Chapter 8- Transport In Animals Flashcards

1
Q

What is the need for specialised transport systems in multicellular animals?

A
  1. High metabolic demands- diffusion over the long distances is not enough to meet the demands.
  2. SA:V ratio- gets smaller as organisms get bigger. Diffusion distances increase, amount of SA available reduced.
  3. Transporting molecules:
    - hormones created in one place but needed in another.
    - waste products of metabolism from cells to excretory organs.
    - digested food from organ to every cell for use in respiration.
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2
Q

What is an open circulatory system?

A
  • a circulatory system with a heart but few vessels to contain the transport medium.
  • haemolymph is pumped straight from the heart through short vessels into the haemocoel of the animal.
  • found mainly in invertebrate animals. (Insects)
  • when heart relaxes, haemolymph is sucked back in via pores called ostia.
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3
Q

What is the haemocoel?

A

The large open body cavity of the animal.

  • in the haemocoel the transport medium is under low pressure.
  • comes into direct contact with the tissues and cells. This is where exchange (not gas) between the transport medium and the cells happens.
  • in this cavity, haemolymph directly bathes organs and tissues, allowing diffusion.
  • haemolymph moves around haemocoel due to movement of organism.
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4
Q

What is haemolymph?

A

Insect blood.

  • doesn’t carry oxygen or carbon dioxide.
  • transports food and nitrogenous waste products and the cells involved in defence against disease.
  • it circulates but steep diffusion distances for effective diffusion cannot be maintained.
  • the amount of haemolymph flowing to a particular tissue cannot be varied to meet changing demands.
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5
Q

What is a closed circulatory system?

A

The blood is enclosed in blood vessels and doesn’t not come directly into contact with the body cells.

  • the heart pumps blood around the body under pressure and quickly and the blood returns directly to the heart.
  • substances enter and leave the blood by diffusion through walls of blood vessels.
  • amount of blood flow adjusted by widening/narrowing blood vessels.
  • most contain a blood pigment that carries respiratory gases.
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6
Q

Where are closed circulatory systems found?

A

All vertebrate groups, including mammals.

- squid, earthworms, starfish

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7
Q

What is a single closed circulatory system?

A

Blood travels only once through the heart for each complete circulation of the body.
- blood passes through two sets of capillaries before returning to heart:
1. Exchanges oxygen and carbon dioxide.
2. Substances exchanged between blood and cells.
As a result of passing through 2 narrow vessels, blood pressure in system drops so blood returns slowly = limits efficiency so activity of animal is low.

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8
Q

Where can a single circulatory system be found?

A

In fish, however they are an exception to the fact of low activity due to the slow return of blood to the heart.

  • they have an efficient single circulatory system so can be very active. Mainly due to countercurrent system allowing max uptake of oxygen from water.
  • their body weight supported by water so don’t need to control body temp.
  • this reduces metabolic demands and combined with effective gaseous exchange, allows activeness even with single closed circulatory system.
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9
Q

What is a double closed circulatory system?

A

Blood travels through heart twice for each circuit of the body:
1. Pulmonary circulation- Blood pumped from heart to lungs to pick up O and drop off CO2. Returns to heart.
2. Systemic circulation- blood flows through hear and is pumped out all around body before returning again.
Each circuit only passes through one capillary network so high pressure and fast blood flow can be maintained. (Most efficient transport system)

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10
Q

Where are double closed circulatory systems found?

A

In active land animals that maintain their own body temp.

Most mammals and birds.

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11
Q

What is the role of elastic fibres, smooth muscle and collagen?

A

Elastic fibres- composed of elastin. Can stretch and recoil, providing vessel walks with flexibility.
Smooth muscle- contacts or relaxes which changes the size of the lumen.
Collagen- provides structural support to maintain shape and volume of vessel.

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12
Q

What are the arteries?

A
  • they carry blood away from the heart to the tissues of the body.
  • carry oxygenated blood, except the pulmonary artery.
  • blood is under higher pressure than in veins.
    Structure of artery:
    Tough outer layer(collagen) - muscle layer - elastic layer - endothelium- lumen.
    -largest artery = aorta (highest pressure flow)
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13
Q

Explain the role of elastic fibres in artery walls?

A
  • enable them to withstand force of blood pumped out the heart and stretch to an extent (due to collagen) to take larger volumes.
  • in between contractions of the heart, elastic fibres recoil and return to original length. This helps even out the surges of blood to give a continuous flow.
  • however you can still feel a pulse (surge of blood) as elastic fibres can’t completely eliminate it.
  • endothelium (lining if artery) is smooth so blood easily flows over it.
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14
Q

What is the pulmonary artery?

