ChatGBT Questions Flashcards

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1
Q

A 68-year-old man with a history of hypertension and hyperlipidemia presents to the emergency department with sudden onset of severe chest pain radiating to his left arm, beginning 30 minutes ago while resting. He appears pale and diaphoretic. His blood pressure is 160/90 mmHg, heart rate 110 bpm, and respiratory rate 22 breaths per minute. An ECG shows ST elevation in leads II, III, and aVF. Which of the following is the most appropriate next step in management?**
- A. Administer sublingual nitroglycerin
- B. Perform immediate coronary angiography
- C. Give aspirin and clopidogrel
- D. Obtain a chest X-ray**

A

B. Perform immediate coronary angiography

The patient’s symptoms and ECG findings are indicative of an ST-segment elevation myocardial infarction (STEMI), specifically involving the inferior wall given the leads affected. Immediate coronary angiography is crucial as it is part of revascularization therapy, which is the recommended treatment for STEMI patients to restore blood flow and minimize myocardial damage.

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2
Q

A 55-year-old woman presents with shortness of breath and palpitations. She has a history of type 2 diabetes and atrial fibrillation. Her blood pressure is 140/85 mmHg, heart rate is irregularly irregular at 120 bpm, and her lungs are clear. ECG confirms atrial fibrillation with rapid ventricular response. What is the most appropriate initial treatment?**
- A. Metoprolol
- B. Amiodarone
- C. Digoxin
- D. Warfarin

A

A. Metoprolol

Metoprolol is indicated as it helps in controlling the heart rate by slowing the AV nodal conduction, which is beneficial in atrial fibrillation with rapid ventricular response. This beta-blocker is effective in reducing symptoms and stabilizing the patient’s condition.

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3
Q

A 72-year-old man with a history of chronic heart failure is brought to the ER with worsening dyspnea and ankle swelling. Physical examination reveals jugular venous distention, pulmonary rales, and peripheral edema. Chest X-ray shows cardiomegaly and pulmonary congestion. What is the most appropriate initial management?**
- A. Start IV furosemide
- B. Perform endotracheal intubation
- C. Administer subcutaneous enoxaparin
- D. Give oral prednisone

A

A. Start IV furosemide

IV furosemide is appropriate for acute decompensated heart failure with signs of fluid overload as evidenced by dyspnea, rales, and peripheral edema. It provides rapid diuresis, reducing fluid congestion and improving symptoms.

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4
Q

A 63-year-old female presents with dizziness and a fainting spell while gardening. She reports no previous cardiac history but has a mild headache. Her pulse is 45 bpm, and blood pressure is 110/70 mmHg. ECG shows a regular, slow rhythm with absent P waves and wide QRS complexes. What is the likely diagnosis?**
- A. Second-degree AV block
- B. Sinus bradycardia
- C. Third-degree AV block
- D. Ventricular tachycardia

A

C. Third-degree AV block

The ECG findings and clinical presentation suggest a third-degree AV block (complete heart block), where there is no association between P waves and QRS complexes. This condition often requires urgent pacing.

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5
Q

A 58-year-old man presents to the emergency department complaining of sudden, severe back pain and a syncopal episode. His blood pressure is 90/60 mmHg, and he has a pulsatile abdominal mass. His extremities are cool and pale. Which of the following is the most likely diagnosis?**
- A. Acute pancreatitis
- B. Ruptured aortic aneurysm
- C. Myocardial infarction
- D. Pulmonary embolism

A

B. Ruptured aortic aneurysm

The presence of a pulsatile abdominal mass, hypotension, and the described symptoms are highly suggestive of a ruptured aortic aneurysm, which is a surgical emergency. Immediate imaging and surgical consultation are required.

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6
Q

A 50-year-old man with known peripheral arterial disease presents with sudden onset of cold, painful right leg. The leg appears pale and pulseless. What is the most likely diagnosis, and what is the immediate management step?**
- A. Deep vein thrombosis, start anticoagulation
- B. Acute arterial occlusion, immediate surgical evaluation
- C. Chronic venous insufficiency, prescribe compression stockings
- D. Cellulitis, administer IV antibiotics

A

B. Acute arterial occlusion, immediate surgical evaluation

Acute arterial occlusion presents with the ‘five Ps’: Pain, Pallor, Pulselessness, Paresthesia, and Paralysis. Immediate surgical evaluation is crucial for possible revascularization to save the limb.

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7
Q

A 45-year-old man presents with crushing chest pain, nausea, and sweating. His ECG shows ST elevations in the anterior leads. His troponin I level returned elevated. Which of the following medications should be administered first?**
- A. Oral aspirin
- B. IV metoprolol
- C. Sublingual nitroglycerin
- D. Oral atorvastatin

A

A. Oral aspirin

Aspirin is given immediately in cases of suspected myocardial infarction to reduce cardiac event-related mortality by inhibiting platelet aggregation, thus preventing further thrombus formation.

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8
Q

A 70-year-old woman with no significant medical history suddenly collapses while shopping. Bystanders report she was complaining of severe chest pain before collapsing. On arrival, she is pulseless and CPR is initiated. The monitor shows ventricular fibrillation. What is the immediate next step?**
- A. Administer IV amiodarone
- B. Perform defibrillation
- C. Insert an oropharyngeal airway
- D. Administer IV epinephrine

A

B. Perform defibrillation

Immediate defibrillation is the most effective treatment for ventricular fibrillation, especially in the context of cardiac arrest following a suspected myocardial infarction.

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8
Q

A 60-year-old woman with a history of rheumatic heart disease presents with acute shortness of breath, orthopnea, and paroxysmal nocturnal dyspnea. Her ECG shows atrial fibrillation with rapid ventricular rate. What is the most likely exacerbating factor for her symptoms?**
- A. Chronic obstructive pulmonary disease
- B. Acute decompensated heart failure
- C. Acute renal failure
- D. Thyroid storm

A

B. Acute decompensated heart failure

Given the history of rheumatic heart disease, her symptoms are indicative of acute decompensated heart failure, likely exacerbated by the onset of atrial fibrillation with rapid ventricular rate, which compromises cardiac efficiency.

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9
Q

A 54-year-old male with a history of smoking and hypertension presents with sudden onset of tearing chest pain radiating to his back. His blood pressure is 180/120 mmHg. A chest X-ray shows a widened mediastinum. What is the most appropriate diagnostic test to confirm the suspected diagnosis?**
- A. Transthoracic echocardiogram
- B. CT scan of the chest with contrast
- C. MRI of the chest
- D. Coronary angiography **

A

B. CT scan of the chest with contrast

The clinical presentation is suggestive of an aortic dissection. A CT scan of the chest with contrast is the diagnostic test of choice for confirming the presence of an aortic dissection, as it provides detailed images of the aorta and can identify the extent of the dissection.

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10
Q

A 65-year-old male with a history of congestive heart failure and diabetes mellitus presents with progressive shortness of breath, fatigue, and a weight gain of 5 kg over the past week. Physical examination reveals rales halfway up both lung fields, jugular venous distention, and 3+ pitting edema of the lower extremities. Which therapeutic intervention is most appropriate to administer first?**
- A. Oral furosemide
- B. Intravenous furosemide
- C. Intravenous nitroglycerin
- D. Oxygen therapy

A

B. Intravenous furosemide

The patient presents with acute decompensated heart failure with signs of significant volume overload. Intravenous furosemide is indicated for rapid diuresis to relieve symptoms of fluid congestion and improve respiratory status.

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11
Q

A 39-year-old woman with no significant medical history presents with palpitations and light-headedness. Her pulse is 160 bpm, and ECG shows a narrow complex tachycardia without visible P waves. Vagal maneuvers have been attempted without success. What is the most appropriate pharmacologic treatment?**
- A. IV adenosine
- B. Oral beta-blockers
- C. IV amiodarone
- D. Oral digoxin

A

A. IV adenosine

The patient likely has supraventricular tachycardia (SVT). IV adenosine is the drug of choice for rapid termination of SVT due to its ability to transiently block the AV node.

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12
Q

A 70-year-old female with a history of atrial fibrillation is brought in by ambulance after being found unconscious at home. On examination, she is hypotensive and bradycardic. ECG shows a wide complex bradycardia with no discernible P waves. What is the most appropriate initial management?**
- A. Administer IV atropine
- B. Immediate electrical cardioversion
- C. Placement of a transcutaneous pacemaker
- D. Administer IV dopamine

A

C. Placement of a transcutaneous pacemaker

The patient presents with symptomatic bradycardia likely due to high-grade AV block or ventricular escape rhythm. The placement of a transcutaneous pacemaker is indicated to provide stable cardiac output until a more permanent solution is implemented.

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13
Q

A 58-year-old male with a history of chronic smoking and chronic obstructive pulmonary disease presents with acute onset of severe chest pain and dyspnea. Examination reveals a hypotensive patient with a loud diastolic murmur best heard over the right sternal border. Which of the following is the most likely diagnosis?**
- A. Acute myocardial infarction
- B. Aortic dissection
- C. Acute pulmonary embolism
- D. Aortic regurgitation

A

B. Aortic dissection

The combination of severe chest pain, hypotension, and a diastolic murmur suggests an aortic dissection, which may involve the aortic valve leading to acute aortic regurgitation as a complication.

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14
Q

A 55-year-old male is brought to the ER with chest pain and diaphoresis that started while mowing the lawn. His past medical history is significant for hypercholesterolemia. ECG shows ST elevations in leads V2-V4. Which enzyme is most specific for diagnosing an acute myocardial infarction in this setting?**
- A. Creatine kinase-MB
- B. Troponin I
- C. Aspartate transaminase (AST)
- D. Lactate dehydrogenase (LDH)

A

B. Troponin I

Troponin I is the most specific and sensitive marker for myocardial injury and is essential for the diagnosis of myocardial infarction, especially in patients presenting with classic symptoms and ECG changes.

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15
Q

A 48-year-old woman presents with sudden onset of shortness of breath and right-sided chest pain following a long airplane flight. She is tachycardic and hypoxic. A D-dimer test is markedly elevated. What is the most appropriate next step in management?**
- A. Immediate administration of therapeutic anticoagulation
- B. Perform a ventilation-perfusion (V/Q) scan
- C. Obtain a spiral CT scan of the chest
- D. Administer supplemental oxygen and observe

A

C. Obtain a spiral CT scan of the chest

The clinical presentation is suggestive of a pulmonary embolism. A spiral CT scan of the chest is the most appropriate diagnostic test to confirm the diagnosis and guide further management, especially in a hemodynamically stable patient.

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16
Q

A 62-year-old male with a known history of aortic stenosis presents complaining of dizziness and syncope. Examination reveals a systolic ejection murmur best heard at the right second intercostal space. Which of the following is the most appropriate diagnostic test to assess the severity of his condition?**
- A. Transthoracic echocardiogram
- B. Cardiac catheterization
- C. Holter monitor
- D. Exercise stress test

A

A. Transthoracic echocardiogram

A transthoracic echocardiogram is the best initial test to assess the severity of aortic stenosis, evaluate valve anatomy, and measure hemodynamic parameters such as gradient and valve area.

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17
Q

A 50-year-old male with a history of hypertension presents with acute tearing pain radiating to his back and a blood pressure discrepancy between arms. What is the most likely diagnosis and the best initial imaging study to confirm it?**
- A. Acute myocardial infarction, echocardiogram
- B. Aortic dissection, CT angiography
- C. Pulmonary embolism, V/Q scan
- D. Pericarditis, ECG

A

B. Aortic dissection, CT angiography

The symptoms suggest an aortic dissection. A CT angiography is the most appropriate imaging study to confirm the diagnosis as it provides detailed images of the aorta and can show the presence of a dissection flap and involvement of branch vessels.

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18
Q

A 44-year-old female presents to the emergency department with severe chest pain and a history of systolic heart failure. ECG shows no new changes. BNP levels are elevated. Which of the following is the most likely cause of her chest pain?**
- A. Acute myocardial infarction
- B. Acute coronary syndrome
- C. Acute exacerbation of heart failure
- D. Pulmonary embolism

A

C. Acute exacerbation of heart failure

In patients with systolic heart failure presenting with chest pain and elevated BNP, acute exacerbation of heart failure should be considered as a probable cause, especially in the absence of new ECG changes.

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19
Q

A 68-year-old male with a history of diabetes and smoking presents with sudden onset of severe abdominal pain and back pain. His blood pressure is 180/110 mmHg. Examination reveals a pulsatile abdominal mass. What is the most likely diagnosis and the immediate step to take?**
- A. Acute pancreatitis, administer IV fluids
- B. Abdominal aortic aneurysm, urgent surgical referral
- C. Diverticulitis, administer antibiotics
- D. Kidney stones, perform a CT scan

A

B. Abdominal aortic aneurysm, urgent surgical referral

The presence of a pulsatile abdominal mass in a patient with risk factors such as diabetes and smoking, accompanied by severe pain and high blood pressure, strongly suggests an abdominal aortic aneurysm. Urgent surgical referral is necessary as this condition can lead to rupture, which is life-threatening.

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20
Q

A 54-year-old female with a past medical history of rheumatoid arthritis and no known cardiac history presents with new onset chest pain. She describes the pain as sharp and worsening with inspiration. She also reports a recent upper respiratory tract infection. Physical examination shows a friction rub. Which of the following is the most likely diagnosis?**
- A. Acute pericarditis
- B. Myocardial infarction
- C. Pulmonary embolism
- D. Costochondritis

A

A. Acute pericarditis

the clinical presentation of sharp pain worsening with inspiration and the presence of a pericardial friction rub strongly suggest acute pericarditis, likely precipitated by a recent viral infection.

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21
Q

A 67-year-old man presents with sudden onset of palpitations and light-headedness. His pulse is 200 bpm, and blood pressure is 110/70 mmHg. ECG shows a regular tachycardia with narrow QRS complexes. Vagal maneuvers are ineffective. What is the next best step in management?**
- A. Administer IV adenosine
- B. Immediate electrical cardioversion
- C. Administer oral beta-blockers
- D. Perform carotid sinus massage

A

A. Administer IV adenosine

The presence of a stable, narrow complex tachycardia unresponsive to vagal maneuvers suggests SVT. IV adenosine is effective for terminating SVT by temporarily blocking the AV node.

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22
Q

A 59-year-old male with a history of diabetes and hypertension presents to the emergency department complaining of sudden, severe left-sided chest pain radiating to the back. His blood pressure is 200/120 mmHg in the right arm and 180/110 mmHg in the left arm. A diastolic murmur is heard on auscultation. Which diagnostic test should be performed immediately?**
- A. Transthoracic echocardiogram
- B. CT angiography of the chest
- C. Coronary angiography
- D. X-ray of the chest

A

B. CT angiography of the chest

The symptoms of severe chest pain radiating to the back, differential blood pressure readings between arms, and a diastolic murmur suggest aortic dissection. A CT angiography of the chest is crucial for immediate diagnosis.

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23
Q

A 72-year-old woman presents to the ED with fatigue and an irregular heartbeat. She has a history of heart failure. Her ECG shows atrial fibrillation with a rapid ventricular response. Her blood pressure is 100/60 mmHg. Which of the following is the best initial treatment?**
- A. IV digoxin
- B. IV diltiazem
- C. Oral amiodarone
- D. IV metoprolol

A

B. IV diltiazem

Given her history of heart failure and presentation with atrial fibrillation with rapid ventricular response, IV diltiazem is appropriate for rate control. It helps decrease the ventricular rate without adversely affecting cardiac output.

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24
Q

A 45-year-old man with a history of hyperlipidemia presents with sudden onset of shortness of breath, right-sided chest pain, and hemoptysis. He recently returned from a long car trip. His oxygen saturation is 89% on room air. What is the most appropriate diagnostic test to confirm the suspected condition?**
- A. Chest X-ray
- B. D-dimer assay
- C. CT pulmonary angiography
- D. Echocardiogram

A

C. CT pulmonary angiography

The clinical scenario is highly suggestive of a pulmonary embolism. CT pulmonary angiography is the gold standard for diagnosing pulmonary embolism and should be performed immediately given the symptoms.

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25
Q

A 63-year-old female with a history of mitral valve prolapse presents to the emergency department with palpitations and a feeling of ‘heart flipping in her chest’. Her ECG shows occasional premature ventricular contractions (PVCs). What is the most appropriate management for this patient?**
- A. Immediate electrical cardioversion
- B. Administer IV beta-blockers
- C. Observation and reassurance
- D. Insert an implantable cardioverter-defibrillator

A

C. Observation and reassurance

In a patient with mitral valve prolapse who is experiencing occasional PVCs but no other signs of hemodynamic instability, the most appropriate management is observation and reassurance. PVCs are common and often benign.

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26
Q

A 76-year-old man with a history of chronic obstructive pulmonary disease presents with increasing dyspnea, cough, and a new finding of an S3 gallop on examination. His chest X-ray shows an enlarged cardiac silhouette. What is the most likely cause of his symptoms?**
- A. Acute bronchitis
- B. Exacerbation of COPD
- C. Acute decompensated heart failure
- D. Pneumonia

A

C. Acute decompensated heart failure

The presence of an S3 gallop and an enlarged cardiac silhouette on chest X-ray in a patient presenting with dyspnea and cough suggests acute decompensated heart failure.

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27
Q

A 60-year-old woman with a history of aortic stenosis presents with syncope. She is noted to have a systolic ejection murmur and her ECG shows left ventricular hypertrophy. What is the most appropriate next step in management?**
- A. Immediate surgical valve replacement
- B. Cardiac catheterization
- C. Holter monitoring
- D. Start beta-blockers

A

B. Cardiac catheterization

Cardiac catheterization can help assess the severity of aortic stenosis and guide decisions about timing for surgical valve replacement, which may be necessary given her symptom of syncope.

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28
Q

A 50-year-old man presents with acute onset of chest pain, dyspnea, and palpitations. He has a history of smoking 1 pack per day for 30 years. His ECG shows new T-wave inversions in leads II, III, and aVF. What is the most likely underlying cause of his presentation?**
- A. Acute myocardial infarction
- B. Chronic obstructive pulmonary disease (COPD)
- C. Acute pericarditis
- D. Pulmonary embolism

A

A. Acute myocardial infarction

New T-wave inversions in leads II, III, and aVF are suggestive of ischemia in the inferior wall of the heart, indicating an acute myocardial infarction, especially given his significant smoking history.

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29
Q

A 55-year-old man with a known history of hypertension and a previous myocardial infarction is brought to the ED with severe dizziness and weakness. His blood pressure is 80/50 mmHg, pulse is 50 bpm, and he is diaphoretic. His ECG shows a wide QRS complex. What is the most likely diagnosis?**
- A. Ventricular tachycardia
- B. Complete heart block
- C. Sinus bradycardia
- D. Atrial fibrillation with slow ventricular response

A

B. Complete heart block

the presentation of severe dizziness, weakness, hypotension, bradycardia, and wide QRS complexes is consistent with complete heart block, a serious condition requiring immediate pacing.

