chapter one

Question 1

what are the five virus host cell interactions

Answer 1

• Productive infection
• Chronic Persistent infection
• Abortive infection
• Latent infection
• Transformation

Question 2

Productive infection

Answer 2

>

High production of new infectious progeny virus

>

Host cell is eventually killed within hours to days

Question 3

Chronic Persistent infection

Answer 3

>

Low level production of new infectious progeny virus
Host cell survives for long period of time
Host cell functions either not affected or partially impaired

Question 4

Abortive infection

Answer 4

>

Replication blocked at any step after attachment/adsorption
Host cell cannot supply some virus requirement, so productive infection 	terminated
Consequences to host cell either negligible (injury) or extensive (death)

Question 5

Latent infection

Answer 5

>

Virus becomes quiescent
Complete virus genome is conserved but little transcription/translation
Future event(s) may trigger reactivation of productive virus replication

Question 6

Transformation

Answer 6

> Results in heritable change in host cell
Interaction does not kill host cell but changes its phenotype, endowing the host cell with new properties
Change in phenotype leads to more vigorous growth, immortalization in vitro and malignancy in vivo
Cancer-causing viruses