A

An artery that carries deoxygenated blood from the heart to the lungs.
During pregnancy, carries blood to the umbilical artery, which carries deoxygenated blood from the fetus to placenta.

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15
Q

What are the arterioles?

A
  • link the arteries and capillaries.
  • have more smooth muscle.
  • less elastin in walls than arteries as they have little pulse surge.
  • can constrict/dilate to control the flow of blood into individual organs.
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16
Q

What is vasoconstriction and vasodilation?

A

Vasoconstriction- smooth muscle in the arteriole contracts, constricting the vessel, prevents blood flowing into a capillary bed.

Vasodilation- smooth muscle in arteriole wall relaxes, blood flows through into the capillary bed.

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17
Q

What are capillaries?

A
  • microscopic blood vessels that link arterioles with the venules.
  • form extensive network through all tissues.
  • very small lumen. Red blood cells have to travel in single file.
  • substances exchanged through capillary walls between tissue cells and blood.
  • gaps between endothelial cells (make up capillary walls) relatively large. Substances pass out of capillaries into fluid surrounding cells from here.
  • except capillaries in CNS. Have very tight junctions in between.
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18
Q

What blood do the capillaries carry?

A

-Blood entering the capillaries from the arterioles= oxygenated.
- by the time it leaves for the venules = deoxygenated.
Lungs and placenta= exceptions:
- deoxygenated blood enters capillaries, oxygenated leaves into venules.

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19
Q

How are the capillaries adapted for their role?

A
  • provide a large surface area for the diffusion of substances into/out of blood.
  • total cross-sectional area is greater than the arteriole supplying them, so rate of blood flow falls, allowing more time for exchange of materials by diffusion between blood and cells.
  • walls = single endothelial cell thick = thin layer for diffusion.
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20
Q

What are the veins?

A
  • carry deoxygenated blood away from body cells towards heart. Except pulmonary/umbilical vein.
  • don’t have a pulse. Surges from heart pumping are lost as blood passes through the narrow capillaries.
  • hold large reservoir of blood (60% of bloods volume at any one time)
  • blood pressure very low compared to arteries.
  • walls contain lots of collagen, little elastic fibre. Vessels have large lumen, and smooth thin lining (endothelium) for easy blood flow.
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21
Q

How is deoxygenated blood returned to the heart?

A

-deoxygenated blood flows from capillaries to venules to larger veins.
Finally it reaches the two main vessels, carrying deoxy blood back to heart:
- Inferior vena cava (from lower body parts)
-superior vena cava (from head+upper body).
The blood is under low pressure and needs to move against gravity so there are adaptations to help this.

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22
Q

What are venules?

A
  • links the capillaries with the veins.
  • very thin walls with a little smooth muscle.
  • several venules join to form a vein.
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23
Q

What are the 3 adaptations to help deoxy blood flow from veins back to heart?

A
  • most veins have one way valves (infoldings of inner lining)at intervals. If blood starts to flow backwards, valves close.
  • many bigger veins run between the big,active body muscles. When they contract, they squeeze veins, forcing blood up towards heart. (Valves prevent back flow when muscles relax)
  • breathing movements of chest act as pump. Pressure changes and squeezing actions move blood up.
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24
Q

What is the blood?

A

The main transport medium of the human circulatory system. Also considered a type of connective tissue.

  • consists of plasma (a yellow liquid) which carries dissolved glucose, amino acids, mineral ions, hormones and plasma proteins.
  • plasma =93% water. (Therefore Polar solvent)
  • Has rbc(most) and wbc( least) and platelets.
  • plasma makes up 55% of the blood by volume. (Rest is made up by stuff it carries^)
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25
Q

What are the main plasma proteins and their roles?

A
  1. Albumin- important for maintaining osmotic potential of blood.
  2. Fibrinogen- important in blood clotting.
  3. Globulins- involved in transport and the immune system.
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26
Q

What are platelets?

A

Aka thrombocytes
Fragments of large cells called megakaryocytes found in the red bone marrow.
- involved in clotting mechanism of blood.
- carried by the plasma in the blood.

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27
Q

Functions of the blood

A
  • contributes to the maintenance of body temp. (Thermoregulation)
    -Acts as a buffer, minimising pH changes.
    Transport of:
  • oxygen to and carbon dioxide from respiring cells.
  • digested food from small intestine.
  • nitrogenous waste products from cells to excretory organs.
  • hormones.
  • food molecules from storage components to cells that need.
  • platelets to damaged areas.
  • cells/antibodies involved in immune system.
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28
Q

What is oncotic pressure?