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30
Q

A 55-year-old woman with a history of rheumatoid arthritis presents with sudden onset of left knee pain and swelling after falling down stairs. Examination reveals warmth, erythema, and a palpable effusion. Which of the following is the most appropriate next step in management?**
- A) Immediate knee X-ray
- B) Intravenous antibiotics
- C) Oral NSAIDs and rest
- D) Arthrocentesis

A

D) Arthrocentesis

In a patient with rheumatoid arthritis presenting with acute knee pain, swelling, and signs of inflammation, arthrocentesis is critical to exclude septic arthritis, a potential emergency. An X-ray, while useful, would not provide immediate information regarding potential joint infection.

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31
Q

A 22-year-old male athlete complains of sudden, severe right shoulder pain and inability to move his arm after a collision during a football game. Physical examination shows anterior shoulder fullness and a squared off appearance of the deltoid. What is the most likely diagnosis?**
- A) Acromioclavicular joint injury
- B) Rotator cuff tear
- C) Anterior shoulder dislocation
- D) Clavicle fracture

A

C) Anterior shoulder dislocation

The description of anterior fullness and a squared-off deltoid contour is classic for an anterior shoulder dislocation, common in contact sports injuries.

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32
Q

A 30-year-old construction worker presents with low back pain after lifting heavy equipment. He reports numbness in his right leg. Straight leg raise test elicits right sciatic pain. Which diagnostic study will most likely confirm the suspected diagnosis?**
- A) X-ray of the lumbar spine
- B) MRI of the lumbar spine
- C) CT scan of the lumbar spine
- D) Electromyography (EMG)

A

B) MRI of the lumbar spine

MRI is the best choice for visualizing soft tissue details needed to diagnose herniated discs and nerve root impingement, likely in this case given the sciatica symptoms.

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33
Q

A 68-year-old female with a past medical history of osteoporosis falls at home and presents with hip pain. She is unable to bear weight. Physical examination reveals leg shortening and external rotation. Which is the most appropriate initial diagnostic test?**
- A) Pelvic X-ray
- B) Total body bone scan
- C) MRI of the hip
- D) CT scan of the pelvis

A

A) Pelvic X-ray

Pelvic X-rays are the first-line diagnostic tool for suspected hip fractures, especially after a low-energy trauma in an osteoporotic patient

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34
Q

A 45-year-old male presents with sudden onset of severe right great toe pain and swelling after a night of heavy drinking. On examination, the toe is red, hot, and extremely tender. Which of the following is the most likely diagnosis?**
- A) Septic arthritis
- B) Gout
- C) Fracture
- D) Cellulitis

A

B) Gout

Acute gouty arthritis is likely given the rapid onset, severe pain, and association with alcohol consumption, commonly affecting the great toe (podagra).

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35
Q

A 36-year-old woman presents complaining of recurrent, painful swelling of her knees and wrists. She has a butterfly rash on her face and reports severe fatigue. What is the most likely diagnosis?**
- A) Rheumatoid arthritis
- B) Systemic lupus erythematosus
- C) Psoriatic arthritis
- D) Osteoarthritis

A

B) Systemic lupus erythematosus

The combination of joint symptoms, a butterfly rash, and systemic symptoms like fatigue strongly suggests systemic lupus erythematosus.

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35
Q

A 20-year-old college student presents after twisting her ankle during basketball. She has significant swelling and bruising, and pain with weight-bearing. Ottawa ankle rules should be applied to determine the need for which of the following?**
- A) Immediate physiotherapy
- B) Ankle X-ray
- C) MRI of the ankle
- D) No imaging is necessary

A

B) Ankle X-ray

The Ottawa ankle rules suggest an X-ray is required in cases of ankle pain with bone tenderness and an inability to bear weight immediately after injury and in the emergency department.

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36
Q

A 58-year-old male with a history of back pain presents with new onset of bilateral thigh and groin pain. Physical examination reveals decreased range of motion in his hips. He has a history of smoking and chronic steroid use. Which condition is most likely responsible for his symptoms?**
- A) Osteoarthritis
- B) Avascular necrosis of the femoral heads
- C) Spinal stenosis
- D) Meralgia paresthetica

A

B) Avascular necrosis of the femoral heads

Chronic steroid use and smoking are risk factors for avascular necrosis, which can present with hip pain and reduced range of motion

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37
Q

A 50-year-old female presents to the emergency department with acute knee pain after a fall, notable for significant swelling. There is no fracture on X-ray. Her knee is aspirated, showing fat globules in the synovial fluid. What does this finding suggest?**
- A) Infection
- B) Rheumatoid arthritis
- C) Gout
- D) Fat embolism syndrome

A

D) Fat embolism syndrome

Fat globules in synovial fluid following trauma without a visible fracture suggest intra-articular fat, indicative of a bone marrow embolism potentially from a non-displaced bone fracture.

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38
Q

A 28-year-old male presents with a swollen, painful left wrist after falling on an outstretched hand. Examination shows tenderness over the ‘anatomical snuffbox.’ What is the most appropriate diagnostic test to order first?**
- A) Wrist X-ray
- B) MRI of the wrist
- C) Ultrasound of the wrist
- D) CT scan of the wrist

A

A) Wrist X-ray

Tenderness in the anatomical snuffbox after trauma is highly suggestive of a scaphoid fracture. An initial X-ray is appropriate to evaluate for this common injury.

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39
Q

A 32-year-old female presents to the emergency department with a swollen, painful right ankle after twisting it during a soccer game. Physical examination reveals tenderness over the lateral malleolus but no skin breaks. She is unable to bear weight. What is the most likely diagnosis?**
- A) Ankle sprain
- B) Lateral malleolus fracture
- C) Achilles tendon rupture
- D) Peroneal tendon dislocation

A

B) Lateral malleolus fracture

Given the tenderness over the lateral malleolus and the inability to bear weight, a fracture is highly probable, particularly in the setting of an acute inversion injury. An X-ray would confirm this diagnosis according to the Ottawa ankle rules.

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40
Q

A 40-year-old male presents with sudden onset of sharp, severe lower back pain after lifting a heavy object at work. He reports a sensation of a ‘pop’ in his back at the time of the injury. Examination reveals paraspinal muscle spasm without neurological deficit. Which of the following is the most appropriate initial management?**
- A) Immediate surgical referral
- B) MRI of the lumbar spine
- C) Prescription NSAIDs and muscle relaxants
- D) Bed rest for one week

A

C) Prescription NSAIDs and muscle relaxants

This presentation is consistent with acute lumbar strain. Initial management includes NSAIDs and muscle relaxants. Bed rest is discouraged as it may delay recovery, and imaging or surgical referral is not indicated unless neurological deficits are present.

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41
Q

A 70-year-old woman with a known history of osteoarthritis presents to the emergency room complaining of right hip pain that worsens with movement and is relieved by rest. She denies recent trauma. Physical examination shows limited range of motion of the right hip with pain on internal rotation. Which imaging modality is most appropriate for this patient?**
- A) X-ray of the hip
- B) MRI of the hip
- C) CT scan of the hip
- D) Ultrasound of the hip

A

A) X-ray of the hip

An X-ray is the first-line imaging study in patients presenting with symptoms suggestive of exacerbation of osteoarthritis, as it can reveal joint space narrowing, bone spurs, and other changes associated with the disease

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42
Q

A 24-year-old male complains of severe pain in his right wrist after falling off his skateboard and landing on his hand. Examination reveals tenderness and swelling over the scaphoid bone, but initial X-rays are negative. What is the most appropriate next step in management?**
- A) Discharge with analgesics and wrist brace
- B) Repeat X-rays in 10-14 days
- C) Immediate MRI
- D) Plaster cast immobilization and outpatient follow-up

A

C) Immediate MRI

With clinical suspicion of a scaphoid fracture and negative initial X-rays, an MRI is indicated as it can detect occult fractures not visible on X-rays. This ensures appropriate management to prevent complications like avascular necrosis.

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43
Q

A 15-year-old female volleyball player presents with anterior knee pain that worsens during activity, particularly when jumping. Physical examination reveals pain at the inferior pole of the patella. What is the most likely diagnosis?**
- A) Patellar tendinitis
- B) Patellar dislocation
- C) Meniscal tear
- D) Osgood-Schlatter disease

A

A) Patellar tendinitis

Known as ‘jumper’s knee,’ patellar tendinitis is common in athletes and presents with localized pain aggravated by activities that load the knee joint, such as jumping

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44
Q

A 55-year-old male with a history of chronic steroid use presents with sudden onset of severe right shoulder pain after reaching overhead. Physical examination reveals weakness in shoulder abduction. What is the most likely diagnosis?**
- A) Acute rotator cuff tear
- B) Shoulder impingement syndrome
- C) Adhesive capsulitis
- D) Biceps tendinitis

A

A) Acute rotator cuff tear

Chronic steroid use is a risk factor for tendon degeneration, which can lead to an acute rotator cuff tear, particularly under sudden stress. This diagnosis is supported by weakness in abduction, suggesting a tear involving the supraspinatus tendon.

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45
Q

A 49-year-old female presents with severe right wrist pain immediately following a fall onto her outstretched hand. There is noticeable deformity and swelling of the wrist. What is the most appropriate initial management?**
- A) Closed reduction and splinting
- B) Administer analgesia and order a wrist X-ray
- C) Immediate referral to orthopedics for surgery
- D) CT scan of the wrist

A

B) Administer analgesia and order a wrist X-ray

Initial management should focus on pain control and diagnostic imaging to assess the extent of the injury, which is critical for determining the appropriate intervention, including potential need for reduction or surgery.

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46
Q

A 29-year-old female reports a painful, swollen left knee after a twisting injury during a soccer game. She is unable to fully extend her knee. What is the most likely diagnosis?**
- A) Meniscal tear
- B) Anterior cruciate ligament (ACL) tear
- C) Patellar dislocation
- D) Medial collateral ligament (MCL) sprain

A

A) Meniscal tear

The inability to fully extend the knee, often referred to as a ‘locked knee,’ is a classic sign of a meniscal tear, particularly following a twisting injury during sports.

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47
Q

A 36-year-old man presents with neck pain and restricted movement following a rear-end collision while driving. He reports pain radiating down to his right arm. What is the most appropriate diagnostic test to order?**
- A) Neck X-ray
- B) CT scan of the neck
- C) MRI of the cervical spine
- D) Electromyography (EMG)

A

C) MRI of the cervical spine

An MRI is appropriate given the symptoms of radiating pain, which may indicate nerve root compression or other soft-tissue injuries not visible on X-rays or CT scans

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48
Q

A 60-year-old woman presents with right thigh pain after a minor fall. She has a history of chronic renal failure. Examination reveals pain with any attempt to move the hip, but no external injuries are visible. What is the most likely diagnosis?**
- A) Hip fracture
- B) Muscle strain
- C) Hematoma
- D) Renal osteodystrophy related fracture

A

A) Hip fracture

Given her age and the mechanism of injury, a hip fracture is highly likely and requires immediate X-ray imaging to confirm the diagnosis and guide further management.

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49
Q

A 19-year-old male presents to the emergency department after injuring his knee during a soccer game. He describes a “popping” sound followed by immediate swelling. Physical examination reveals a positive Lachman test. What is the most likely diagnosis?**
- A) Patellar fracture
- B) Meniscal tear
- C) Anterior cruciate ligament (ACL) tear
- D) Collateral ligament injury

A

C) Anterior cruciate ligament (ACL) tear

A ‘popping’ sound followed by immediate swelling and a positive Lachman test (which indicates anterior translation of the tibia relative to the femur) are classic indicators of an ACL tear.

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50
Q

A 38-year-old female presents with severe pain in her right wrist after slipping on ice. On examination, there is significant tenderness over the radial aspect of the wrist. An X-ray shows a fracture through the radial styloid. What is the most likely diagnosis?**
- A) Scaphoid fracture
- B) Distal radius fracture
- C) De Quervain’s tenosynovitis
- D) Ulnar styloid fracture

A

B) Distal radius fracture

A fracture through the radial styloid typically indicates a distal radius fracture, often referred to as a Chauffeur’s fracture, common in falls on an outstretched hand.

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51
Q

A 56-year-old male presents with acute onset of lower back pain after lifting a heavy object at home. The pain is localized to the lumbar region without radiation. He denies any previous history of similar pain. Physical examination reveals paraspinal tenderness without neurological deficit. What is the most appropriate management?**
- A) NSAIDs and physical therapy
- B) Immediate lumbar spine MRI
- C) Prescription opioids
- D) Epidural steroid injection

A

A) NSAIDs and physical therapy

This scenario suggests acute nonspecific low back pain, best managed initially with non-opioid analgesics such as NSAIDs and physical therapy to encourage mobility and strengthen the back.

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52
Q

A 24-year-old female runner presents with bilateral knee pain that worsens with running and descending stairs. Physical examination shows pain and swelling over the anterior aspect of both knees. Which condition is most likely responsible for her symptoms?**
- A) Patellar tendinopathy
- B) Patellofemoral pain syndrome
- C) Bursitis
- D) IT band syndrome

A

B) Patellofemoral pain syndrome

Patellofemoral pain syndrome is common in young athletes, especially females, presenting with pain localized to the anterior knee, exacerbated by activities that increase patellofemoral joint stress, such as running and stair climbing

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53
Q

A 60-year-old male with a history of prostate cancer presents with new onset of severe back pain. Radiographs reveal lytic lesions in the vertebral bodies. What is the most likely cause of his back pain?**
- A) Osteoporotic fractures
- B) Metastatic prostate cancer
- C) Multiple myeloma
- D) Acute herniated disc

A

B) Metastatic prostate cancer

Patients with a history of prostate cancer presenting with new severe back pain and lytic lesions on radiograph are highly suggestive of metastatic disease to the spine.

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54
Q

A 22-year-old female gymnast presents with acute onset of wrist pain following a fall during a routine. Examination shows tenderness over the scaphoid bone. An X-ray is negative for fracture. What is the next best step in management?**
- A) Discharge with follow-up if pain persists
- B) MRI of the wrist
- C) Splint and follow-up in one week
- D) Immediate referral to orthopedics

A

C) Splint and follow-up in one week

With clinical suspicion of a scaphoid fracture and an initially negative X-ray, it is appropriate to splint the wrist and arrange for close follow-up. An MRI may be considered if symptoms persist or worsen.

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55
Q

A 45-year-old male presents with shoulder pain after a motor vehicle accident. Examination reveals a dropped shoulder and inability to shrug against resistance. What is the most likely diagnosis?**
- A) Acromioclavicular joint separation
- B) Rotator cuff tear
- C) Brachial plexus injury
- D) Trapezius muscle injury

A

D) Trapezius muscle injury

Explanation: Inability to shrug the shoulder against resistance with a dropped shoulder appearance typically indicates a trapezius muscle injury, possibly involving the accessory nerve.

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56
Q

A 34-year-old male presents with acute right ankle pain and deformity after a basketball injury. Physical examination reveals tenderness, swelling, and instability of the ankle. What is the most appropriate immediate management?**
- A) Apply a compression wrap and elevate the ankle
- B) Perform a reduction in the emergency department
- C) Send the patient home with crutches and pain medication
- D) Immediate surgical referral

A

B) Perform a reduction in the emergency department

Clinical signs suggest a dislocated ankle, which requires immediate reduction in the emergency department to restore alignment and minimize vascular compromise.

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57
Q

A 53-year-old female presents with wrist pain following a slip on ice. Physical examination shows tenderness in the ‘anatomical snuffbox.’ The initial X-ray of the wrist is inconclusive. What is the next best step in management?**
- A) CT scan of the wrist
- B) Bone scan
- C) MRI of the wrist
- D) Splint and re-evaluate in 10-14 days

A

D) Splint and re-evaluate in 10-14 days

With tenderness in the anatomical snuffbox and an inconclusive initial X-ray, it is prudent to splint the wrist and schedule a follow-up, including a repeat X-ray, to rule out a scaphoid fracture, which can often be initially occult.

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58
Q

A 72-year-old male with a history of chronic obstructive pulmonary disease presents with acute right hip pain after a minor fall. He is unable to bear weight. An X-ray reveals no fracture. What is the most likely diagnosis?**
- A) Acute exacerbation of hip osteoarthritis
- B) Muscle strain
- C) Hip dislocation
- D) Insufficiency fracture

A

D) Insufficiency fracture

In elderly patients, particularly those with underlying conditions that may weaken bone (like COPD with long-term steroid use), an insufficiency fracture may occur even with minimal trauma and can be initially radiographically occult. MRI or CT may be needed to confirm the diagnosis.

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59
Q

A 43-year-old male with a history of alcohol abuse presents to the emergency department complaining of sudden onset of severe epigastric pain radiating to the back, nausea, and vomiting. His vital signs are: BP 110/70 mmHg, HR 120 bpm, T 37.6°C. On examination, he has epigastric tenderness. His serum lipase level is elevated. What is the most likely diagnosis?
- A) Acute cholecystitis
- B) Acute pancreatitis
- C) Peptic ulcer disease
- D) Gastroesophageal reflux disease

A

B) Acute pancreatitis

The patient’s history of alcohol abuse combined with the classic symptom of epigastric pain radiating to the back and elevated lipase confirms the diagnosis of acute pancreatitis. Acute cholecystitis and peptic ulcer disease typically do not cause pain that radiates to the back, and GERD does not correlate with elevated lipase levels.

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60
Q

A 57-year-old woman presents with a two-day history of right lower quadrant abdominal pain, fever, and leukocytosis. She mentions that the pain worsened with movement and is associated with nausea. On physical examination, you note tenderness and rebound in the right lower quadrant. What is the most appropriate next step in management?
- A) Order an abdominal ultrasound
- B) Perform a CT scan of the abdomen
- C) Administer intravenous fluids and observe
- D) Immediate exploratory laparotomy

A

B) Perform a CT scan of the abdomen

The clinical presentation is suggestive of acute appendicitis. A CT scan is the diagnostic tool of choice in adults to confirm the diagnosis and rule out other causes of right lower quadrant pain.

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61
Q

A 65-year-old man with a history of hypertension and chronic constipation presents with new-onset left-sided abdominal pain and a change in bowel habits. Physical examination reveals a distended abdomen and hyperactive bowel sounds. Which of the following is the most likely diagnosis?
- A) Diverticular disease
- B) Ischemic bowel disease
- C) Obstructive bowel disease
- D) Inflammatory bowel disease

A

A) Diverticular disease

Given the patient’s age and history of chronic constipation, diverticular disease with possible acute diverticulitis is likely, presenting with left-sided abdominal pain and altered bowel habits. Ischemic bowel disease typically presents with pain out of proportion to physical findings.

