Chapter One - Basic Principles Flashcards
What affect do enzyme inducers have?
Increase enzyme activity and decrease the drug concentration
What are the inducers?
PC BRAS
Phenytoin
Carbamazapine
Barbiturates
Rifampicin
Alcohol
Sulphonylureas
What affect do enzyme inhibitors have
Decrease enzyme activity and increase the drug concentration
What are the inhibitors?
AO DEVICES
Allopurinol
Omperprazole
Disulfiram
Erythromycin
Valproate
Isoniazid
Ciprofloxacillin
Ethanol - acute
Sulphonamides
Which drugs are stopped before surgery?
I LACK OP
Isulin
Lithium
Anticoags
COCP/HRT
K sparing diuertics
Oral hypoglycaemics
Perindopril and other ACEi
When do you stop COCP/HRT before surgery?
4 weeks
When do you stop lithium before surgery?
Day before
When do you stop K sparing diuertics and ACEi before surgery?
Day of surgery