A

The tendency of water to move into the blood by osmosis.

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29
Q

What is hydrostatic pressure?

A

The pressure from the surge of blood that occurs every time the heart contracts.

30
Q

Explain the osmotic effect of the plasma proteins.

A
  • The plasma proteins (especially albumin) give the blood in the capillaries high solute potential so therefore low water potential as compared to surrounding fluid.
  • due to oncotic pressure, water has a tendency to move into the blood in the capillaries via osmosis from the surrounding fluid.
31
Q

Explain the movement into and out of the capillaries. (Formation of tissue fluid)

A

At the arterial end of capillaries:
- blood entering from arterioles has high hydrostatic pressure. It is higher than the oncotic pressure attracting water in by osmosis so fluid is squeezed out. This fluid fills spaces between cells and is called tissue fluid.
At venous end:
- As blood moves through capillary, hydrostatic pressure decreases as fluid has moved out. Oncotic pressure= greater than hydrostatic so water moves back in via osmosis.
(By the time blood returns to veins, 90% of tissue fluid back in blood vessels)

32
Q

What is tissue fluid? made up of?

A

The fluid that fills spaces between cells, after being forced out of arterial end of capillaries
Same composition as plasma but without RBCs and plasma protein.
Diffusion takes place between the blood and the cells through the tissue fluid.

33
Q

What is lymph?

A

Not all the tissue fluid returns to the capillaries.
10% drains into a system of blind-ended tubes called lymph capillaries. Here it is known as Lymph.
- the lymph capillaries join up to form larger lymphatic vessels.

34
Q

What is the composition of lymph?

A
  • similar composition to plasma/tissue fluid but has less O2 and nutrients.
  • also contains fatty acids, which have been absorbed into lymph from villi of small intestines.
35
Q

How is lymph fluid transported and to where?

A

Transported through the lymphatic vessels by the squeezing of body muscles.

  • one way valves prevent backflow.
  • eventually it returns into the blood, flowing into the right and left subclavian veins (under the clavicle).
36
Q

What are lymph nodes and lymphocytes? Function?

A

Along the lymph vessels are the lymph nodes.
Lymphocytes build up in the lymph nodes when necessary and produce antibodies which are then passed into the blood.
- lymph nodes also intercept bacteria from the lymph, which are ingested by phagocytes in the nodes.
Lymphatic system plays a major role in the defence mechanisms of the body.

37
Q

What do enlarged lymph nodes show?

A

A sign that the body is fighting of an invading pathogen.

This is why doctors examine the neck, armpits, stomach or groin as these are the sites if major lymph nodes/glands.

38
Q

What is the heart (mammals)?

A

A complex, four chambered muscular bag found in the chest enclosed by the ribs and sternum.

39
Q

What is the heart made up of?

A

Cardiac muscle:
-contracts and relaxes in a regular rhythm.
- does not get fatigued or need to rest like skeletal muscles.
- coronary arteries supply the muscle with the oxygenated blood needed to keep contracting and relaxing.
The heart is surrounded by inelastic pericardial membranes which prevent it from over distending with blood.

40
Q

Structure of the right side of the heart?

A
  • superior vena cava
  • right pulmonary artery and vein.
  • right atrium
  • tricuspid valve (right atrioventricular valve)
  • right ventricle.
  • inferior vena cava.
41
Q

Structure of left side of heart?

A
  • left pulmonary artery and veins
  • left atrium.
  • bicuspid valves (left atrioventricular valves).
  • left ventricle.
  • thick muscular wall of left ventricle.
42
Q

Structure of middle of the heart?

A
  • Carotid arteries.
  • aorta.
  • semilunar valves.
  • septum. (Inner dividing wall which prevents mixing of oxy and deoxy 🩸)
43
Q

What is diastole?

A

In diastole:

  • the heart relaxes.
  • atria and then the ventricles fill with blood.
  • volume increases.
  • pressure decreases.
  • blood pressure in arteries is at minimum.
44
Q

What is systole?

A
  • atria contract (atrial systole).
  • ventricles contract (ventricular systole).
  • pressure in heart increases dramatically as blood is forced out the right side towards the lungs and out of the left to the rest of the body.
  • volume and pressure of blood are low at the end of systole.
  • blood pressure in arteries is at maximum.
45
Q

SAN and its role?

A

A wave of electrical excitation begins in the pacemaker area called the sino-atrial node (SAN).

