Chapter2 Flashcards

1
Q

Four results of muscle impairment

A

Muscle weakness
Slowness of movement
Loss of muscle power
Early muscle fatigue

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2
Q

By age 80 what percent of muscle strength is gone

A

40 -50 percent, also alpha motor neurons, and muscle cells

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3
Q

Motor unit changes in the elderly

A

Denervation of fibers, followed by reinervation by surrounding motor units resulting in larger motor units

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4
Q

Larger motor units cause what

A

Increased contraction and duration with decreased fine motor control and decreased speed of relaxation affecting coordination

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5
Q

Sarcopenia

A

Loss of muscle mass in elderly

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6
Q

Percentage of strength decline

A

8% per decade from 30-40 on ( Schiller 2000)

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7
Q

Therapy is not on.y to regain strength but also

A

Increase functional reserve

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8
Q

4 age related muscle changes

A

Decreased muscle mass
Increase fatigue
Increase fat in muscle
Increase connective tissue in muscle

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9
Q

Age related muscle changes can be altered by what 3 things

A

Exercise
Nutrition
Hormonal supplements

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10
Q

Muscle weakness is due to what 3 things

A

Decreased ability to activate muscle mass
Decreased quantity of muscle tissue(cross bridges)
Decrease force generated by cross bridges

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11
Q

3 changes in neural mechanisms

A

Undefined changes
Delay in conduction velocity
Delay in transmission

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12
Q

In Vivo muscle twitch is

A

Max velocity of a single muscle fiber

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13
Q

Characteristics of elderly in Vivo muscle contraction

A

Prolonged contraction with 50%delay in muscle relaxation impairing alternating movements and protective reactions during falls

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14
Q

5 Muscle changes that cause decreased endurance

A

Decreased blood supply and capillary density
Impairment of glucose transport
Lower mitochondrial density
Decreased activity of oxidative enzymes
Decreased rate of phosphor eating repletion

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15
Q

Muscle protein synthesis does what with age

A

Declines

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16
Q

Which protein is most important in skeletal muscle

A

MyHC

17
Q

What happens to MyHC with age

A

Decreased production

18
Q

Increased cytokines levels or inflammation cause what

A

Decreased IGF-1 an important modulator of muscle mass

19
Q

A cytokine causes what

A

Inflammation

20
Q

IL-6 is a cytokine which does what

A

Increase inflammation
Predicts level of disability in adults
Blocks Ifg-1 production

21
Q

Low IFG-1 results in what

A

Poor knee ext strength
Slower walk speeds
Decreased mobility