Chapter 97 Superficial Antifungal Agents

Question 1

What are superfiical mycoses caused by?

Answer 1

Candida species (scalp, foot, skin, mucous membranes) & Dermatophytic infx (ringworm)

Question 2

Antifgunal superficial mycoses ending in -azoles (i.e., ketoconazole, itraconazole, flucanazole, etc.) are used? First line drug for tx?

Answer 2

For superficial mycoses on the skin with route being topical, broad spectrum of pathogenic fungi.

First line drug - Clotrimazole

Question 3

Ketoconazole should be administered how?

Answer 3

Limited oral usage due to toxicity, avoid oral usage for superficial fungal infx if possible

Question 4

Intravaginal use of Miconazole can interact with which medication?

Answer 4

Can intensify the anticoagulant medication warfarin, monitor INR if patient on both meds

Question 5

Griseofulvin is used? MOA?

Answer 5

ONLY for superficial mycoses, NOT EFFECTIVE FOR SYSTEMIC MYCOSES

Question 6

Allylamine antifungals end in (-ifine), what should be monitored closlely?

Answer 6

terbinafine needs CLOSE liver fx if taken oral; needs baseline and routine LFTs