  • causes the atria to contract and so initiating a heartbeat.
  • a layer of non-conducting tissue prevents the excitation passing directly to the ventricles.
46
Q

AVN and its role?

A

The electrical activity from the SAN is picked up by the atrio-ventricular node (AVN).

  • the avn imposes a slight delay which allows the atria to fully contract and pass maximum blood to ventricles before they start contracting.
  • it then stimulates the bundle of his.
47
Q

What is the bundle of His and its role?

A

A bundle of conducting tissue made up of purkyne fibres which penetrate through the septum between the ventricles.
- the bundle of His splits into 2 branches and conducts the wave of excitation to the apex (bottom) of the heart.

48
Q

What happens at the apex (electrical impulse)?

A
  • The purkyne fibres spread out through the walls of the ventricles on both sides.
  • the spread of excitation triggers the contractions of the ventricles, starting at the apex.
  • contractions starting at the apex allows more efficient emptying of ventricles.
49
Q

Explain the route of blood when it enters the heart till it leaves.

A
  1. Deoxy 🩸enters right atrium from the vena cavas. As it flows in, pressure builds up till tricuspid valve opens and allows blood into right ventricle.
  2. When atrium and ventricle are filled, atrium contracts, blood all forced to r ventricle.
  3. R ventricle starts contracting, t valve closes. Pumps deoxy 🩸through semilunar valves into pulmonary artery (takes to lungs).
  4. At same time, oxy🩸from lungs enters left atrium from pulmonary vein. As pressure builds b valve opens. L ventricle also fills with 🩸.
  5. Atrium contracts, forces all blood into L ventricle. L ventricle contracts, b valve closes, oxy 🩸 pumped through s valves into aorta to whole body.
50
Q

Role of tendinous cords in heart?

A

Make sure that when the atrioventricular valves close they aren’t turned inside out by the pressures exerted when the ventricles contract.

51
Q

What is an electrocardiogram?

A

Measures the spread of the electrical excitation through the heart in order to record what happens when it contracts.
This recording of electrical activity = ECG.
Used to help diagnose heart problems.

52
Q

How does an ECG work?

A

Doesn’t directly measure the electrical activity of your heart.
It measures tiny electrical differences in the skin which result from the heart’s electrical activity.
- to pick up these tiny changes, electrodes are stuck painlessly to clean skin to get the good contacts needed for reliable results.
- signals from each electrode are fed into a machine that produces the ECG.

53
Q

Normal ECG.

A

Beats evenly spread.

Rate = 60-100 / min.

54
Q

Tachycardia.

A

Heart beat is very rapid.
Over 100 bpm.
- often normal during exercise, fever, fright or anger.
- when abnormal may be caused by problems in the electrical control of the heart.

55
Q

Bradycardia.

A

Heart rate slows down to below 60bpm.

  • many people have bradycardia due to being fit. Training makes the heart beat slowly and more efficiently.
  • severe bradycardia may require a pacemaker to keep the heart beating steadily.
56
Q

Ectopic heart beat.

A

Extra heart beats that are out of rhythm.
Most people have atleast one a day.
- usually normal but can be linked to serious illness when frequent.

57
Q

Atrial fibrillation.

A

Is an example of arrhythmia (abnormal rhythm of the heart).

  • rapid electrical impulses generated in the atria.
  • they contact very fast (fibrillate) up to 400 times/min.
  • however don’t contract properly and only some impulses are passed to ventricles which contract less often.
  • as a result heart does not pump blood effectively.
58
Q

Adaptations of erythrocytes.

A
  1. Biconcave shape- has a larger surface area available for diffusion of gases. Also helps them pass through narrow capillaries.
  2. Lose their nucleus by the time they enter the circulation- maximises amount of haemoglobin that can bind to the cell.
  3. No nucleus limits their life span. Only 120 days approx.
59
Q

What is haemoglobin?

A

The red pigment that carries oxygen and gives erythrocytes their colour.
- is a very large globular conjugated protein made up of four peptide chains, each with an iron-containing haem prosthetic group.
- each haemoglobin molecule can bind to four oxygen molecules.
Oxygen binds loosely to haemoglobin forming oxyhemoglobin. Reaction is reversible.

60
Q

Explain how oxygen is picked up.

A
  • When erythrocytes enter the lung capillaries, O2 levels in the cells are low. This creates steep conc gradient between erythrocytes and air in alveoli.
  • air moves into erythrocytes and bind to haemoglobin.
  • (positive cooperativity.)
  • as the O2 is bound to the haemoglobin, the free O2 conc in erythrocyte stays low, so a steep conc gradient is maintained until all the haemoglobin is saturated with O2.
  • Hb has high affinity for oxygen.
61
Q

What is meant by positive cooperativity?

