important).
What is the effect of coronary stenosis on sheer stress and blood flow type?
The blood focuses to go into the narrowing which slows the blood flow down and decreases shear stress, then inside the stenosis, a high shear stress exists where the blood accelerates and then upon exiting, turbulent flows are created which decreases shear stress which can have an affect on deregulating the endothelium
What is the universal definition of an acute myocardial infarction?
Detection of a rise or fall in a biomarker (troponin) with at least one value >99th percentile reference limit and at least one of: symptoms, ECG changes or heart muscle change
What are some of the symptoms of MI used in the definition?
- Symptoms suggestive of ischaemia
- New or presumed new ST-T changes or LBBB (left branch bundle block) on ECG
- Development of pathological Q wave on ECG
- Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality
- Identification of intracoronary thrombus or angiography autopsy
