Chapter 2 - Drugs And The Body Flashcards
Analogy for receptor sites
Lock and key
Nearby enzymes break down reacting chemicals and open receptor sites for further stimulation
Agaonists
Act directly with receptor sites, with natural chemicals that would normally occur at that site
Ex. insulin moves glucose into the cell
Noncompetitive Antagonist
Reach with specific receptor sites on a cell, and prevent reactions with another chemical with s different receptor site on that cell.
What system do enzymes work
Cascade.
Activates one chemical then that chemical reacts with another.
What are the cells that reproduce rapidly and need and increased drug dosage
Bone marrow, gi, hair follicles
Pharmacodynamics vs pharmacokinetics
Pharmacodynamics- how the drug acts on the body
Pharmacokinetics- how the body work on the drug
List four phases of drug digestion
Absorption
Distribution
Biotransformarion
Excretion
Absorption
The time it takes from the drug is introduced to reach the circulating fluids
Binders do what?
Used to bark down in certain acidity and break down in certain acidities
Step such acidification is higher and drug is exposed to acid more longer
How ar drugs given IM absorbed
Must reach the capillaries in the muscle and then sent in circulation.
Men reach peak levels faster than women
Passive diffusion
Occurs against a concentration gradient
Doesn’t require an energy
Name the 4 ways drugs act
Replace/substitute missing chemicals
Increases and stimulate certain cells
Depress cellular activity
Interfere functioning of foreign cells
Active diffusion
Does require energy to transport a molecule against a membrane
No lipid solvable drugs can’t be transferred through the what
Blood brain barrier
First pass effect
Where most of the drug is destroyed and never reaches a therapeutic level