A

The arrangement of the Hb molecule means that as soon as one oxygen molecule binds to a haem group, the molecule changes shape, making it easier for the next oxygen molecules to bind.
This is known as positive cooperativity.

62
Q

Explain how oxygen is dropped of.

A

One the blood reaches body tissues:

  • conc of O2 in cytoplasm of body cells is lower than in erythrocytes.
  • so oxygen moves out of erythrocytes down a concentration gradient.
  • once the first O2 molecule is released by the haemoglobin, the molecule again changes shape and it becomes easier to remove the remaining oxygen molecules.
  • here haemoglobin has a low affinity for oxygen. There is also lower pH in tissues than lungs.
63
Q

What is meant by partial pressure?

A

defined as the pressure of a single gas component in a mixture of gases.
-It corresponds to the total pressure which the single gas component would exert if it alone occupied the whole volume.

64
Q

Explain the oxygen dissociation curve.

A
  • % saturation of Hb plotted against the partial pressure of O2 (pO2).
  • shows the affinity of haemoglobin for oxygen.
    As pO2 increases, % saturation increases:
    -at low pO2 (respiring cells), few haem groups are bound to oxygen so Hb doesn’t carry much O2.
  • at higher pO2, more haem group become bound to o2 making it easier for oxygen to be picked up due to positive cooperativity.
  • once all haem group are bound, Hb is saturated and has high affinity for o2 (in lungs)
65
Q

Explain the Bohr effect and its importance.

A

At high pCO2, Hb has lower affinity for oxygen so that it is easier go drop it off.
Important because:
- in active tissues with high pCO2, haemoglobin gives up O2 more easily to meet demands.
- in the lungs where CO2 levels in air are low, oxygen bunds to haemoglobin molecules easily.

66
Q

Explain how fetal haemoglobin is different to adult haemoglobin.

A

When a fetus is developing, it is dependent on its mother for oxygen supply.
Fatal haemoglobin has a higher affinity for oxygen as some oxygen is lost from the bloodstream before it reaches the placenta.
- higher affinity allows maximum oxygen to be transferred.

67
Q

Myoglobin.

A

Is a molecule with similar structure to Hb but has only one haem group.

  • has a very high affinity for oxygen even at very low partial pressures.
  • this means oxymyoglobin will only dissociate when O2 levels are low.
  • found in muscle cells where it acts as a oxygen reserve.
68
Q

3 ways in which CO2 can be transported from the tissues to lungs.

A
  • 5% is carried dissolved in plasma.
  • 10-20% is combined with amino groups in polypeptide chains of haemoglobin to form carbaminohaemoglobin.
  • 75-85% is converted into hydrogen carbonate ions (HCO3^-) in the cytoplasm of RBCs.
69
Q

Explain picking up of Co2 as hydrogen carbonate ions.

A
  • CO2 reacts slowly with water to form carbonic acid. This is reversible and is catalysed by carbonic anhydrase which is present in cytoplasm of RBCs in high levels.
  • the carbonic acid then dissociates to form hydrogen ions and hydrogen carbonate ions.
  • the -ve HCO3- ions move out the erythrocytes into the plasma by diffusion down a conc gradient. -ve Cl- ions move into the erythrocytes which maintains the electrical balance of the cell.
    = known as chloride shift.
70
Q

Why is Co2 converted to hydrogen carbonate ions?

A

It allows the erythrocytes to maintain a steel conc gradient for carbon dioxide to diffuse from respiring tissues into the erythrocytes.

71
Q

Explain how carbon dioxide is dropped off.

A
  • when blood reaches the lung tissue where there is low conc of CO2, carbonic anhydrase catalyses the reverse reaction.
  • carbonic acid is broken down into CO2 and water.
  • hydrogen carbonate ions diffuse back into the erythrocytes and reacts with H+ ions to form more carbonic acid.
  • when this is broken down by carbonic anhydrase it releases free carbon dioxide, which diffuses put of the blood into lungs.
  • Cl- ions diffuse out of RBCs back into the plasma down an electrochemical gradient.
72
Q

Role of haemoglobin in dropping off of CO2?

A

Haemoglobin in the erythrocytes acts as a buffer and prevents pH changes by accepting free H+ ions in a reversible reaction to form haemoglobinic acid.
- this causes haemoglobin to release all the oxygen it’s carrying.