ChatGPT? Flashcards
1
Q
Why do we need paired-end sequencing to detect translocations?
A
Paired-end sequencing reads from opposite ends of a DNA fragment, helping to identify structural variations like translocations.
2
Q
How can we detect aneuploidy in a tumor?
A
Aneuploidy can be detected by analyzing sequencing data for changes in chromosome copy number.
3
Q
Which organelles contain DNA?
A
Organelles like mitochondria and chloroplasts contain DNA.
4
Q
Why is it important to know which organelles contain DNA in relation to WGS?
A
DNA from organelles can contaminate whole genome sequencing (WGS) results, potentially misleading analysis.
5
Q
What genomic effects are observed with BRCA2 deficiency?
A
BRCA2 deficiency leads to random point mutations and insertions/deletions in the genome.