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62
Q

A 22-year-old college student comes to the emergency department with severe cramping abdominal pain, fever, and bloody diarrhea. He recently returned from a camping trip. Stool cultures are pending. Which of the following is the most likely pathogen?
- A) Escherichia coli O157:H7
- B) Salmonella
- C) Giardia lamblia
- D) Campylobacter jejuni

A

D) Campylobacter jejuni

Campylobacter jejuni is a common cause of bacterial enteritis, particularly in young adults and is often associated with consumption of contaminated water or food and recent travel or outdoor activities, such as camping.

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63
Q

A 55-year-old man with a history of peptic ulcer disease presents with vomiting of bright red blood. His BP is 90/60 mmHg and HR is 110 bpm. What is the initial most appropriate action?
- A) Oral administration of a proton pump inhibitor
- B) Endoscopic evaluation
- C) Administration of IV fluids and blood transfusion
- D) Immediate surgery

A

C) Administration of IV fluids and blood transfusion

This patient is presenting with signs of hypovolemic shock due to upper gastrointestinal bleeding, likely from a peptic ulcer. Immediate resuscitation with IV fluids and blood transfusion is necessary before further diagnostic steps such as endoscopy.

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64
Q

A 48-year-old female presents with jaundice, dark urine, and pruritus. Her liver function tests show elevated direct bilirubin and alkaline phosphatase. Which of the following is the most appropriate diagnostic test to confirm the suspected diagnosis?
- A) Hepatic ultrasound
- B) Liver biopsy
- C) ERCP
- D) Serum acetaminophen level

A

C) ERCP

The presentation is suggestive of cholestasis, possibly due to a biliary obstruction. ERCP (Endoscopic Retrograde Cholangiopancreatography) is appropriate for visualizing the biliary tree and identifying any obstructive lesion such as stones or tumors.

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65
Q

A 34-year-old male presents with sudden onset of right upper quadrant abdominal pain, fever, and vomiting. Physical examination shows tenderness in the right upper quadrant with a positive Murphy’s sign. What is the most likely diagnosis?
- A) Hepatitis
- B) Peptic ulcer
- C) Gallstones with acute cholecystitis
- D) Pancreatitis

A

C) Gallstones with acute cholecystitis

This classic presentation of right upper quadrant pain with a positive Murphy’s sign and systemic symptoms such as fever strongly suggests acute cholecystitis, typically associated with gallstones.

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66
Q

A 70-year-old woman presents with non-bloody diarrhea and a history of antibiotic use two weeks ago. Which of the following is the most appropriate treatment?
- A) Initiate loperamide
- B) Prescribe a course of ciprofloxacin
- C) Start metronidazole
- D) Oral vancomycin

A

D) Oral vancomycin

The patient’s history of recent antibiotic use and symptoms are suggestive of Clostridium difficile infection. Oral vancomycin is the treatment of choice for C. difficile infection.

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67
Q

A 26-year-old woman presents with acute lower abdominal pain and has a positive pregnancy test. She is hemodynamically stable, but her hCG levels are unusually high for the gestational age. What is the most likely diagnosis?
- A) Ectopic pregnancy
- B) Threatened abortion
- C) Normal early pregnancy
- D) Molar pregnancy

A

D) Molar pregnancy

The unusually high hCG levels and presentation of abdominal pain in a pregnant woman raise the suspicion of a molar pregnancy, which is characterized by abnormal trophoblastic growth.

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68
Q

A 60-year-old man with a history of atrial fibrillation and warfarin therapy presents with melena. His INR is 5.0. What is the most appropriate management to address his current condition?
- A) Increase the dose of warfarin
- B) Administer vitamin K
- C) Discontinue warfarin
- D) Perform a colonoscopy

A

B) Administer vitamin K

The patient has an elevated INR and symptoms of gastrointestinal bleeding, indicating warfarin over-anticoagulation. Vitamin K is used to reverse the effects of warfarin rapidly to manage the bleeding.

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69
Q

A 50-year-old male with a history of chronic smoking and alcohol use presents with acute onset of severe, sharp epigastric pain that worsens on lying flat and improves upon leaning forward. He also reports nausea without vomiting. Examination reveals epigastric tenderness without rebound. Which of the following is the most likely diagnosis?
- A) Acute myocardial infarction
- B) Acute pancreatitis
- C) Gastroesophageal reflux disease (GERD)
- D) Peptic ulcer disease

A

B) Acute pancreatitis

The patient’s presentation of severe epigastric pain that improves on leaning forward, along with a history of risk factors such as chronic smoking and alcohol use, strongly suggests acute pancreatitis. This condition often presents with pain that radiates to the back and is alleviated by sitting up and leaning forward.

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70
Q

A 29-year-old man presents with severe diarrhea, abdominal cramping, and fever after returning from a hiking trip in South America. He reports consuming local street food and untreated water. Stool examination is likely to reveal which of the following pathogens?
- A) Clostridium difficile
- B) Giardia lamblia
- C) Campylobacter jejuni
- D) Norovirus

A

B) Giardia lamblia

Giardia lamblia, a protozoan parasite, is commonly contracted through contaminated water, which fits the patient’s history of drinking untreated water during a trip to South America. It presents with diarrhea, cramps, and sometimes fever.

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70
Q

A 38-year-old female presents with acute right-sided abdominal pain and jaundice. Labs show elevated liver enzymes and bilirubin. Ultrasound reveals multiple gallstones and a dilated common bile duct. What is the most appropriate next step in management?
- A) Schedule for elective cholecystectomy
- B) Initiate broad-spectrum antibiotics
- C) Perform endoscopic retrograde cholangiopancreatography (ERCP)
- D) Provide symptomatic treatment only

A

C) Perform endoscopic retrograde cholangiopancreatography (ERCP)

Given the findings of gallstones and a dilated common bile duct in a patient presenting with jaundice and right-sided abdominal pain, ERCP is indicated to remove any obstructing stones in the bile duct and alleviate the obstruction.

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71
Q

A 45-year-old woman presents with a one-week history of progressive jaundice, pruritus, and pale stools. She has a history of rheumatoid arthritis and has been taking methotrexate. Which of the following is the most likely diagnosis?
- A) Viral hepatitis
- B) Drug-induced liver injury
- C) Autoimmune hepatitis
- D) Gallstone disease

A

B) Drug-induced liver injury

Methotrexate is known to potentially cause hepatotoxicity, especially in patients with pre-existing liver conditions or prolonged use, leading to symptoms like jaundice and pruritus. This patient’s symptoms are consistent with a drug-induced liver injury.

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72
Q

A 36-year-old male presents to the ED with lower abdominal pain and rectal bleeding. He reports a recent history of frequent antibiotic use for a skin infection. Colonoscopy shows pseudomembranes on the colon wall. Which treatment is most appropriate?
- A) Intravenous hydration and observation
- B) Oral vancomycin
- C) Initiation of antidiarrheal agents
- D) Broad-spectrum antibiotics

A

B) Oral vancomycin

The presence of pseudomembranes seen during colonoscopy and a history of recent antibiotic use suggest Clostridium difficile infection. Oral vancomycin is the treatment of choice for moderate to severe cases.

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73
Q

A 24-year-old woman presents with sudden onset of intense, localized left lower quadrant pain. She mentions that she recently had a severe episode of coughing followed by the onset of pain. Physical examination shows localized tenderness in the left lower quadrant with guarding. What is the most likely diagnosis?
- A) Ruptured ovarian cyst
- B) Diverticulitis
- C) Splenic rupture
- D) Ectopic pregnancy

A

B) Diverticulitis

Diverticulitis often presents with sudden onset of pain in the left lower quadrant, especially in a younger patient without a clear precipitating factor like trauma. The episode of coughing may have increased intra-abdominal pressure, triggering a diverticular rupture or inflammation.

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74
Q

A 70-year-old male with a history of NSAID use for chronic knee pain presents with melena and dizziness. His hemoglobin is 9.2 g/dL, down from 13.4 g/dL three months ago. Which of the following is the most appropriate initial diagnostic test?
- A) Colonoscopy
- B) Esophagogastroduodenoscopy (EGD)
- C) Abdominal CT scan
- D) Barium enema

A

B) Esophagogastroduodenoscopy (EGD)

EGD is indicated for an elderly patient presenting with melena and a history of NSAID use, as it is the best initial diagnostic test to evaluate for upper gastrointestinal bleeding, likely caused by peptic ulcer disease.

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75
Q

A 55-year-old male presents with severe upper abdominal pain that began after eating a fatty meal. His physical examination shows a positive Murphy’s sign. Which of the following is the most likely cause of his symptoms?
- A) Acute pancreatitis
- B) Acute hepatitis
- C) Acute cholecystitis
- D) Peptic ulcer disease

A

C) Acute cholecystitis

The patient’s symptoms of severe pain after a fatty meal and a positive Murphy’s sign are classic for acute cholecystitis, an inflammation of the gallbladder often caused by gallstones.

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76
Q

A 32-year-old male presents with non-bloody diarrhea and a cramping abdominal pain for two weeks. He recently started a gluten-free diet after a diagnosis of celiac disease but has not seen improvement. Which of the following is the most appropriate next step?
- A) Refer to a dietitian to review dietary compliance
- B) Prescribe a course of antibiotics for presumed bacterial overgrowth
- C) Perform a colonoscopy with biopsy to evaluate for microscopic colitis
- D) Recommend an over-the-counter antidiarrheal

A

A) Refer to a dietitian to review dietary compliance

Before considering further invasive testing or treatments, it is crucial to ensure that the patient is strictly adhering to a gluten-free diet as non-compliance is a common reason for lack of improvement in symptoms of celiac disease.

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77
Q

A 28-year-old female presents to the emergency department with acute epigastric pain, nausea, and vomiting. She has a history of similar episodes, and previous workups including abdominal ultrasound and CT scan were unremarkable. Family history is significant for hyperparathyroidism. What is the most likely diagnosis?
- A) Peptic ulcer disease
- B) Pancreatic cancer
- C) Biliary dyskinesia
- D) Medullary thyroid cancer

A

C) Biliary dyskinesia

Biliary dyskinesia can present with symptoms similar to gallstone disease but without visible stones on imaging studies. It should be considered especially when other common causes have been ruled out and there is a recurrent pattern of symptoms.

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78
Q

A 68-year-old male with a history of atrial fibrillation on warfarin therapy presents with coffee-ground emesis and light-headedness. His vital signs include a BP of 100/60 mmHg, HR 110 bpm, and RR 20/min. Which of the following is the most immediate management step?
- A) Administer intravenous proton pump inhibitors
- B) Perform an urgent upper gastrointestinal endoscopy
- C) Administer intravenous fluids and packed red blood cells
- D) Reverse anticoagulation with vitamin K and fresh frozen plasma

A

C) Administer intravenous fluids and packed red blood cells

The patient presents with signs of an upper gastrointestinal bleed and hemodynamic instability, indicated by coffee-ground emesis and hypotension. Immediate fluid resuscitation with IV fluids and blood transfusion is critical to stabilize the patient before further diagnostic and therapeutic measures.

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79
Q

A 30-year-old female presents with acute abdominal pain, fever, and a rigid abdomen. She has a history of multiple abdominal surgeries. Her last meal was 10 hours ago. Which of the following is the most likely diagnosis?
- A) Acute appendicitis
- B) Bowel obstruction
- C) Gastroenteritis
- D) Cholecystitis

A

B) Bowel obstruction

The presentation of acute abdominal pain, fever, and a rigid abdomen in a patient with a history of multiple abdominal surgeries strongly suggests a bowel obstruction, possibly due to adhesions. The lack of recent food intake is consistent with an obstruction.

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80
Q

A 44-year-old male with a history of alcoholism presents with black, tarry stools and mild abdominal discomfort. Lab results show a low hemoglobin level. Which of the following is the most appropriate initial diagnostic test?
- A) Colonoscopy
- B) Esophagogastroduodenoscopy (EGD)
- C) Abdominal ultrasound
- D) CT scan of the abdomen

A

B) Esophagogastroduodenoscopy (EGD)

The patient’s history of alcoholism and presentation with melena (black, tarry stools) suggest an upper gastrointestinal source of bleeding, most likely related to gastropathy or esophageal varices. EGD is the appropriate initial diagnostic test to visualize the upper gastrointestinal tract.

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81
Q

A 53-year-old woman with no significant medical history presents with right upper quadrant pain, fever, and leukocytosis. Ultrasound shows gallstones and a thickened gallbladder wall. Which of the following is the most appropriate treatment?
- A) Intravenous antibiotics and urgent cholecystectomy
- B) Oral antibiotics and outpatient follow-up
- C) Pain management with NSAIDs
- D) Immediate ERCP

A

A) Intravenous antibiotics and urgent cholecystectomy

This patient’s symptoms and ultrasound findings are indicative of acute cholecystitis. The appropriate management is intravenous antibiotics to cover potential bacterial infection and an urgent cholecystectomy to remove the inflamed gallbladder.

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82
Q

A 40-year-old male presents with diffuse abdominal pain, watery diarrhea, and a recent weight loss of 10 pounds over the past month. He mentions that the symptoms worsen after meals. Which condition is most consistent with this presentation?
- A) Lactose intolerance
- B) Celiac disease
- C) Irritable bowel syndrome (IBS)
- D) Peptic ulcer disease

A

B) Celiac disease

The symptoms of diffuse abdominal pain, diarrhea, and weight loss worsening after meals suggest a malabsorptive disorder like celiac disease, where ingestion of gluten leads to intestinal inflammation and nutrient malabsorption.

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83
Q

A 22-year-old female presents to the emergency department with severe lower abdominal pain. She has a known history of irritable bowel syndrome but states that the pain is different and more severe than usual. On examination, she has a temperature of 38.3°C and rebound tenderness. What is the most likely diagnosis?
- A) Exacerbation of IBS
- B) Acute appendicitis
- C) Pelvic inflammatory disease
- D) Urinary tract infection

A

B) Acute appendicitis

Although the patient has a history of IBS, the presence of fever and rebound tenderness is suggestive of a more acute inflammatory process, such as appendicitis, which requires immediate surgical evaluation.

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84
Q

A 55-year-old male with a history of hypertension and smoking presents with sudden onset of sharp back pain and vomiting. His blood pressure is 180/100 mmHg. Abdominal examination reveals a pulsatile mass. What is the most appropriate initial management?
- A) Immediate surgical consultation
- B) CT scan of the abdomen with contrast
- C) Administration of a beta-blocker
- D) Esophagogastroduodenoscopy (EGD)

A

A) Immediate surgical consultation

The presence of a pulsatile abdominal mass with hypertension and severe pain suggests an abdominal aortic aneurysm (AAA), possibly ruptured. This is a surgical emergency requiring immediate consultation and intervention.

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85
Q

A 47-year-old male with a history of type 2 diabetes presents with nausea, vomiting, and sharp pain radiating to his back. He has a fever and elevated white blood cell count. His lipase is significantly elevated. What is the most likely diagnosis?
- A) Diabetic ketoacidosis
- B) Acute pancreatitis
- C) Myocardial infarction
- D) Cholecystitis

A

B) Acute pancreatitis

The patient’s symptoms of nausea, vomiting, back pain, fever, leukocytosis, and elevated lipase are highly indicative of acute pancreatitis, which can be exacerbated by factors like hyperglycemia in diabetics.

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86
Q

A 26-year-old female presents with acute onset of left-sided abdominal pain and vomiting. She reports using oral contraceptives. Ultrasound reveals a complex mass in the left ovary with free fluid in the pelvis. What is the most likely diagnosis?
- A) Ovarian torsion
- B) Ectopic pregnancy
- C) Ovarian cyst rupture
- D) Pelvic inflammatory disease

A

A) Ovarian torsion

The acute onset of severe, localized pain and ultrasound findings of a complex ovarian mass with free fluid suggest ovarian torsion, a gynecological emergency caused by the rotation of the ovary, potentially compromising blood supply.

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87
Q

A 59-year-old male presents with abdominal pain, jaundice, and clay-colored stools. His past medical history is significant for coronary artery disease and hyperlipidemia. Laboratory tests reveal elevated bilirubin and alkaline phosphatase. What is the most likely diagnosis?
- A) Acute hepatitis
- B) Pancreatic cancer
- C) Choledocholithiasis
- D) Alcoholic liver disease

A

C) Choledocholithiasis

The triad of abdominal pain, jaundice, and pale stools (acholic stools) along with the lab findings suggests an obstruction in the biliary tract, most likely due to stones (choledocholithiasis), commonly seen in patients with a history of gallstones.

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88
Q

A 65-year-old man with a history of smoking presents to the emergency department with acute onset of dyspnea and pleuritic chest pain following a prolonged flight. On examination, his oxygen saturation is 88% on room air, and he appears tachypneic. A D-dimer test is elevated. What is the most appropriate next step in management?**
- A) Administer high-flow oxygen and prepare for intubation.
- B) Start broad-spectrum antibiotics.
- C) Perform a CT pulmonary angiogram.
- D) Initiate nebulized bronchodilator therapy.

A

C) Perform a CT pulmonary angiogram.

The presentation suggests a high probability of pulmonary embolism (PE), given the risk factors (smoking, prolonged flight) and symptoms (dyspnea, pleuritic pain). An elevated D-dimer supports this suspicion. A CT pulmonary angiogram is indicated to confirm diagnosis and guide treatment.

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89
Q

A 28-year-old female with asthma presents to the ED with wheezing and shortness of breath that began after exposure to pollen during a hiking trip. She is using accessory muscles to breathe and her peak expiratory flow is 60% of her predicted normal. What is the most appropriate initial treatment?**
- A) Oral corticosteroids.
- B) Intravenous magnesium sulfate.
- C) High-dose inhaled corticosteroids.
- D) High-dose inhaled bronchodilators.

A

D) High-dose inhaled bronchodilators.

The patient is experiencing an acute asthma exacerbation triggered by allergen exposure. Immediate treatment with high-dose inhaled bronchodilators is indicated to relieve bronchoconstriction. Inhaled corticosteroids and oral corticosteroids may be considered as part of ongoing management, but the initial focus should be on reversing the acute obstruction.

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90
Q

A 72-year-old man with COPD presents with a two-day history of increased sputum production and a change in sputum color from clear to green, accompanied by an increased cough and subjective fever. What is the most likely diagnosis?**
- A) Acute bronchitis.
- B) COPD exacerbation.
- C) Pulmonary embolism.
- D) Lung cancer.

A

B) COPD exacerbation.

This patient’s symptoms are consistent with an acute exacerbation of COPD, characterized by an increase in baseline dyspnea, cough, and/or sputum production. The change in sputum color and presence of fever suggest a possible infectious cause.

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91
Q

A 55-year-old woman with no significant medical history presents to the ED complaining of sudden onset of sharp, left-sided chest pain and shortness of breath after a severe coughing episode. On examination, her breath sounds are diminished on the left side. What is the most likely diagnosis?**
- A) Left-sided pneumothorax.
- B) Acute myocardial infarction.
- C) Pulmonary embolism.
- D) Pneumonia.

A

A) Left-sided pneumothorax.

