Chapter Three - Data Interpretation Flashcards
Causes of high neutrophils
Bacterial Infection
Tissue damage
Steroids
Causes of low neutrophils
Viral infection
Chemo or radiotherapy
Clozapine
Carbimazole
Causes of high lymphocytes
Viral infection
Lymphoma
CLL
Causes of low platelets
Reduced production
Infection
Drugs e.g. penicillaemine
Myelodisplasia, myelobrosis, myeloma
Causes of low platelets
Increased destruction
Heparin
Hypersplenism
DIC, ITP, HUS, TTP
Causes of high platelets
Bleeding
Tissue damage
Post splenectomy
Myeloproliferative disorders
Hypovolaemic hyponatraemia
Fluid losses
Addisons
Diuretics
Euvolaemic hyponatraemia
SIADH
Psychogenic polydipsia
Hypothyroidism
Hypervolaemic hyponatraemia
Heart failure
Renal failure
Liver failure
Nutritional failure
Thyroid failure
Causes of hypokalaemia
DIRE
Drugs - loop and thiazide
Inadequate intake or intestinal losses
Renal tubular acidosis
Endocrine - cushings and conns
Causes of hyperkalaemia
DREAD
Drugs - K sparing and ACEi
Renal failure
Endocrine - addisons
Artefact - clotted sample
DKA
Pre-renal AKI causes
Dehydration
Renal artery stenosis
Intrinsic AKI causes
INTRINSIC
Ischaemia - ATN
Nephrotoxic antibiotics
Tablets - ACEi NSAIDs
Radiological contrast
Injury - rhabdomyolysis
Negatively birefrigent crystals - gout
Syndromes - glomerulonephritis
Inflammation - vasculitis
Cholesterol emboli
Post-renal AKI causes
Stones, tumour, fibrosis, BPH, prostate cancer
When do you change the dose of thyroxine?
TSH <0.5 = decrease dose
TSH 0.5-5 = no action
>5 = increase dose
Features of digoxin toxicity
confusion
nausea
visual haloes
arrthymias
features of lithium toxicity
early - tremor
intermediate - tiredness
late - arrythmias, seizures, coma, renal failure, diabetes insipidus
features of phenytoin toxicity
Gum hypertrophy
Ataxia
Nystagmus
Peripheral neuropathy
Teratogenicity
features of gentamycin toxicity
Ototoxicity and nephrotoxic
features of vancomycin toxicity
Ototoxicity and nephrotoxicity
What is the normal peak range for gent? What do you do if the peak is out of range?
5-10
Adjust dose
What is the normal trough range for gent? What do you do if the trough is out of range?
<2
Adjust the dose interval