Chapter 8 - Anti-infective Agents Flashcards
What is the goal of the treatment
Interfere with normal functioning of the invading organism to prevent from reproducing and causes cell death without affecting the host cell.
What statuses should you worry about with a child taking antibiotics
Nutritional status and hydration
Are antibiotics safe for pregnancy and lactation?
No.
Cross breast milk and placenta leading to go is affects in the fetus.
What statuses do you assess with an older patient taking antibiotics
List 6
Hepatic, gi, renal, neuro, nutritional status and hydration.
Which drug prevents the cells of the invading organism from using substances essential to growth and reproduction
Sulfonamides and mycobacterials
What drugs interfere with the steps involved in protein synthesis?
Aminoglycosides and macrolides
Interfere with dna synthesis of the cell, inability to divide and reproduce.
Floroquinolones
Producing an enzyme inactivating the drug
Altering permeability of the cell
Altering binding sites
Producing a chemical antagonist
Are an example of what?
Acquired resistance
What develops resistance through actual genetic mutation
Microbes
Do anti-infectives invade the host.
Yes, there has been no anti infective drug that has been developed that doesn’t affect the host.
Which drug is used to treat malaria and rheumatoid disease?
Chloroquine
What is something to re beer about the effects of cholooquine
Accumulate in the retina and optic nerve and cause blindness
Pseudomonas and proteus superinfection are associated with which spectrum of antibiotic
Broad spectrum
Which drug accumulates in the 8th cranial nerve causing hearing loss, vertigo, and dizziness
Aminoglycosides
Which gram stain is associated with gi and gu infections
Negative