The sudden onset of sharp, unilateral chest pain and dyspnea following a coughing spell, along with diminished breath sounds on one side, strongly suggests a pneumothorax, likely due to the rupture of a subpleural bleb during coughing.

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92
Q

A 23-year-old man presents to the emergency department with acute onset of fever, dyspnea, and a productive cough with rusty sputum. Physical examination reveals crackles at the right lung base. What is the most appropriate diagnostic test to confirm the suspected diagnosis?**
- A) Chest X-ray.
- B) Complete blood count.
- C) Sputum culture.
- D) Pulmonary function tests.

A

A) Chest X-ray.

The patient’s symptoms and physical findings suggest community-acquired pneumonia, particularly given the description of rusty sputum. A chest X-ray is essential to confirm the presence of an infiltrate indicative of pneumonia.

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93
Q

A 40-year-old female with a history of systemic lupus erythematosus presents with acute onset of hemoptysis and shortness of breath. She is hypoxic with an oxygen saturation of 89% on room air. Which of the following is the most likely underlying cause?**
- A) Bronchitis.
- B) Pulmonary embolism.
- C) Lupus pneumonitis.
- D) Pneumonia.

A

C) Lupus pneumonitis.

Given her history of lupus, the acute presentation with hemoptysis and hypoxia may indicate lupus pneumonitis, an inflammation of the lung tissue associated with systemic lupus erythematosus, though pulmonary embolism should also be considered due to overlapping symptoms.

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94
Q

A 58-year-old man presents with acute onset of right-sided chest pain and shortness of breath. He has a past medical history of hypertension and hyperlipidemia. A chest X-ray shows a large right-sided pleural effusion. What is the most appropriate next step in management?**
- A) Therapeutic thoracentesis.
- B) Administer a diuretic.
- C) Immediate chest tube placement.
- D) Initiate antibiotics.

A

A) Therapeutic thoracentesis.

Therapeutic thoracentesis is indicated to relieve symptoms and to analyze pleural fluid, helping to determine the cause of the effusion (e.g., parapneumonic, malignant, heart failure).

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95
Q

A 50-year-old smoker presents to the ED with sudden onset of confusion, fever, and a productive cough. Chest X-ray reveals right lower lobe consolidation. What is the most likely organism causing this presentation?**
- A) Mycoplasma pneumoniae.
- B) Legionella pneumophila.
- C) Streptococcus pneumoniae.
- D) Haemophilus influenzae.

A

C) Streptococcus pneumoniae.

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia, presenting with symptoms like fever, productive cough, and consolidation on imaging, especially in a smoker.

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96
Q

A 19-year-old college student presents with sudden onset of sharp chest pain and shortness of breath after a minor trauma. On examination, you note subcutaneous emphysema. What is the most likely diagnosis?**
- A) Asthma exacerbation.
- B) Pneumothorax.
- C) Rib fracture.
- D) Pneumomediastinum.

A

D) Pneumomediastinum.

The presence of subcutaneous emphysema, particularly after trauma, suggests pneumomediastinum, where air leaks into the mediastinal area, a condition that can occur independently or alongside a pneumothorax.

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97
Q

A 34-year-old man presents to the ED with worsening dyspnea, low-grade fever, and a dry cough that has persisted for 3 weeks. He recently emigrated from a country with a high prevalence of tuberculosis. What is the most appropriate initial diagnostic test?**
- A) Sputum acid-fast bacilli (AFB) stain.
- B) Tuberculin skin test.
- C) Chest X-ray.
- D) CT scan of the chest.

A

A) Sputum acid-fast bacilli (AFB) stain.

Given the clinical presentation and epidemiological risk factors, testing for tuberculosis with a sputum AFB stain is crucial for rapid identification and confirmation of active tuberculosis, which is necessary to initiate appropriate isolation and treatment.

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98
Q

A 60-year-old smoker is admitted with acute chest pain and a cough productive of bloody sputum. His temperature is 38.5°C, and crackles are heard over the left lung field. A chest X-ray reveals a mass-like opacity in the left upper lobe with surrounding consolidation. What is the most concerning initial diagnosis?**
- A) Acute bronchitis
- B) Lung cancer with obstructive pneumonia
- C) Tuberculosis
- D) Pulmonary abscess

A

B) Lung cancer with obstructive pneumonia

In a smoker with a new mass-like opacity and signs of consolidation on imaging, the primary concern should be lung cancer with post-obstructive pneumonia. This requires immediate further investigation with imaging and likely biopsy to confirm the diagnosis and begin appropriate management.

99
Q

A 44-year-old woman with rheumatoid arthritis, treated with methotrexate, presents with a two-week history of dry cough and progressive shortness of breath. On examination, she has bibasilar crackles. Her oxygen saturation is 92% on room air. What is the most likely diagnosis?**
- A) Heart failure
- B) Pneumonia
- C) Drug-induced pneumonitis
- D) Pulmonary embolism

A

C) Drug-induced pneumonitis

Drug-induced pneumonitis is a potential side effect of methotrexate, particularly in patients with underlying risk factors such as autoimmune diseases. The presentation with a dry cough, progressive dyspnea, and bibasilar crackles supports this diagnosis over more acute conditions such as pneumonia or pulmonary embolism.

100
Q

A 38-year-old male with no significant medical history presents with sudden onset of severe dyspnea, chest pain, and palpitations. He appears anxious and reports recent recreational drug use. Examination reveals tachycardia, tachypnea, and diffuse wheezing. What is the most appropriate initial management?**
- A) Administer intravenous fluids and benzodiazepines.
- B) Perform immediate electrical cardioversion.
- C) Provide supplemental oxygen and initiate bronchodilators.
- D) Start anticoagulation therapy.

A

C) Provide supplemental oxygen and initiate bronchodilators.

The patient’s symptoms suggest acute bronchospasm, possibly triggered by drug use. Initial management should focus on stabilizing the airway and breathing with supplemental oxygen and bronchodilators to relieve wheezing and improve ventilation.

101
Q

A 25-year-old female presents with a two-day history of sharp right-sided chest pain worsening with deep breaths and a low-grade fever. She has a history of oral contraceptive use. Chest X-ray is unremarkable. What is the most likely diagnosis?**
- A) Pleurisy
- B) Pulmonary embolism
- C) Pneumonia
- D) Costochondritis

A

A) Pleurisy

The patient’s symptoms of pleuritic chest pain and low-grade fever, in the context of an unremarkable chest X-ray, suggest pleurisy. Although pulmonary embolism could present similarly, the absence of other risk factors or signs makes primary pleuritic inflammation more likely.

102
Q

A 47-year-old man with a history of IV drug use presents with fever, night sweats, weight loss, and a productive cough with bloody sputum. A chest X-ray shows cavitary lesions in the upper lobes. What is the most appropriate diagnostic test to order next?**
- A) Sputum culture for bacteria
- B) Blood cultures
- C) Sputum acid-fast bacillus stain and culture
- D) CT chest with contrast

A

C) Sputum acid-fast bacillus stain and culture

The patient’s history of IV drug use, systemic symptoms, and cavitary lesions on X-ray are highly suggestive of tuberculosis. The priority is to confirm this with a sputum acid-fast bacillus stain and culture, which are specific for Mycobacterium tuberculosis.

103
Q

A 32-year-old man presents with sudden onset of dyspnea, chest pain, and a sense of apprehension. He mentions a recent long car drive. On examination, he is tachypneic, tachycardic, and hypoxic. What diagnostic test should be performed urgently?**
- A) D-dimer assay
- B) Electrocardiogram
- C) CT pulmonary angiogram
- D) Echocardiography

A

C) CT pulmonary angiogram

The clinical presentation is highly suggestive of a pulmonary embolism, particularly following prolonged immobilization like a long car drive. An urgent CT pulmonary angiogram is indicated to confirm the diagnosis and facilitate immediate management.

104
Q

A 55-year-old female presents with recurrent episodes of dyspnea and a dry cough that worsens at night. She has a history of allergic rhinitis. Physical examination reveals diffuse wheezing. What is the most likely diagnosis?**
- A) Asthma
- B) Chronic bronchitis
- C) Gastroesophageal reflux disease
- D) Heart failure

A

A) Asthma

Given the history of allergic rhinitis and the symptom pattern of night-time worsening, the diagnosis of asthma is most likely. This is supported by physical findings of diffuse wheezing, indicating reversible airway obstruction typical of asthma.

105
Q

A 68-year-old man with chronic heart failure presents with worsening dyspnea, orthopnea, and bilateral lower extremity edema. He is noted to have an S3 gallop on auscultation. Chest X-ray shows cardiomegaly and pulmonary edema. What is the most appropriate immediate treatment?**
- A) High-dose loop diuretics
- B) Broad-spectrum antibiotics
- C) Anticoagulation therapy
- D) Immediate dialysis

A

A) High-dose loop diuretics

The patient’s symptoms and signs suggest acute exacerbation of heart failure. Immediate treatment with high-dose loop diuretics is indicated to reduce fluid overload and pulmonary edema, thereby improving respiratory function and symptoms.

106
Q

A 30-year-old female presents with acute onset of left-sided chest pain and dyspnea. She recently started taking oral contraceptives. Examination shows decreased breath sounds on the left. A chest X-ray reveals a left pneumothorax. What is the most appropriate management for this patient?**
- A) Observation and supplemental oxygen
- B) Needle decompression
- C) Chest tube placement
- D) Immediate surgery

A

C) Chest tube placement

The presence of a pneumothorax in a symptomatic patient typically requires active intervention. Chest tube placement is the appropriate management to re-expand the collapsed lung and prevent recurrence of the pneumothorax.

107
Q

A 49-year-old male, a known case of COPD, presents to the ED with increased shortness of breath, wheezing, and coughing up greenish sputum. His oxygen saturation is 89% on room air. What is the most appropriate initial treatment?**
- A) Administer oral corticosteroids
- B) Start broad-spectrum antibiotics
- C) Initiate inhaled bronchodilators and corticosteroids
- D) Provide noninvasive positive pressure ventilation

A

C) Initiate inhaled bronchodilators and corticosteroids

This presentation is indicative of an acute COPD exacerbation, likely triggered by an infection given the change in sputum color. Initial treatment should include both inhaled bronchodilators to address airway constriction and corticosteroids to reduce inflammation.

108
Q

A 29-year-old woman presents to the emergency department with acute onset of right-sided chest pain that worsens with deep breaths and a feeling of shortness of breath. She has a history of recent surgery 2 weeks ago. On examination, she is tachycardic and tachypneic. What is the most likely diagnosis?**
- A) Myocardial infarction
- B) Pneumonia
- C) Pulmonary embolism
- D) Costochondritis

A

C) Pulmonary embolism

The patient’s history of recent surgery, combined with symptoms of pleuritic chest pain and shortness of breath, raises the suspicion of a pulmonary embolism. The postoperative state increases the risk of venous thromboembolism, making this the most likely diagnosis.

109
Q

A 55-year-old male with a history of smoking presents with cough and a single episode of hemoptysis. Physical examination reveals clubbing and a new wheeze on the left side. What is the most important diagnostic test to perform next?**
- A) Sputum culture
- B) Chest X-ray
- C) Pulmonary function tests
- D) Complete blood count

A

B) Chest X-ray

The presentation of a smoker with new onset wheezing, hemoptysis, and clubbing is concerning for a possible lung cancer. A chest X-ray is an essential first step to evaluate for any mass, consolidation, or other abnormalities that could indicate a malignancy.

110
Q

A 43-year-old female presents with wheezing, cough, and shortness of breath that began after she started taking aspirin for a new diagnosis of migraines. She has no past history of asthma. What is the most likely cause of her symptoms?**
- A) Asthma induced by aspirin
- B) Pulmonary embolism
- C) Acute bronchitis
- D) Allergic reaction to aspirin

A

A) Asthma induced by aspirin

Aspirin-exacerbated respiratory disease (AERD) is likely in this case, where aspirin intake leads to bronchospasm in susceptible individuals. This condition can present similarly to asthma and is triggered by aspirin or other NSAI

111
Q

A 67-year-old man with chronic heart failure presents with worsening dyspnea over the past week. He denies chest pain. His legs are swollen, and crackles are heard halfway up both lung fields. Which intervention is most appropriate to administer first?**
- A) Intravenous furosemide
- B) Oral prednisone
- C) Subcutaneous enoxaparin
- D) High-flow nasal cannula oxygen

A

A) Intravenous furosemide

This patient is showing signs of acute decompensated heart failure with pulmonary edema and peripheral edema. Immediate administration of intravenous furosemide is appropriate to reduce fluid overload and improve respiratory status.

112
Q

A 31-year-old man with a known history of HIV presents with a cough, low-grade fever, and shortness of breath. A chest X-ray shows diffuse interstitial infiltrates. What is the most likely pathogen?**
- A) Streptococcus pneumoniae
- B) Pneumocystis jirovecii
- C) Mycobacterium tuberculosis
- D) Legionella species

A

B) Pneumocystis jirovecii

Pneumocystis jirovecii pneumonia (PCP) is common in patients with HIV, especially those with CD4 counts below 200 cells/μL. The presentation of a dry cough, low-grade fever, and diffuse interstitial infiltrates on X-ray is characteristic of PCP.

112
Q

A 40-year-old man comes to the ED complaining of a severe headache and sudden onset of shortness of breath after a chiropractic neck manipulation. Examination reveals a swollen neck and crepitus on palpation. What is the most likely diagnosis?**
- A) Cervical artery dissection
- B) Pneumothorax
- C) Pneumomediastinum
- D) Esophageal rupture

A

C) Pneumomediastinum

Pneumomediastinum is likely, given the history of neck manipulation followed by acute respiratory symptoms and subcutaneous emphysema. Air escaping into the mediastinal space can occur due to a sudden change in intrathoracic pressure.

113
Q

A 50-year-old woman presents with acute shortness of breath and chest pain. She has a history of rheumatoid arthritis and is currently on immunosuppressive therapy. A chest X-ray shows a large left pleural effusion. What is the next best step in management?**
- A) Start antibiotics for suspected pneumonia.
- B) Perform a diagnostic thoracentesis.
- C) Initiate corticosteroids for rheumatoid flare.
- D) Schedule for urgent pleurodesis.

A

B) Perform a diagnostic thoracentesis.

A diagnostic thoracentesis is necessary to determine the cause of the pleural effusion, particularly in a patient on immunosuppressive therapy where the differential includes infection, rheumatoid effusion, or even malignancy.

114
Q

A 35-year-old female presents with sudden onset of dyspnea and pleuritic chest pain. She is currently on oral contraceptives. An ultrasound of the legs is negative for deep vein thrombosis. What is the most appropriate next step in management?**
- A) Start anticoagulation therapy.
- B) Discharge with NSAIDs for musculoskeletal pain.
- C) Perform a ventilation-perfusion scan.
- D) Repeat ultrasound in 24 hours.

A

C) Perform a ventilation-perfusion scan.

Despite a negative leg ultrasound, her risk factors (including the use of oral contraceptives) and symptoms still warrant further investigation for a pulmonary embolism. A ventilation-perfusion scan is appropriate if a CT pulmonary angiogram is contraindicated or inconclusive.

115
Q

A 22-year-old male presents to the ED with fever, cough, and general malaise. He is a college student living in a dormitory. Auscultation reveals crackles in the right upper lobe. What is the most likely causative agent?**
- A) Mycoplasma pneumoniae
- B) Streptococcus pneumoniae
- C) Haemophilus influenzae
- D) Legionella pneumophila

A

A) Mycoplasma pneumoniae

Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in younger populations such as college students, often presenting with a less acute illness characterized by cough and malaise.

116
Q

A 48-year-old female with a history of smoking and COPD presents to the ED with increased shortness of breath, cough, and change in sputum color to green over the past three days. What is the most appropriate antibiotic to start?**
- A) Amoxicillin
- B) Azithromycin
- C) Ceftriaxone
- D) Vancomycin

A

B) Azithromycin

This patient is likely experiencing an acute exacerbation of COPD with signs of a bacterial infection suggested by the change in sputum color. Azithromycin is effective for typical pathogens involved in COPD exacerbations and has anti-inflammatory properties beneficial in this setting.

117
Q

A 45-year-old man presents with sudden onset severe headache and vomiting. He is conscious but reports a “worst headache of his life.” Physical exam reveals neck stiffness. Which of the following is the most appropriate initial diagnostic study?**
- A. MRI of the brain
- B. CT scan of the head without contrast
- C. Lumbar puncture
- D. Complete blood count (CBC)

A

B. CT scan of the head without contrast

A CT scan of the head without contrast is the initial diagnostic test of choice in patients suspected of having a subarachnoid hemorrhage, which is likely in this patient presenting with sudden severe headache, vomiting, and signs of meningeal irritation.

118
Q

A 23-year-old woman presents with acute loss of consciousness after a head injury during a soccer game. She regained consciousness and complains of headache. Her exam is notable for confusion and right pupil dilation. What is the most likely diagnosis?**
- A. Epidural hematoma
- B. Subdural hematoma
- C. Concussion
- D. Skull fracture

A

A. Epidural hematoma

The presentation of an acute loss of consciousness, followed by a lucid interval, and subsequent neurological deterioration (evidenced by confusion and anisocoria) suggests an epidural hematoma, commonly associated with arterial bleeding, typically from the middle meningeal artery.

119
Q

A 32-year-old woman presents with vertigo, nausea, and unsteady gait. Examination shows horizontal nystagmus. There is no headache or hearing loss. What is the most likely diagnosis?**
- A. Meniere’s disease
- B. Benign paroxysmal positional vertigo (BPPV)
- C. Vestibular neuritis
- D. Brainstem stroke

A

C. Vestibular neuritis

Vestibular neuritis is characterized by acute onset vertigo, nausea, and imbalance with nystagmus, typically without auditory symptoms, distinguishing it from Meniere’s disease and differentiating it from central causes like stroke.

119
Q

A 60-year-old man with history of hypertension presents with sudden onset right-sided weakness and difficulty speaking. CT scan shows no hemorrhage. Which management option is most appropriate within 3 hours of symptom onset?**
- A. Intravenous thrombolysis
- B. Immediate anticoagulation with heparin
- C. Conservative management with observation
- D. Endovascular thrombectomy

A

A. Intravenous thrombolysis

Intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA) is indicated within 4.5 hours of onset in patients with ischemic stroke, provided no contraindications exist and hemorrhage has been ruled out by CT.

120
Q

A 19-year-old college student is brought to the emergency department during final exams, complaining of sudden-onset severe headache, photophobia, and neck stiffness. Temperature is 38.6°C (101.5°F). Which of the following is the most appropriate next step in management?**
- A. Administer broad-spectrum antibiotics and acyclovir
- B. Perform a CT scan of the head
- C. Provide analgesics and reassurance
- D. Perform a lumbar puncture

A

D. Perform a lumbar puncture

This presentation is suggestive of meningitis, potentially bacterial or viral. A lumbar puncture, after excluding increased intracranial pressure with a CT if indicated, is essential for diagnosis and guiding treatment.

121
Q

A 35-year-old woman with no significant medical history presents with sudden onset of left-sided facial droop, slurred speech, and left arm weakness. On examination, her left arm drifts downward when extended. What is the most appropriate initial action?**
- A. Administer aspirin
- B. Obtain a non-contrast CT of the head
- C. Start IV fluids and observe
- D. Administer tissue plasminogen activator (tPA)

A

B. Obtain a non-contrast CT of the head

The immediate priority is to differentiate ischemic from hemorrhagic stroke via a non-contrast CT scan before considering thrombolytic therapy.

122
Q

A 28-year-old man presents with a first-time seizure. He has a fever and a stiff neck. CSF analysis shows elevated white blood cells with a lymphocytic predominance. Which of the following is the most likely diagnosis?**
- A. Bacterial meningitis
- B. Viral encephalitis
- C. Diabetic ketoacidosis
- D. Subarachnoid hemorrhage

A

B. Viral encephalitis

The combination of fever, stiff neck, first-time seizure, and CSF findings of lymphocytic pleocytosis strongly suggests viral encephalitis, possibly herpes simplex virus, which requires prompt antiviral therapy.

123
Q

A 50-year-old man with a history of alcoholism presents with new onset seizures. MRI reveals a mass lesion in the right cerebral hemisphere. What is the most likely diagnosis?**
- A. Meningioma
- B. Glioblastoma multiforme
- C. Metastatic cancer
- D. Brain abscess

A

D. Brain abscess

In a patient with alcoholism presenting with new onset seizures and a mass lesion, a brain abscess is highly probable, particularly if there is an associated infection source or immunocompromised state.

124
Q

A 24-year-old woman presents with numbness, tingling, and weakness in her legs progressing over several days. She has urinary retention and a recent history of a respiratory infection. MRI of the spine shows inflammation. What is the most appropriate initial treatment?**
- A. High-dose corticosteroids
- B. Plasmapheresis
- C. Antiviral therapy
- D. Antibiotics

A

A. High-dose corticosteroids

This presentation is consistent with acute transverse myelitis, likely post-infectious. High-dose corticosteroids are the initial treatment of choice to reduce spinal cord inflammation.

125
Q

A 54-year-old man presents with sudden onset of speech difficulty and right-sided weakness. His symptoms resolved completely within an hour. What is the most likely diagnosis?**
- A. Migraine with aura
- B. Brain tumor
- C. Transient ischemic attack (TIA)
- D. Multiple sclerosis

A

C. Transient ischemic attack (TIA)

This classic description of sudden onset neurological deficits that resolve completely within a short period is indicative of a transient ischemic attack (TIA), a warning sign of potential future cerebrovascular events.

126
Q

A 67-year-old woman presents with sudden vision loss in her left eye described as a curtain coming down over the field of vision, which resolved after a few minutes. She has a history of hypertension and hyperlipidemia. Which of the following is the most likely diagnosis?**
- A. Retinal detachment
- B. Amaurosis fugax
- C. Acute angle-closure glaucoma
- D. Optic neuritis

A

B. Amaurosis fugax

Amaurosis fugax, often caused by a temporary blockage of blood flow to the retina, presents as transient monocular vision loss (“curtain coming down”) and is associated with vascular risk factors like hypertension and hyperlipidemia.

127
Q

A 30-year-old man presents with a new-onset generalized seizure. Postictal phase reveals he has a low-grade fever and was recently treated for a sinus infection. Neurological examination shows no focal deficits. What is the next best step in management?**
- A. Start antiepileptic drug therapy
- B. Immediate lumbar puncture
- C. MRI brain with and without contrast
- D. CT head without contrast

A

C. MRI brain with and without contrast

Given the recent infection and new-onset seizure, an MRI with and without contrast is indicated to evaluate for possible spread of infection to the brain or other structural abnormalities.

128
Q

A 58-year-old man with atrial fibrillation and on anticoagulation therapy presents with acute confusion and fluctuating levels of consciousness. There is no history of recent trauma. CT head shows no hemorrhage. What is the most likely diagnosis?**
- A. Intracerebral hemorrhage
- B. Subdural hematoma
- C. Transient ischemic attack
- D. Hepatic encephalopathy

A

B. Subdural hematoma

Despite no visible hemorrhage on CT, the clinical picture suggests a subdural hematoma, which can have delayed or subtle findings especially in patients on anticoagulation, and might require further imaging like MRI for confirmation.

129
Q

A 22-year-old woman presents to the emergency department with sudden onset of right-sided weakness and difficulty speaking. She has a history of migraines. Examination shows aphasia and right facial droop. What is the most appropriate initial management?**
- A. Administer a migraine abortive medication
- B. Perform a CT angiogram
- C. Administer aspirin immediately
- D. Administer intravenous thrombolysis

A

D. Administer intravenous thrombolysis

Despite her history of migraines, the sudden onset of aphasia and unilateral weakness strongly suggests an ischemic stroke, requiring immediate assessment for intravenous thrombolysis after excluding hemorrhage with CT.

130
Q

A 40-year-old man presents with bilateral tingling in his legs, worsening over two weeks, following a diarrheal illness. He now has difficulty walking. Deep tendon reflexes in the legs are absent. What is the most likely diagnosis?**
- A. Guillain-Barré syndrome
- B. Multiple sclerosis
- C. Peripheral neuropathy
- D. Spinal cord compression

A

A. Guillain-Barré syndrome

Guillain-Barré syndrome, a post-infectious polyneuropathy, presents with ascending weakness and areflexia. The recent diarrheal illness and clinical features support this diagnosis.

131
Q

A 55-year-old man with diabetes presents with sudden sharp pain radiating down his left leg and foot drop. He denies any recent trauma. Examination shows sensory loss on the lateral aspect of the left leg and dorsum of the foot. What is the most likely underlying cause?**
- A. Diabetic neuropathy
- B. Lumbar disc herniation
- C. Spinal stenosis
- D. Peripheral vascular disease

A

B. Lumbar disc herniation

The acute presentation with radicular pain and foot drop, along with sensory loss in a dermatomal pattern, suggests a lumbar disc herniation at the L5 level.

132
Q

A 70-year-old woman with history of hypertension presents with acute left arm weakness and slurred speech that resolved after 20 minutes. Examination is now normal. Which of the following is the most appropriate next step in management?**
- A. Discharge with follow-up in one week
- B. Immediate full-dose anticoagulation
- C. Carotid Doppler ultrasound
- D. Hospital admission for observation and workup

A

D. Hospital admission for observation and workup

Given the transient nature and resolution of symptoms, a transient ischemic attack is suspected. Hospital admission for observation and a comprehensive stroke workup including imaging and possibly carotid Doppler is warranted.

133
Q

An 18-year-old man is brought in by ambulance after being found unresponsive. On examination, he has a Glasgow Coma Scale of 8, pinpoint pupils, and bradycardia. There is a needle track mark on his arm. What is the most likely diagnosis?**
- A. Opioid overdose
- B. Severe head injury
- C. Stroke
- D. Hypoglycemia

A

A. Opioid overdose

The presence of pinpoint pupils, decreased level of consciousness, bradycardia, and evidence of intravenous drug use strongly suggest an opioid overdose.

134
Q

A 25-year-old woman presents with recurrent brief episodes of rapid, rhythmic eye blinking and involuntary movements of the face, which she is unable to suppress. Which of the following is the most likely diagnosis?**
- A. Tourette syndrome
- B. Seizure disorder
- C. Bell’s palsy
- D. Hemifacial spasm

A

A. Tourette syndrome

The description of involuntary, rapid, repetitive movements that the patient cannot suppress fits Tourette syndrome, which often includes both motor and vocal tics.

135
Q

A 48-year-old man with no significant past medical history presents with headache, confusion, and personality change over several days. MRI shows multiple ring-enhancing lesions in the cerebral cortex and basal ganglia. What is the most likely diagnosis?**
- A. Brain abscess
- B. Metastatic cancer
- C. Primary brain tumor
- D. Cerebral toxoplasmosis

A

D. Cerebral toxoplasmosis

In a patient with headache, confusion, personality changes, and ring-enhancing lesions on MRI, cerebral toxoplasmosis should be considered, especially if there is any suggestion of immunocompromise, such as undiagnosed HIV/AIDS.

136
Q

A 28-year-old man presents to the emergency department with a painful red eye since waking up this morning. He reports no history of trauma but mentions that he was diagnosed with type 1 herpes simplex virus a few years ago. Examination reveals a dendritic ulcer on fluorescein staining of the right eye. Which of the following is the most appropriate treatment?
- A) Oral acyclovir
- B) Topical gentamicin
- C) Topical corticosteroids
- D) Topical trifluridine

A

D) Topical trifluridine

Herpes simplex keratitis is typically treated with antiviral therapy. Topical trifluridine is preferred for dendritic ulcers as it inhibits viral replication effectively. Oral acyclovir is used for systemic symptoms, whereas topical corticosteroids are contraindicated due to the risk of exacerbating the infection. Gentamicin is an antibiotic and not effective against viral infections.

137
Q

A 35-year-old construction worker presents with sudden onset of left eye pain and vision loss after a metal fragment struck his eye. On examination, there is a visible foreign body on the cornea and a small hyphema. What is the most important next step in management?
- A) Immediate lateral canthotomy
- B) Elevation of the head and administration of topical beta-blockers
- C) Removal of the foreign body and topical antibiotic therapy
- D) CT scan of the orbit

A

C) Removal of the foreign body and topical antibiotic therapy

Immediate removal of the corneal foreign body and initiation of topical antibiotic therapy are crucial to prevent infection and promote healing. Elevation of the head and beta-blockers are appropriate for managing hyphema, but the immediate concern should be addressing the foreign body. A CT scan is indicated if there is suspicion of intraocular or intraorbital foreign bodies or fractures.

138
Q

A 22-year-old woman complains of bilateral itchy eyes and nasal congestion during spring for the past few years. Examination reveals bilateral conjunctival injection and watery discharge along with pale, boggy nasal mucosa. What is the most likely diagnosis?
- A) Bacterial conjunctivitis
- B) Allergic conjunctivitis
- C) Viral conjunctivitis
- D) Acute sinusitis

A

B) Allergic conjunctivitis

The patient’s symptoms are classic for allergic conjunctivitis, likely related to seasonal allergens. This condition is characterized by bilateral itchy eyes, watery discharge, and conjunctival injection. The presence of nasal congestion and pale, boggy nasal mucosa also suggests a concurrent allergic rhinitis.

139
Q

An 18-year-old male presents with severe sore throat, fever, and difficulty swallowing. His voice is muffled, and he appears to drool. On examination, he has swollen tonsils with uvular deviation. What is the most appropriate next step in management?
- A) Oral antibiotics
- B) Immediate surgical consultation for possible drainage
- C) Throat swab for culture
- D) Trial of antihistamines

A

B) Immediate surgical consultation for possible drainage

The patient’s symptoms suggest a peritonsillar abscess, which is a complication of untreated or partially treated tonsillitis. Features like muffled voice, drooling, and uvular deviation are indicative of a severe infection that may require surgical drainage. This is an emergency as the abscess can obstruct the airway.

140
Q

A 45-year-old female with a history of rheumatoid arthritis presents with a red, painful eye and decreased vision. Slit-lamp examination shows ciliary flush and an irregular pupil. Intraocular pressure is elevated. Which of the following is the most likely diagnosis?
- A) Acute angle-closure glaucoma
- B) Uveitis
- C) Keratitis
- D) Orbital cellulitis

A

A) Acute angle-closure glaucoma

The patient’s symptoms and examination findings of ciliary flush, irregular pupil, and elevated intraocular pressure are indicative of acute angle-closure glaucoma. This condition is an ophthalmic emergency requiring immediate treatment to lower intraocular pressure and prevent permanent vision loss.

141
Q

A 32-year-old man presents to the emergency department complaining of a foreign body sensation in his right eye that started while he was grinding metal without protective goggles. Examination reveals a small corneal abrasion. What is the most appropriate management?
- A) Topical antibiotics and eye patching
- B) Immediate ophthalmologic surgery
- C) Topical antiviral therapy
- D) Systemic antibiotics

A

A) Topical antibiotics and eye patching

Corneal abrasions from metallic foreign bodies require removal of the foreign body, followed by topical antibiotic treatment to prevent infection. Patching the eye can provide comfort and support healing. Surgery is not indicated unless there is significant penetration or retained foreign material.

142
Q

A 60-year-old female presents with sudden onset of right eye pain and blurred vision. On examination, her right pupil is mid-dilated and non-reactive to light. Visual acuity is reduced. Fundoscopy reveals a pale retina with cherry-red spot at the fovea. What is the most likely diagnosis?
- A) Retinal detachment
- B) Acute retinal artery occlusion
- C) Optic neuritis
- D) Vitreous hemorrhage

A

B) Acute retinal artery occlusion

The presentation of sudden pain, blurred vision, a mid-dilated non-reactive pupil, and fundoscopic findings of a pale retina with a cherry-red spot are diagnostic of acute retinal artery occlusion. This is an ophthalmologic emergency that requires immediate intervention to attempt to restore retinal circulation and preserve vision.

143
Q

A 54-year-old man with diabetes presents complaining of “seeing floaters” and flashes of light. Examination shows clear vitreous with debris and a section of the retina appearing elevated from the back of the eye. What is the most appropriate diagnosis?
- A) Diabetic retinopathy
- B) Retinal detachment
- C) Macular degeneration
- D) Glaucoma

A

B) Retinal detachment

the symptoms of seeing floaters and flashes along with the examination finding of a section of the retina being elevated are indicative of retinal detachment. This requires prompt referral to an ophthalmologist for potential surgical repair to prevent permanent vision loss.

144
Q

A 25-year-old woman presents with severe pain and redness in her left eye after improperly removing her contact lens. Examination shows a corneal ulcer. What is the most appropriate initial management?
- A) Topical nonsteroidal anti-inflammatory drugs (NSAIDs)
- B) Topical anesthetic drops
- C) Topical antibiotics
- D) Oral antibiotics

A

C) Topical antibiotics

Corneal ulcers, particularly in contact lens wearers, are typically bacterial in origin and require aggressive treatment with topical antibiotics to prevent progression and preserve vision. NSAIDs and anesthetics are contraindicated as they can delay healing and worsen the outcome.

145
Q

A 70-year-old male presents with sudden, painless loss of vision in one eye. Examination reveals a curtain-like shadow over his field of vision from the top downwards. Which of the following is the most likely diagnosis?
- A) Cataract
- B) Acute glaucoma
- C) Retinal detachment
- D) Macular degeneration

A

C) Retinal detachment

The symptom of a sudden, painless loss of vision with a description of a curtain-like shadow suggests retinal detachment. This condition is an ophthalmological emergency that requires immediate referral for potential surgical intervention.

146
Q

A 62-year-old male presents with sudden onset of severe left flank pain radiating to the groin, accompanied by nausea and visible hematuria. Past medical history includes hyperuricemia and hypertension controlled with hydrochlorothiazide. Which diagnostic study is most appropriate to confirm your suspected diagnosis?**
- A) Renal ultrasound
- B) Non-contrast CT scan of the abdomen and pelvis
- C) Intravenous pyelogram
- D) Urinalysis

A

B) Non-contrast CT scan of the abdomen and pelvis

Non-contrast CT scan of the abdomen and pelvis is the most effective diagnostic tool for detecting nephrolithiasis, which is highly suspected given the patient’s symptoms of flank pain, nausea, and hematuria. This modality provides detailed images of the urinary tract and can detect stones that may not be visible on other studies.

147
Q

A 28-year-old woman presents with acute dysuria, frequency, and suprapubic pain. She has a history of similar symptoms in the past. Physical examination is unremarkable except for mild suprapubic tenderness. What is the most likely diagnosis?**
- A) Acute pyelonephritis
- B) Acute cystitis
- C) Urethral syndrome
- D) Interstitial cystitis

A

B) Acute cystitis

Acute cystitis is diagnosed based on the patient’s symptoms of dysuria, urinary frequency, and suprapubic pain without signs of systemic infection, making it the most likely diagnosis. This is a common urinary tract infection seen in young women.

148
Q

A 75-year-old male with a history of benign prostatic hyperplasia presents with inability to urinate for 8 hours and increasing lower abdominal pain. On examination, his bladder is distended. What is the initial most appropriate intervention?**
- A) Urinary catheterization
- B) Intravenous antibiotics
- C) CT abdomen
- D) Prostate-specific antigen test

A

A) Urinary catheterization

This patient is exhibiting signs of acute urinary retention likely secondary to his known benign prostatic hyperplasia. Immediate bladder decompression via urinary catheterization is necessary to relieve the obstruction and prevent further complications.

149
Q

A 55-year-old female with a history of diabetes mellitus type 2 presents with bilateral lower extremity edema and frothy urine. Her serum albumin level is low. What is the most likely diagnosis?**
- A) Diabetic nephropathy
- B) Acute renal failure
- C) Nephrotic syndrome
- D) Chronic venous insufficiency

A

C) Nephrotic syndrome

Nephrotic syndrome is characterized by heavy proteinuria, hypoalbuminemia, and edema, which align with the patient’s presentation. Diabetes is a common cause of nephrotic syndrome due to diabetic nephropathy.

150
Q

A 23-year-old male presents with fever, dysuria, and back pain. He appears ill and his temperature is 38.9°C. Urinalysis shows pyuria and bacteriuria. Which additional feature on history would most support a diagnosis of pyelonephritis over simple cystitis?**
- A) Recent sexual intercourse
- B) Nocturia
- C) Use of spermicide-coated condoms
- D) Nausea and vomiting

A

D) Nausea and vomiting

Systemic symptoms such as fever, nausea, and vomiting in addition to dysuria and back pain suggest upper urinary tract infection, or pyelonephritis, rather than simple cystitis which typically presents with localized symptoms.

151
Q

A 65-year-old male with a history of hypertension on ACE inhibitors presents with elevated creatinine and potassium levels during routine follow-up. Which of the following is the most appropriate next step in management?**
- A) Increase ACE inhibitor dosage
- B) Discontinue ACE inhibitor
- C) Add a calcium channel blocker
- D) Start insulin and dextrose infusion

A

B) Discontinue ACE inhibitor

ACE inhibitors can cause deterioration in renal function and hyperkalemia, particularly in susceptible individuals. Discontinuing the drug is a prudent step to prevent further renal impairment and manage hyperkalemia.

152
Q

40-year-old female presents with a two-day history of right-sided flank pain and fever. She has a past medical history of recurrent urinary tract infections. Her physical examination reveals costovertebral angle tenderness. What is the most appropriate initial imaging study?**
- A) MRI of the abdomen
- B) Renal ultrasound
- C) Non-contrast CT abdomen
- D) X-ray of the abdomen

A

B) Renal ultrasound

Renal ultrasound is appropriate for evaluating suspected pyelonephritis in this patient, particularly with her history of UTIs and current symptoms indicating a likely kidney infection.

153
Q

A 30-year-old male presents with sudden onset of severe testicular pain for 6 hours, nausea, and vomiting. The testis is elevated and the cremasteric reflex is absent. What is the most likely diagnosis?**
- A) Epididymitis
- B) Testicular torsion
- C) Orchitis
- D) Inguinal hernia

A

B) Testicular torsion

Testicular torsion is a urological emergency characterized by sudden severe testicular pain, absent cremasteric reflex, and nausea. Immediate surgical intervention is required to salvage the testicle.

154
Q

A 54-year-old male with chronic kidney disease presents with generalized weakness and an irregular heartbeat. EKG shows peaked T waves. What is the most likely electrolyte abnormality?**
- A) Hypocalcemia
- B) Hypercalcemia
- C) Hypokalemia
- D) Hyperkalemia

A

D) Hyperkalemia

Peaked T waves on an EKG are indicative of hyperkalemia, which is a common complication in patients with chronic kidney disease due to decreased renal excretion of potassium.

155
Q

A 35-year-old female with no significant past medical history presents with acute onset of right lower quadrant pain, fever, and vomiting. Urinalysis is negative. What is the most likely diagnosis?**
- A) Appendicitis
- B) Cystitis
- C) Nephrolithiasis
- D) Ectopic pregnancy

A

A) Appendicitis

The patient’s symptoms of acute onset right lower quadrant pain, fever, and vomiting, along with a negative urinalysis, most likely point to appendicitis as the diagnosis. An urgent surgical consultation is recommended.

156
Q

A 23-year-old female presents to the emergency department complaining of severe pain in her left eye, sensitivity to light, and blurred vision that started after she was accidentally poked in the eye by her child’s toy. Examination reveals a small corneal abrasion and fluorescein uptake. What is the most appropriate management?
- A) Topical anesthetic and discharge
- B) Patch the eye and prescribe topical antibiotics
- C) Prescribe oral antibiotics
- D) Refer immediately to ophthalmology

A

B) Patch the eye and prescribe topical antibiotics

Corneal abrasions require protection and prevention of infection. Patching the eye can provide pain relief and protect the area, while topical antibiotics prevent bacterial infection. Topical anesthetics are generally avoided as they may delay healing and worsen the injury.

157
Q

A 34-year-old man presents with ear pain, decreased hearing, and a sensation of fullness in the ear. He has a history of frequent swimming. Examination reveals an inflamed external ear canal with a greenish discharge. What is the most likely diagnosis?
- A) Acute otitis media
- B) Otitis externa (swimmer’s ear)
- C) Eustachian tube dysfunction
- D) Cholesteatoma

A

B) Otitis externa (swimmer’s ear)

Otitis externa, commonly known as swimmer’s ear, is characterized by inflammation of the external ear canal, often associated with water exposure. It typically presents with pain, discharge, and a feeling of ear fullness, especially in frequent swimmers.

158
Q

A 48-year-old female presents with sudden onset of right eye pain and redness following a gardening accident where debris flew into her eye. Examination reveals a rust ring and a small foreign body on the cornea. What is the most appropriate initial management?
- A) Refer to ophthalmology for foreign body removal
- B) Attempt removal in the ED with a sterile needle
- C) Prescribe topical antibiotics and discharge
- D) Perform a slit lamp examination and then decide

A

A) Refer to ophthalmology for foreign body removal

Corneal foreign bodies, especially with a rust ring, require careful removal to prevent further damage to the eye. Referral to an ophthalmologist is recommended for proper removal and management to avoid complications such as infection or corneal scarring.

159
Q

A 26-year-old male presents with unilateral nasal congestion, headache, and a purulent nasal discharge that has worsened over the past three days. He also reports a decreased sense of smell. Examination reveals tenderness over the maxillary sinus. What is the most likely diagnosis?
- A) Acute sinusitis
- B) Allergic rhinitis
- C) Nasal polyps
- D) Migraine

A

A) Acute sinusitis

This patient’s symptoms of unilateral nasal congestion, purulent discharge, facial pain, and loss of smell are typical of acute sinusitis. The tenderness over the maxillary sinus further supports this diagnosis.

160
Q

A 59-year-old male with a history of hypertension presents with sudden onset of diplopia and ptosis of the left eyelid. Examination reveals a pupil that is larger on the left than on the right and does not react to light. Which of the following is the most appropriate next step?
- A) MRI of the brain
- B) Prescribe antihypertensive medication
- C) Immediate referral to neurology
- D) Administer topical pilocarpine

A

C) Immediate referral to neurology

These symptoms may indicate an aneurysm impacting the third cranial nerve, particularly given the patient’s history of hypertension. Immediate referral to neurology for further evaluation and possible imaging is critical to rule out life-threatening conditions such as an aneurysm.

161
Q

A 65-year-old female presents with gradual hearing loss, tinnitus, and occasional dizziness over the past year. Examination shows that her tympanic membrane is intact but has lost its translucency. Audiometry confirms conductive hearing loss. What is the most likely diagnosis?
- A) Otosclerosis
- B) Acoustic neuroma
- C) Meniere’s disease
- D) Age-related hearing loss

A

A) Otosclerosis

Otosclerosis often presents with progressive conductive hearing loss, tinnitus, and sometimes dizziness. It involves abnormal bone growth around the stapes, leading to fixation and reduced sound transmission.

162
Q

A 30-year-old male presents with severe right-sided eye pain, photophobia, and blurred vision for two days. He has a history of recurrent corneal erosions. Slit lamp examination shows multiple corneal epithelial defects. What is the most appropriate management?
- A) Topical NSAIDs and discharge
- B) Patch the eye and prescribe topical antibiotics
- C) Refer to ophthalmology for possible corneal transplant
- D) Prescribe oral antibiotics

A

B) Patch the eye and prescribe topical antibiotics

Recurrent corneal erosions can cause acute episodes of eye pain, photophobia, and vision changes. Management typically includes eye patching to relieve pain and prevent eyelid rubbing, along with topical antibiotics to prevent infection.

163
Q

A 27-year-old female presents with a painful, red, swollen area on her upper eyelid. She reports that it has been increasing in size over the past three days. Examination reveals a localized, tender, erythematous swelling on the eyelid with a small central pustule. What is the most likely diagnosis?
- A) Hordeolum (stye)
- B) Chalazion
- C) Preseptal cellulitis
- D) Conjunctivitis

A

A) Hordeolum (stye)

A hordeolum, or stye, is an acute infection of the eyelid glands, presenting as a painful, red, swollen nodule, often with a central pustule. It is usually caused by Staphylococcus aureus.

164
Q

A 21-year-old male presents to the ED with a complaint of something stuck in his throat after eating a large piece of steak. He is drooling and has difficulty swallowing. What is the most appropriate initial management?
- A) Perform a Heimlich maneuver
- B) Attempt to visualize and remove the foreign body with direct laryngoscopy
- C) Administer an antispasmodic to relax the throat muscles
- D) Immediate endoscopic evaluation

A

D) Immediate endoscopic evaluation

This patient is likely suffering from an esophageal foreign body, evidenced by his symptoms of sensation of something stuck, drooling, and dysphagia. Immediate endoscopic evaluation is necessary to locate and potentially remove the foreign body.

165
Q

A 50-year-old male presents with sudden onset of severe vertigo, nausea, and unilateral hearing loss. Examination reveals horizontal nystagmus that worsens when he looks towards the affected ear. What is the most likely diagnosis?
- A) Benign paroxysmal positional vertigo (BPPV)
- B) Vestibular neuritis
- C) Meniere’s disease
- D) Labyrinthitis

A

D) Labyrinthitis

Labyrinthitis is characterized by the acute onset of vertigo, nausea, and hearing loss, accompanied by nystagmus that often worsens with gaze towards the affected side. It involves inflammation of the inner ear or nerves connecting the inner ear to the brain.

166
Q

A 35-year-old male presents with a two-day history of a rapidly expanding, painful rash on his lower leg. He mentions a recent camping trip. On examination, there is a large, sharply demarcated, red area that is hot to touch. He is febrile and reports chills. Which of the following is the most appropriate initial management?

A) Oral antihistamines
B) Intravenous antibiotics
C) Topical steroids
D) Oral acyclovir

A

B) Intravenous antibiotics

The presentation is suggestive of cellulitis, particularly given the rapid expansion, systemic symptoms, and exposure history. Immediate administration of intravenous antibiotics is indicated to combat the likely bacterial infection and prevent systemic spread.

167
Q

A 22-year-old female presents with a three-week history of a painful rash involving her trunk and upper limbs, fever, and malaise. The rash consists of multiple small vesicles on an erythematous base. She has a history of asthma treated with inhaled steroids. What is the most likely diagnosis?

A) Impetigo
B) Herpes zoster
C) Drug eruption
D) Eczema herpeticum

A

D) Eczema herpeticum

Eczema herpeticum is characterized by the eruption of painful vesicles superimposed on areas of atopic dermatitis, often accompanied by fever and malaise, particularly in patients with a history of atopy such as asthma.

168
Q

A 45-year-old male, with no significant medical history, presents with a generalized itchy rash and facial swelling. He reports that symptoms started shortly after taking a new medication prescribed for hypertension. Vital signs are stable. What is the most appropriate next step in management?

A) Discontinue the medication
B) Administer intravenous fluids
C) Perform a skin biopsy
D) Start topical steroids

A

A) Discontinue the medication

The patient’s symptoms are suggestive of an allergic reaction, possibly angioedema, associated with the new medication. Immediate discontinuation of the suspected drug is crucial.

169
Q

A 58-year-old female presents with bilateral lower leg rashes that are hyperpigmented and have a “cobbled” appearance. She has a history of chronic venous insufficiency. What is the most likely diagnosis?

A) Cellulitis
B) Venous stasis dermatitis
C) Dermatitis herpetiformis
D) Psoriasis

A

B) Venous stasis dermatitis

The “cobbled” appearance and hyperpigmentation in a patient with chronic venous insufficiency are characteristic of venous stasis dermatitis.

170
Q

A 30-year-old male presents with a painful ulcer on his genitalia and lymphadenopathy. He is sexually active with multiple partners and rarely uses protection. What is the most likely diagnosis?

A) Herpes simplex
B) Syphilis
C) Chancroid
D) Genital warts

A

C) Chancroid

The presentation of a painful genital ulcer with lymphadenopathy in a sexually active individual suggests chancroid, a sexually transmitted infection caused by Haemophilus ducreyi.

171
Q

A 65-year-old female presents with severe pain in her right ear and a vesicular rash in the ear canal. She reports some hearing loss on the same side. What is the most likely diagnosis?

A) Otitis externa
B) Acute otitis media
C) Ramsay Hunt syndrome
D) Mastoiditis

A

C) Ramsay Hunt syndrome

Ramsay Hunt syndrome involves a reactivation of the varicella-zoster virus, leading to ear pain, vesicles in the auditory canal, and potentially hearing loss due to involvement of the facial nerve.

172
Q

A 50-year-old male presents with a painful, bright red rash on his right shin. He describes it as a sharply defined, raised area that developed over the past 48 hours. He has diabetes and peripheral vascular disease. What is the most likely diagnosis?

A) Cellulitis
B) Necrotizing fasciitis
C) Erysipelas
D) Diabetic ulcer

A

C) Erysipelas

Erysipelas is an acute infection typically caused by Streptococcus and is characterized by a bright red, raised, sharply demarcated rash, commonly on the lower extremities.

173
Q

A 28-year-old male presents with diffuse swelling, redness, and pain over his forearm following a spider bite. He feels feverish and nauseated. What is the initial step in management?

A) Clean the wound and apply a topical antibiotic
B) Administer systemic steroids
C) Start intravenous antibiotics
D) Observe and provide analgesia

A

C) Start intravenous antibiotics

The symptoms suggest a severe reaction to the bite, possibly progressing to cellulitis or a necrotizing infection. Immediate IV antibiotics are needed to treat the infection and prevent further complications.

174
Q

A 40-year-old female presents with sudden onset of multiple small, tense blisters on her abdomen and back, accompanied by severe itching. She has no known drug allergies and has not started any new medications recently. What is the most likely diagnosis?

A) Pemphigus vulgaris
B) Bullous pemphigoid
C) Contact dermatitis
D) Herpes zoster

A

B) Bullous pemphigoid

Bullous pemphigoid typically presents with tense blisters and severe itching, usually in older adults. It is an autoimmune blistering disease.

175
Q

A 27-year-old female presents with a diffuse, blistering rash and mucosal involvement after starting a new antiepileptic drug two weeks ago. She is febrile and appears ill. What is the most likely diagnosis?

A) Allergic contact dermatitis
B) Erythema multiforme
C) Stevens-Johnson syndrome
D) Toxic epidermal necrolysis

A

C) Stevens-Johnson syndrome

Stevens-Johnson syndrome, often triggered by medications, presents with a blistering rash and mucosal involvement and requires immediate medical intervention.

176
Q

A 36-year-old female presents to the emergency department with complaints of sudden onset palpitations, tremors, and heat intolerance over the past three weeks. She has lost weight despite an increased appetite. On examination, she has a palpable thyroid gland, tachycardia, and mild exophthalmos. Which of the following is the most likely diagnosis?**
- A) Adrenal insufficiency
- B) Hyperthyroidism
- C) Nonketotic hyperglycemia
- D) Cushing disease

A

B) Hyperthyroidism

The patient’s symptoms of palpitations, tremors, heat intolerance, weight loss despite increased appetite, and physical findings of a palpable thyroid gland, tachycardia, and exophthalmos are characteristic of hyperthyroidism. These symptoms are consistent with an overactive thyroid, which can be confirmed with further thyroid function tests.

177
Q

A 59-year-old man with a history of type 2 diabetes presents with confusion, abdominal pain, and vomiting. He has a fruity odor on his breath. His initial laboratory results show a high anion gap metabolic acidosis and elevated blood ketones. What is the most appropriate initial treatment?**
- A) Oral rehydration
- B) Intravenous insulin
- C) Broad-spectrum antibiotics
- D) Immediate dialysis

A

B) Intravenous insulin

This patient is presenting with diabetic ketoacidosis (DKA), evident from high anion gap metabolic acidosis, elevated blood ketones, and clinical symptoms. The first line of treatment for DKA is intravenous insulin to reduce blood glucose levels and correct ketosis.

178
Q

A 23-year-old woman arrives at the emergency department with generalized weakness and severe fatigue that has worsened over the past month. She also reports nausea and a recent onset of skin hyperpigmentation. Blood tests reveal hyponatremia and hyperkalemia. Which condition should be considered in the differential diagnosis?**
- A) Hyperthyroidism
- B) Adrenal insufficiency
- C) Diabetic ketoacidosis
- D) Acute pancreatitis

A

B) Adrenal insufficiency

The patient’s symptoms of generalized weakness, severe fatigue, nausea, skin hyperpigmentation, hyponatremia, and hyperkalemia are suggestive of adrenal insufficiency, where there is a deficiency in the production of adrenal hormones, particularly cortisol.

179
Q

An emergency department receives a 45-year-old male with a past medical history of hypertension. He presents with new-onset confusion and a severe headache. His family notes that he has been increasingly thirsty and urinating more than usual over the past week. Initial labs show serum sodium of 158 mEq/L. What is the most likely diagnosis?**
- A) Cerebral hemorrhage
- B) Acute hypertensive crisis
- C) Diabetes insipidus
- D) Nonketotic hyperglycemia

A

C) Diabetes insipidus

The patient’s symptoms of increased thirst, polyuria, and notably high serum sodium suggest diabetes insipidus, a condition characterized by insufficient production of antidiuretic hormone (ADH) leading to dilute urine and hypernatremia.

180
Q

A 28-year-old female with no significant past medical history presents with tremors, weight loss, and palpitations. On examination, you notice a fine tremor in her hands. Her thyroid function tests show decreased TSH and elevated free T4. What is the next best step in management for this patient?**
- A) Administer a beta-blocker
- B) Start corticosteroids
- C) Perform a thyroidectomy
- D) Prescribe an antithyroid medication

A

D) Prescribe an antithyroid medication

The clinical presentation and lab findings indicate hyperthyroidism. The initial management involves antithyroid medications to reduce thyroid hormone production and mitigate symptoms.

181
Q

A 55-year-old woman with type 1 diabetes presents to the ER with abdominal pain and altered mental status. Her family mentions that she has been unwell and not managing her diabetes properly. Her blood glucose is 620 mg/dL, and her labs show high blood ketones without significant acidosis. What is the most appropriate diagnosis?**
- A) Diabetic ketoacidosis
- B) Hyperosmolar hyperglycemic state
- C) Acute pancreatitis
- D) Cushing disease

A

B) Hyperosmolar hyperglycemic state

This patient, with type 1 diabetes, elevated blood glucose, high blood ketones, and without significant acidosis, is more likely experiencing a hyperosmolar hyperglycemic state (HHS), which is characterized by severe hyperglycemia and dehydration, more common in type 2 diabetics but can occur in type 1.

182
Q

A 32-year-old male presents with fatigue, increased sensitivity to cold, and constipation. His TSH is elevated, and free T4 is low on screening. What is the most likely cause of his symptoms?**
- A) Hyperthyroidism
- B) Hypothyroidism
- C) Adrenal insufficiency
- D) Diabetic ketoacidosis

A

B) Hypothyroidism

he symptoms of fatigue, cold sensitivity, constipation, along with the lab findings of elevated TSH and low free T4, are indicative of hypothyroidism, where there is insufficient production of thyroid hormones.

183
Q

A 65-year-old male with a history of prostate cancer is brought to the emergency department with confusion and lethargy. His serum calcium is noted to be 13.5 mg/dL. What is the most likely diagnosis?**
- A) Hyperparathyroidism
- B) Hypocalcemia
- C) Hypercalcemia of malignancy
- D) Vitamin D toxicity

A

C) Hypercalcemia of malignancy

In a patient with prostate cancer, the finding of a high serum calcium level is most likely due to hypercalcemia of malignancy, a common paraneoplastic syndrome associated with cancer.

184
Q

A 40-year-old female with a known history of thyroidectomy presents with tingling around her lips and in her fingertips, and reports episodes of muscle cramps. On examination, she exhibits a positive Chvostek’s sign. What is the likely cause of her symptoms?**
- A) Hyperglycemia
- B) Hypocalcemia
- C) Hyperkalemia
- D) Hypomagnesemia

A

B) Hypocalcemia

Following thyroidectomy, this patient likely has hypoparathyroidism leading to hypocalcemia, as indicated by symptoms of tingling, muscle cramps, and a positive Chvostek’s sign.

185
Q

A 38-year-old male with a history of alcohol abuse presents with confusion, polyuria, and dehydration. His lab tests reveal high serum sodium and normal glucose levels. An MRI shows a mass in the hypothalamic region. What is the most probable diagnosis?**
- A) Diabetes mellitus
- B) Cushing’s disease
- C) Diabetes insipidus
- D) Nonketotic hyperglycemia

A

C) Diabetes insipidus

The symptoms of polyuria, dehydration, and a hypothalamic mass, along with high serum sodium and normal glucose levels, suggest diabetes insipidus, likely central, due to damage or dysfunction in the hypothalamus.

186
Q

A 24-year-old woman, 32 weeks pregnant, presents to the emergency department with a one-hour history of vaginal bleeding and mild abdominal pain. Her pregnancy has been uncomplicated until now, and her prenatal screenings were normal. On examination, her vitals are stable, and the ultrasound shows a normally positioned fetus with a heart rate of 140 bpm. There is evidence of a placental abruption. Which of the following is the most appropriate next step in management?**
- A. Immediate cesarean delivery
- B. Therapeutic bed rest in hospital
- C. Administration of IV fluids and corticosteroids
- D. Discharge with outpatient follow-up

A

C. Administration of IV fluids and corticosteroids

In the setting of a stable mother and fetus, the immediate management should include stabilization with IV fluids to ensure maternal and fetal well-being and administration of corticosteroids to accelerate fetal lung maturity in case of premature delivery. Immediate cesarean delivery (A) is reserved for cases where the fetus or mother is unstable. Therapeutic bed rest (B) and discharge (D) are inappropriate due to the risks associated with placental abruption.

187
Q

A 29-year-old woman presents with sudden onset of right lower quadrant pain and syncope. She mentions that she might be pregnant but is not sure. Her BP is 90/60 mmHg, heart rate is 110 bpm, and she appears pale. A urine pregnancy test confirms pregnancy. Which of the following is the most likely diagnosis?**
- A. Appendicitis
- B. Ectopic pregnancy
- C. Ovarian torsion
- D. Urinary tract infection

A

B. Ectopic pregnancy

The presentation of hypotension, tachycardia, and positive pregnancy test strongly suggests an ectopic pregnancy leading to internal bleeding, which is a surgical emergency. Appendicitis (A) and ovarian torsion (C) are possible but less likely given the pregnancy and syncope, typically not features of these conditions initially.

188
Q

A 35-year-old woman, 38 weeks pregnant, presents complaining of a sudden gush of clear fluid followed by strong contractions every 5 minutes. There is no vaginal bleeding, and fetal movements are normal. What is the most likely stage of labor she is experiencing?**
- A. Latent phase of the first stage
- B. Active phase of the first stage
- C. Second stage of labor
- D. Third stage of labor

A

B. Active phase of the first stage

The active phase of the first stage of labor is characterized by strong, frequent contractions and significant cervical dilation progress. The sudden gush of fluid suggests rupture of membranes, indicating that labor has progressed beyond the latent phase.

189
Q

A 22-year-old woman presents with severe pelvic pain, fever, and vaginal discharge. Her temperature is 38.6°C, and pelvic examination reveals cervical motion tenderness and a purulent cervical discharge. Which of the following is the most appropriate initial antibiotic therapy?**
- A. Azithromycin and doxycycline
- B. Metronidazole and levofloxacin
- C. Ceftriaxone and doxycycline
- D. Clindamycin and gentamicin

A

C. Ceftriaxone and doxycycline

Ceftriaxone and doxycycline are the recommended initial therapy for pelvic inflammatory disease, which this patient most likely has based on her symptoms and examination findings.

190
Q

A 27-year-old woman presents with acute onset of left lower quadrant pain and vaginal bleeding. She is hypotensive and tachycardic. A bedside ultrasound reveals a complex adnexal mass. Given the suspected diagnosis of a ruptured ectopic pregnancy, which of the following is the most appropriate management?**
- A. Urgent laparoscopy
- B. Methotrexate administration
- C. Blood transfusion and stabilization
- D. Both A and C are correct

A

D. Both A and C are correct

This patient requires immediate stabilization with blood transfusion due to suspected internal bleeding and an urgent laparoscopy to address the source of bleeding and manage the ectopic pregnancy.

191
Q

A 19-year-old woman presents with severe cramping and heavy vaginal bleeding. She is pale, diaphoretic, and her blood pressure is 85/55 mmHg. The most likely diagnosis is a spontaneous abortion. What is the initial step in managing this patient?**
- A. Immediate dilation and curettage
- B. Blood transfusion and IV fluids
- C. Administration of misoprostol
- D. Outpatient follow-up in 24 hours

A

B. Blood transfusion and IV fluids

The primary concern is the patient’s hemodynamic instability, likely due to significant blood loss. Immediate resuscitation with IV fluids and blood transfusion is necessary before any further gynecological intervention.

192
Q

A 31-year-old woman, 26 weeks pregnant, presents with a headache, blurred vision, and right upper quadrant pain. Her blood pressure is 160/110 mmHg. Urinalysis shows proteinuria. Which of the following is the most appropriate diagnosis?**
- A. Preeclampsia
- B. Eclampsia
- C. Gestational hypertension
- D. Chronic hypertension

A

A. Preeclampsia

The presence of hypertension, proteinuria, and symptoms such as headache and blurred vision in a pregnant woman are diagnostic of preeclampsia. Eclampsia (B) involves seizures, which have not occurred yet.

193
Q

A 24-year-old woman, not known to be pregnant, presents with sudden pelvic pain and syncope. Her blood pressure is 90/50 mmHg, and heart rate is 120 bpm. A positive pregnancy test and an ultrasound showing an empty uterus but evidence of abdominal free fluid suggest which of the following?**
- A. Threatened abortion
- B. Ruptured ovarian cyst
- C. Ectopic pregnancy
- D. Acute appendicitis

A

C. Ectopic pregnancy

The combination of a positive pregnancy test, hypotension, and free fluid in the abdomen in the absence of an intrauterine pregnancy is highly suggestive of a ruptured ectopic pregnancy, requiring immediate surgical intervention.

194
Q

A 28-year-old woman, 35 weeks pregnant, presents with sudden onset of severe abdominal pain, vaginal bleeding, and fetal distress noted on the monitor. The most likely diagnosis is placental abruption. What is the most immediate management for this condition?**
- A. Immediate cesarean delivery
- B. Magnesium sulfate infusion
- C. Betamethasone for fetal lung maturity
- D. Therapeutic bed rest

A

A. Immediate cesarean delivery

Placental abruption with signs of fetal distress requires immediate delivery, typically by cesarean section, to prevent further morbidity or mortality to the mother and fetus.

195
Q

A 30-year-old woman presents with acute pelvic pain, nausea, and vomiting. She reports her last menstrual period was two months ago but has not taken a pregnancy test. Physical examination shows cervical motion tenderness and a palpable adnexal mass. What is the most likely diagnosis?**
- A. Ovarian torsion
- B. Appendicitis
- C. Ectopic pregnancy
- D. Pelvic inflammatory disease

A

A. Ovarian torsion

Given the acute presentation with pelvic pain, nausea, and an adnexal mass, ovarian torsion is the most likely diagnosis. This condition requires immediate surgical intervention to prevent further complications such as ovarian necrosis.

196
Q

A 68-year-old man with a history of hypertension and hyperlipidemia presents to the emergency department with sudden onset of severe chest pain radiating to his left arm, beginning 30 minutes ago while resting. He appears pale and diaphoretic. His blood pressure is 160/90 mmHg, heart rate 110 bpm, and respiratory rate 22 breaths per minute. An ECG shows ST elevation in leads II, III, and aVF. Which of the following is the most appropriate next step in management?**

  • A. Administer sublingual nitroglycerin
  • B. Perform immediate coronary angiography
  • C. Give aspirin and clopidogrel
  • D. Obtain a chest X-ray
A
  • B. Perform immediate coronary angiography

The patient’s symptoms and ECG findings are indicative of an ST-segment elevation myocardial infarction (STEMI), specifically involving the inferior wall given the leads affected. Immediate coronary angiography is crucial as it is part of revascularization therapy, which is the recommended treatment for STEMI patients to restore blood flow and minimize myocardial damage.

197
Q

A 55-year-old woman presents with shortness of breath and palpitations. She has a history of type 2 diabetes and atrial fibrillation. Her blood pressure is 140/85 mmHg, heart rate is irregularly irregular at 120 bpm, and her lungs are clear. ECG confirms atrial fibrillation with rapid ventricular response. What is the most appropriate initial treatment?**

  • A. Metoprolol
  • B. Amiodarone
  • C. Digoxin
  • D. Warfarin
A
  • A. Metoprolol

Metoprolol is indicated as it helps in controlling the heart rate by slowing the AV nodal conduction, which is beneficial in atrial fibrillation with rapid ventricular response. This beta-blocker is effective in reducing symptoms and stabilizing the patient’s condition.

198
Q

A 72-year-old man with a history of chronic heart failure is brought to the ER with worsening dyspnea and ankle swelling. Physical examination reveals jugular venous distention, pulmonary rales, and peripheral edema. Chest X-ray shows cardiomegaly and pulmonary congestion. What is the most appropriate initial management?**

  • A. Start IV furosemide
  • B. Perform endotracheal intubation
  • C. Administer subcutaneous enoxaparin
  • D. Give oral prednisone
A

A. Start IV furosemide

IV furosemide is appropriate for acute decompensated heart failure with signs of fluid overload as evidenced by dyspnea, rales, and peripheral edema. It provides rapid diuresis, reducing fluid congestion and improving symptoms.

199
Q

A 63-year-old female presents with dizziness and a fainting spell while gardening. She reports no previous cardiac history but has a mild headache. Her pulse is 45 bpm, and blood pressure is 110/70 mmHg. ECG shows a regular, slow rhythm with absent P waves and wide QRS complexes. What is the likely diagnosis?**

  • A. Second-degree AV block
  • B. Sinus bradycardia
  • C. Third-degree AV block
  • D. Ventricular tachycardia
A

C. Third-degree AV block

The ECG findings and clinical presentation suggest a third-degree AV block (complete heart block), where there is no association between P waves and QRS complexes. This condition often requires urgent pacing.

200
Q

58-year-old man presents to the emergency department complaining of sudden, severe back pain and a syncopal episode. His blood pressure is 90/60 mmHg, and he has a pulsatile abdominal mass. His extremities are cool and pale. Which of the following is the most likely diagnosis?**

  • A. Acute pancreatitis
  • B. Ruptured aortic aneurysm
  • C. Myocardial infarction
  • D. Pulmonary embolism
A

B. Ruptured aortic aneurysm

The presence of a pulsatile abdominal mass, hypotension, and the described symptoms are highly suggestive of a ruptured aortic aneurysm, which is a surgical emergency. Immediate imaging and surgical consultation are required.

201
Q

A 50-year-old man with known peripheral arterial disease presents with sudden onset of cold, painful right leg. The leg appears pale and pulseless. What is the most likely diagnosis, and what is the immediate management step?**

  • A. Deep vein thrombosis, start anticoagulation
  • B. Acute arterial occlusion, immediate surgical evaluation
  • C. Chronic venous insufficiency, prescribe compression stockings
  • D. Cellulitis, administer IV antibiotics
A

B. Acute arterial occlusion, immediate surgical evaluation

Acute arterial occlusion presents with the ‘five Ps’: Pain, Pallor, Pulselessness, Paresthesia, and Paralysis. Immediate surgical evaluation is crucial for possible revascularization to save the limb.

202
Q

A 45-year-old man presents with crushing chest pain, nausea, and sweating. His ECG shows ST elevations in the anterior leads. His troponin I level returned elevated. Which of the following medications should be administered first?**

  • A. Oral aspirin
  • B. IV metoprolol
  • C. Sublingual nitroglycerin
  • D. Oral atorvastatin
A
  • A. Oral aspirin

Aspirin is given immediately in cases of suspected myocardial infarction to reduce cardiac event-related mortality by inhibiting platelet aggregation, thus preventing further thrombus formation.

203
Q

A 70-year-old woman with no significant medical history suddenly collapses while shopping. Bystanders report she was complaining of severe chest pain before collapsing. On arrival, she is pulseless and CPR is initiated. The monitor shows ventricular fibrillation. What is the immediate next step?**

  • A. Administer IV amiodarone
  • B. Perform defibrillation
  • C. Insert an oropharyngeal airway
  • D. Administer IV epinephrine
A

B. Perform defibrillation

Immediate defibrillation is the most effective treatment for ventricular fibrillation, especially in the context of cardiac arrest following a suspected myocardial infarction.

204
Q

A 60-year-old woman with a history of rheumatic heart disease presents with acute shortness of breath, orthopnea, and paroxysmal nocturnal dyspnea. Her ECG shows atrial fibrillation with rapid ventricular rate. What is the most likely exacerbating factor for her symptoms?**

  • A. Chronic obstructive pulmonary disease
  • B. Acute decompensated heart failure
  • C. Acute renal failure
  • D. Thyroid storm
A

B. Acute decompensated heart failure

Given the history of rheumatic heart disease, her symptoms are indicative of acute decompensated heart failure, likely exacerbated by the onset of atrial fibrillation with rapid ventricular rate, which compromises cardiac efficiency.

205
Q

A 54-year-old male with a history of smoking and hypertension presents with sudden onset of tearing chest pain radiating to his back. His blood pressure is 180/120 mmHg. A chest X-ray shows a widened mediastinum. What is the most appropriate diagnostic test to confirm the suspected diagnosis?**

- A. Transthoracic echocardiogram

- B. CT scan of the chest with contrast

- C. MRI of the chest

- D. Coronary angiography
A

B. CT scan of the chest with contrast

The clinical presentation is suggestive of an aortic dissection. A CT scan of the chest with contrast is the diagnostic test of choice for confirming the presence of an aortic dissection, as it provides detailed images of the aorta and can identify the extent of the dissection.

206
Q

A 65-year-old male with a history of congestive heart failure and diabetes mellitus presents with progressive shortness of breath, fatigue, and a weight gain of 5 kg over the past week. Physical examination reveals rales halfway up both lung fields, jugular venous distention, and 3+ pitting edema of the lower extremities. Which therapeutic intervention is most appropriate to administer first?**

  • A. Oral furosemide
  • B. Intravenous furosemide
  • C. Intravenous nitroglycerin
  • D. Oxygen therapy
A

B. Intravenous furosemide

The patient presents with acute decompensated heart failure with signs of significant volume overload. Intravenous furosemide is indicated for rapid diuresis to relieve symptoms of fluid congestion and improve respiratory status.

207
Q

A 39-year-old woman with no significant medical history presents with palpitations and light-headedness. Her pulse is 160 bpm, and ECG shows a narrow complex tachycardia without visible P waves. Vagal maneuvers have been attempted without success. What is the most appropriate pharmacologic treatment?**

  • A. IV adenosine
  • B. Oral beta-blockers
  • C. IV amiodarone
  • D. Oral digoxin
A

A. IV adenosine

The patient likely has supraventricular tachycardia (SVT). IV adenosine is the drug of choice for rapid termination of SVT due to its ability to transiently block the AV node.

208
Q

A 58-year-old male with a history of chronic smoking and chronic obstructive pulmonary disease presents with acute onset of severe chest pain and dyspnea. Examination reveals a hypotensive patient with a loud diastolic murmur best heard over the right sternal border. Which of the following is the most likely diagnosis?**

  • A. Acute myocardial infarction
  • B. Aortic dissection
  • C. Acute pulmonary embolism
  • D. Aortic regurgitation
A

B. Aortic dissection

The combination of severe chest pain, hypotension, and a diastolic murmur suggests an aortic dissection, which may involve the aortic valve leading to acute aortic regurgitation as a complication.

209
Q

A 70-year-old female with a history of atrial fibrillation is brought in by ambulance after being found unconscious at home. On examination, she is hypotensive and bradycardic. ECG shows a wide complex bradycardia with no discernible P waves. What is the most appropriate initial management?**

  • A. Administer IV atropine
  • B. Immediate electrical cardioversion
  • C. Placement of a transcutaneous pacemaker
  • D. Administer IV dopamine
A

C. Placement of a transcutaneous pacemaker

The patient presents with symptomatic bradycardia likely due to high-grade AV block or ventricular escape rhythm. The placement of a transcutaneous pacemaker is indicated to provide stable cardiac output until a more permanent solution is implemented.

210
Q

A 55-year-old male is brought to the ER with chest pain and diaphoresis that started while mowing the lawn. His past medical history is significant for hypercholesterolemia. ECG shows ST elevations in leads V2-V4. Which enzyme is most specific for diagnosing an acute myocardial infarction in this setting?**

  • A. Creatine kinase-MB
  • B. Troponin I
  • C. Aspartate transaminase (AST)
  • D. Lactate dehydrogenase (LDH)
A

B. Troponin I

Troponin I is the most specific and sensitive marker for myocardial injury and is essential for the diagnosis of myocardial infarction, especially in patients presenting with classic symptoms and ECG changes.

211
Q

A 48-year-old woman presents with sudden onset of shortness of breath and right-sided chest pain following a long airplane flight. She is tachycardic and hypoxic. A D-dimer test is markedly elevated. What is the most appropriate next step in management?**

  • A. Immediate administration of therapeutic anticoagulation
  • B. Perform a ventilation-perfusion (V/Q) scan
  • C. Obtain a spiral CT scan of the chest
  • D. Administer supplemental oxygen and observe
A

C. Obtain a spiral CT scan of the chest

The clinical presentation is suggestive of a pulmonary embolism. A spiral CT scan of the chest is the most appropriate diagnostic test to confirm the diagnosis and guide further management, especially in a hemodynamically stable patient.

212
Q

A 62-year-old male with a known history of aortic stenosis presents complaining of dizziness and syncope. Examination reveals a systolic ejection murmur best heard at the right second intercostal space. Which of the following is the most appropriate diagnostic test to assess the severity of his condition?**

  • A. Transthoracic echocardiogram
  • B. Cardiac catheterization
  • C. Holter monitor
  • D. Exercise stress test
A

A. Transthoracic echocardiogram

A transthoracic echocardiogram is the best initial test to assess the severity of aortic stenosis, evaluate valve anatomy, and measure hemodynamic parameters such as gradient and valve area.

213
Q

A 50-year-old male with a history of hypertension presents with acute tearing pain radiating to his back and a blood pressure discrepancy between arms. What is the most likely diagnosis and the best initial imaging study to confirm it?**

  • A. Acute myocardial infarction, echocardiogram
  • B. Aortic dissection, CT angiography
  • C. Pulmonary embolism, V/Q scan
  • D. Pericarditis, ECG
A

B. Aortic dissection, CT angiography

The symptoms suggest an aortic dissection. A CT angiography is the most appropriate imaging study to confirm the diagnosis as it provides detailed images of the aorta and can show the presence of a dissection flap and involvement of branch vessels.

214
Q

A 44-year-old female presents to the emergency department with severe chest pain and a history of systolic heart failure. ECG shows no new changes. BNP levels are elevated. Which of the following is the most likely cause of her chest pain?**

  • A. Acute myocardial infarction
  • B. Acute coronary syndrome
  • C. Acute exacerbation of heart failure
  • D. Pulmonary embolism
A

C. Acute exacerbation of heart failure

In patients with systolic heart failure presenting with chest pain and elevated BNP, acute exacerbation of heart failure should be considered as a probable cause, especially in the absence of new ECG changes.

215
Q

A 68-year-old male with a history of diabetes and smoking presents with sudden onset of severe abdominal pain and back pain. His blood pressure is 180/110 mmHg. Examination reveals a pulsatile abdominal mass. What is the most likely diagnosis and the immediate step to take?**

- A. Acute pancreatitis, administer IV fluids

- B. Abdominal aortic aneurysm, urgent surgical referral

- C. Diverticulitis, administer antibiotics

- D. Kidney stones, perform a CT scan
A

B. Abdominal aortic aneurysm, urgent surgical referral

the presence of a pulsatile abdominal mass in a patient with risk factors such as diabetes and smoking, accompanied by severe pain and high blood pressure, strongly suggests an abdominal aortic aneurysm. Urgent surgical referral is necessary as this condition can lead to rupture, which is life-threatening.

216
Q

A 54-year-old female with a past medical history of rheumatoid arthritis and no known cardiac history presents with new onset chest pain. She describes the pain as sharp and worsening with inspiration. She also reports a recent upper respiratory tract infection. Physical examination shows a friction rub. Which of the following is the most likely diagnosis?**

  • A. Acute pericarditis
  • B. Myocardial infarction
  • C. Pulmonary embolism
  • D. Costochondritis
A

A. Acute pericarditis

he clinical presentation of sharp pain worsening with inspiration and the presence of a pericardial friction rub strongly suggest acute pericarditis, likely precipitated by a recent viral infection.

217
Q

A 67-year-old man presents with sudden onset of palpitations and light-headedness. His pulse is 200 bpm, and blood pressure is 110/70 mmHg. ECG shows a regular tachycardia with narrow QRS complexes. Vagal maneuvers are ineffective. What is the next best step in management?**

  • A. Administer IV adenosine
  • B. Immediate electrical cardioversion
  • C. Administer oral beta-blockers
  • D. Perform carotid sinus massage
A

A. Administer IV adenosine

the presence of a stable, narrow complex tachycardia unresponsive to vagal maneuvers suggests SVT. IV adenosine is effective for terminating SVT by temporarily blocking the AV node.

218
Q

A 59-year-old male with a history of diabetes and hypertension presents to the emergency department complaining of sudden, severe left-sided chest pain radiating to the back. His blood pressure is 200/120 mmHg in the right arm and 180/110 mmHg in the left arm. A diastolic murmur is heard on auscultation. Which diagnostic test should be performed immediately?**

  • A. Transthoracic echocardiogram
  • B. CT angiography of the chest
  • C. Coronary angiography
  • D. X-ray of the chest
A

B. CT angiography of the chest

The symptoms of severe chest pain radiating to the back, differential blood pressure readings between arms, and a diastolic murmur suggest aortic dissection. A CT angiography of the chest is crucial for immediate diagnosis.

219
Q

A 72-year-old woman presents to the ED with fatigue and an irregular heartbeat. She has a history of heart failure. Her ECG shows atrial fibrillation with a rapid ventricular response. Her blood pressure is 100/60 mmHg. Which of the following is the best initial treatment?**

  • A. IV digoxin
  • B. IV diltiazem
  • C. Oral amiodarone
  • D. IV metoprolol
A

B. IV diltiazem

Given her history of heart failure and presentation with atrial fibrillation with rapid ventricular response, IV diltiazem is appropriate for rate control. It helps decrease the ventricular rate without adversely affecting cardiac output.

220
Q

A 45-year-old man with a history of hyperlipidemia presents with sudden onset of shortness of breath, right-sided chest pain, and hemoptysis. He recently returned from a long car trip. His oxygen saturation is 89% on room air. What is the most appropriate diagnostic test to confirm the suspected condition?**

  • A. Chest X-ray
  • B. D-dimer assay
  • C. CT pulmonary angiography
  • D. Echocardiogram
A

C. CT pulmonary angiography

The clinical scenario is highly suggestive of a pulmonary embolism. CT pulmonary angiography is the gold standard for diagnosing pulmonary embolism and should be performed immediately given the symptoms.

221
Q

A 63-year-old female with a history of mitral valve prolapse presents to the emergency department with palpitations and a feeling of ‘heart flipping in her chest’. Her ECG shows occasional premature ventricular contractions (PVCs). What is the most appropriate management for this patient?**

  • A. Immediate electrical cardioversion
  • B. Administer IV beta-blockers
  • C. Observation and reassurance
  • D. Insert an implantable cardioverter-defibrillator
A

C. Observation and reassurance

In a patient with mitral valve prolapse who is experiencing occasional PVCs but no other signs of hemodynamic instability, the most appropriate management is observation and reassurance. PVCs are common and often benign.

222
Q

A 76-year-old man with a history of chronic obstructive pulmonary disease presents with increasing dyspnea, cough, and a new finding of an S3 gallop on examination. His chest X-ray shows an enlarged cardiac silhouette. What is the most likely cause of his symptoms?**

  • A. Acute bronchitis
  • B. Exacerbation of COPD
  • C. Acute decompensated heart failure
  • D. Pneumonia
A

C. Acute decompensated heart failure

The presence of an S3 gallop and an enlarged cardiac silhouette on chest X-ray in a patient presenting with dyspnea and cough suggests acute decompensated heart failure.

223
Q

A 60-year-old woman with a history of aortic stenosis presents with syncope. She is noted to have a systolic ejection murmur and her ECG shows left ventricular hypertrophy. What is the most appropriate next step in management?**

  • A. Immediate surgical valve replacement
  • B. Cardiac catheterization
  • C. Holter monitoring
  • D. Start beta-blockers
A

B. Cardiac catheterization

Cardiac catheterization can help assess the severity of aortic stenosis and guide decisions about timing for surgical valve replacement, which may be necessary given her symptom of syncope.

224
Q

A 50-year-old man presents with acute onset of chest pain, dyspnea, and palpitations. He has a history of smoking 1 pack per day for 30 years. His ECG shows new T-wave inversions in leads II, III, and aVF. What is the most likely underlying cause of his presentation?**

  • A. Acute myocardial infarction
  • B. Chronic obstructive pulmonary disease (COPD)
  • C. Acute pericarditis
  • D. Pulmonary embolism
A

A. Acute myocardial infarction

New T-wave inversions in leads II, III, and aVF are suggestive of ischemia in the inferior wall of the heart, indicating an acute myocardial infarction, especially given his significant smoking history.

225
Q

A 55-year-old man with a known history of hypertension and a previous myocardial infarction is brought to the ED with severe dizziness and weakness. His blood pressure is 80/50 mmHg, pulse is 50 bpm, and he is diaphoretic. His ECG shows a wide QRS complex. What is the most likely diagnosis?**

- A. Ventricular tachycardia

- B. Complete heart block

- C. Sinus bradycardia

- D. Atrial fibrillation with slow ventricular response
A

B. Complete heart block

The presentation of severe dizziness, weakness, hypotension, bradycardia, and wide QRS complexes is consistent with complete heart block, a serious condition requiring immediate pacing.

226
Q

A 24-year-old woman presents to the emergency department after being found on a park bench, visibly distressed and hyperventilating. She reports that she thought she was having a heart attack and felt an overwhelming sense of doom. She has no significant past medical history but mentions that these episodes have happened several times over the past month, typically triggered by crowds. Which of the following is the most likely diagnosis?**
- A) Generalized Anxiety Disorder
- B) Panic Disorder
- C) Social Anxiety Disorder
- D) Posttraumatic Stress Disorder

A

B) Panic Disorder

The patient’s presentation with spontaneous episodes of intense anxiety featuring physiological symptoms (like hyperventilation) and fear of impending doom, occurring in a variety of settings and without specific triggers like traumatic events, is characteristic of Panic Disorder.

227
Q

A 33-year-old man is brought to the ER by police after he was found walking in traffic. He is agitated, yelling about being poisoned by celebrities, and appears unkempt. He has no known medical history and refuses to answer most questions. Based on the presentation, which of the following is the most likely diagnosis?**
- A) Bipolar Disorder
- B) Schizophrenia
- C) Substance Use Disorder
- D) Delirium

A

B) Schizophrenia

This patient exhibits classic symptoms of Schizophrenia, such as paranoia (delusions of poisoning), disorganized behavior (walking in traffic), and auditory hallucinations, alongside a deterioration in his social functioning (unkempt appearance).

228
Q

A 42-year-old woman with a known history of major depressive disorder presents to the emergency department complaining of increased sleep, appetite, and a lack of energy. She admits to having thoughts of suicide but denies a plan. She mentions that her antidepressant was changed a month ago. Which of the following actions is most appropriate for managing this patient?**
- A) Increase the dose of her current antidepressant
- B) Switch back to her original antidepressant
- C) Admit for psychiatric hospitalization
- D) Arrange for outpatient psychiatric follow-up

A

C) Admit for psychiatric hospitalization

The presence of active suicidal ideation, even without a specific plan, alongside a deterioration in her mood symptoms after a medication change, warrants acute inpatient psychiatric admission for stabilization and safety.

229
Q

A 30-year-old male is observed talking to himself while pacing back and forth in the emergency department waiting area. Upon interview, he claims he is having a discussion with a famous historical figure about his mission to save the world. He denies drug use and has no known history of mental illness. What initial approach is most appropriate for this patient?**
- A) Start an antipsychotic medication
- B) Conduct a urine drug screen
- C) Immediate physical restraint
- D) Detailed psychiatric evaluation

A

D) Detailed psychiatric evaluation

A comprehensive psychiatric assessment is crucial to differentiate between primary psychiatric conditions like schizophrenia or a psychotic disorder due to another medical condition. Drug use and medical causes should be ruled out through further investigation after the initial psychiatric assessment.

230
Q

A 55-year-old female with a history of chronic alcoholism presents to the emergency room complaining of severe anxiety, tremors, sweating, and a sense of impending doom. She had her last drink 24 hours ago. Which of the following is the most appropriate initial treatment?**
- A) Oral diazepam
- B) Intravenous fluids
- C) Admission to a medical floor
- D) Thiamine administration

A

A) Oral diazepam

This patient is likely experiencing alcohol withdrawal symptoms, which can include severe anxiety and autonomic hyperactivity. Benzodiazepines like diazepam are the treatment of choice for managing withdrawal symptoms.

231
Q

A 28-year-old man presents with irritability, difficulty concentrating, increased energy, and a decreased need for sleep for the past three days. He mentions he feels “on top of the world” and has been spending large amounts of money online. What is the most likely diagnosis?**
- A) Cyclothymic Disorder
- B) Bipolar I Disorder
- C) Bipolar II Disorder
- D) Borderline Personality Disorder

A

B) Bipolar I Disorder

The patient’s symptoms of elevated mood, increased activity, decreased need for sleep, grandiosity, and impulsivity (excessive spending) are indicative of a manic episode, consistent with Bipolar I Disorder.

232
Q

A 36-year-old woman comes to the emergency department after a co-worker noticed her slurring her words and appearing “out of it.” The patient is disoriented to time and place but recalls her name and age. Her medical history includes depression and anxiety. What should be the first step in management?**
- A) Complete a CT scan of the head
- B) Administer intravenous thiamine
- C) Perform a neurological exam
- D) Obtain a blood alcohol level

A

C) Perform a neurological exam

The first step should be a thorough neurological exam to assess for any focal deficits or signs that suggest a specific cause such as stroke, which could present with sudden confusion and speech disturbance.

233
Q

A 19-year-old college student is brought to the ER by friends who report that he has been increasingly withdrawn, has stopped attending classes, and was found muttering to himself about being controlled by aliens. He has no prior medical or psychiatric history. Which of the following is the most likely diagnosis?**
- A) Schizophreniform Disorder
- B) Acute Stress Disorder
- C) Schizoaffective Disorder
- D) Major Depressive Disorder with Psychotic Features

A

A) Schizophreniform Disorder

Schizophreniform Disorder is diagnosed when symptoms of schizophrenia (like delusions, hallucinations, and disorganized speech) are present for more than one month but less than six months. In this case, the acute onset and duration of symptoms suggest this diagnosis.

234
Q

A 22-year-old woman presents to the ER for an assessment after a sexual assault. She is visibly distressed, crying intermittently, and has difficulty recounting the event. What is the most important initial step in her care?**
- A) Immediate psychiatric evaluation
- B) Collection of forensic evidence
- C) Administration of post-exposure prophylaxis
- D) Ensuring her physical safety and comfort

A

D) Ensuring her physical safety and comfort

The primary initial step in managing a sexual assault survivor is to ensure physical safety and comfort, which helps establish trust and ease the process of further necessary interventions.

235
Q

A 45-year-old man with no known psychiatric history presents with a two-week history of depressed mood, insomnia, and anhedonia following the death of his spouse. He denies suicidal ideation. Given the clinical context, what is the most likely diagnosis?**
- A) Adjustment Disorder
- B) Major Depressive Disorder
- C) Complicated Grief
- D) Persistent Depressive Disorder (Dysthymia)

A

A) Adjustment Disorder

Adjustment Disorder is likely given the onset of depressive symptoms in response to a significant life stressor (spouse’s death) occurring within three months of the event. This condition is characterized by emotional or behavioral symptoms in response to an identifiable stressor.

236
Q

A 23-year-old male presents with fatigue, pallor, and jaundice. His peripheral blood smear shows spherocytes, and a Coombs test is negative. He reports a family history of similar symptoms. What is the most likely diagnosis?**
- A) Iron deficiency anemia
- B) Sickle cell anemia
- C) Hereditary spherocytosis
- D) Acute lymphocytic leukemia

A

C) Hereditary spherocytosis

Hereditary spherocytosis is characterized by hemolytic anemia, jaundice, and the presence of spherocytes on a blood smear, with a negative Coombs test indicating an intrinsic defect of the red cells rather than an autoimmune process.

237
Q

A 45-year-old woman presents with severe headache and petechiae after starting a new medication for chronic headaches two weeks ago. Her platelet count is 20,000/microliter. What is the most appropriate next step in management?**
- A) Administer intravenous immunoglobulin
- B) Discontinue the suspected medication
- C) Perform a bone marrow biopsy
- D) Administer a platelet transfusion

A

B) Discontinue the suspected medication

The patient’s presentation is suggestive of drug-induced thrombocytopenia, a condition where certain medications can cause a severe decrease in platelet counts. The first step should be to discontinue the offending medication.

238
Q

A 60-year-old man with a history of polycythemia vera presents to the emergency department complaining of blurred vision and headache. Examination reveals a ruddy complexion. Which complication is most likely associated with his underlying condition?**
- A) Aplastic anemia
- B) Hyperviscosity syndrome
- C) Acute leukemia
- D) Iron deficiency anemia

A

B) Hyperviscosity syndrome

Polycythemia vera can lead to hyperviscosity syndrome due to increased red cell mass, which can present with symptoms such as blurred vision and headache due to impaired blood flow.

239
Q

A 32-year-old female presents with fatigue and dyspnea on exertion. Laboratory tests reveal hemoglobin of 6 g/dL, MCV of 110 fL, and hypersegmented neutrophils on peripheral smear. Which of the following is the most likely diagnosis?**
- A) Iron deficiency anemia
- B) Thalassemia
- C) Vitamin B12 deficiency
- D) Acute blood loss

A

C) Vitamin B12 deficiency

The combination of low hemoglobin, high MCV, and hypersegmented neutrophils suggests a megaloblastic anemia, with vitamin B12 deficiency being a common cause.

240
Q

A 19-year-old college student presents with fever, sore throat, and fatigue. Physical examination shows splenomegaly. A peripheral blood smear is significant for atypical lymphocytes. What is the most likely diagnosis?**
- A) Acute lymphocytic leukemia
- B) Infectious mononucleosis
- C) Sickle cell anemia
- D) Hodgkin’s lymphoma

A

B) Infectious mononucleosis

Infectious mononucleosis, caused by the Epstein-Barr virus, typically presents with fever, pharyngitis, atypical lymphocytosis, and splenomegaly in a young adult.

241
Q

A 58-year-old male with a history of chronic obstructive pulmonary disease presents to the emergency department with increasing shortness of breath and a swollen leg. He has a low-grade fever. His D-dimer level is elevated. What is the most appropriate next diagnostic step?**
- A) Lower extremity ultrasound
- B) Sputum culture
- C) Echocardiography
- D) CT pulmonary angiography

A

A) Lower extremity ultrasound

Given the presentation of unilateral leg swelling and an elevated D-dimer, a lower extremity ultrasound is appropriate to assess for deep vein thrombosis, a common precursor to pulmonary embolism.

242
Q

A 27-year-old female presents with easy bruising and bleeding gums. Her platelet count is 45,000/microliter, and bone marrow biopsy shows increased megakaryocytes. What is the most likely diagnosis?**
- A) Acute myeloid leukemia
- B) Aplastic anemia
- C) Immune thrombocytopenic purpura (ITP)
- D) Vitamin K deficiency

A

C) Immune thrombocytopenic purpura (ITP)

ITP is characterized by autoimmune destruction of platelets, often presenting with symptoms like easy bruising, and a bone marrow biopsy typically shows increased megakaryocytes as the bone marrow attempts to compensate for peripheral destruction.

243
Q

A 40-year-old male with a known history of sickle cell disease presents with sudden onset of pain in his left leg and low-grade fever. His leg is tender to palpation but not swollen. What is the most likely cause of his symptoms?**
- A) Osteomyelitis
- B) Acute chest syndrome
- C) Bone infarction
- D) Deep vein thrombosis

A

C) Bone infarction

Patients with sickle cell disease often suffer from bone infarctions due to vaso-occlusive episodes, which can cause acute pain and sometimes fever, without the swelling typical of other conditions like DVT or osteomyelitis.

244
Q

A 50-year-old female presents with recurrent nosebleeds and menorrhagia. Laboratory tests reveal prolonged bleeding time, normal platelet count, and decreased factor VIII activity. What is the most likely diagnosis?**
- A) Von Willebrand disease
- B) Hemophilia A
- C) Thrombocytopenia
- D) Disseminated intravascular coagulation

A

A) Von Willebrand disease

Von Willebrand disease, a common inherited bleeding disorder, typically presents with mucocutaneous bleeding and may show a decrease in factor VIII activity due to its role in stabilizing von Willebrand factor.

245
Q

An 8-year-old child presents with pallor and fatigue. His father had a splenectomy at age 30. Blood smear shows bite cells and Heinz bodies. What is the most likely diagnosis?**
- A) G6PD deficiency
- B) Autoimmune hemolytic anemia
- C) Sickle cell disease
- D) Thalassemia

A

A) G6PD deficiency

G6PD deficiency can cause episodic hemolysis in response to oxidative stress, and is often hereditary. Bite cells and Heinz bodies are characteristic findings on the blood smear.