Chapter 8 & 9 Flashcards
What is biomarker assessment?
What are characteristics of a nutritional biomarker?
*Involves the use of biologically available chemicals inside the body that perform as objective indicators of health/nutrition status
Involves a nutritional biomarker:
* An organic test used as an indicator of nutritional
status if it relates to the intake or metabolism of dietary components
* Can be a biochemical, functional, or clinical index of the status of an essential nutrient / dietary component
Purpose of biomarker assessment?
*Help clinicians, researchers, and policy makers
make diet and nutrition recommendations to
address disease and improve both individual and public health
*Is more objective and precise for measuring nutritional status than community and dietary
assessments are
Benefits of biomarker assessment?
*Has no bias of self-reported dietary intake errors
*Has no challenge of intra-individual and diet variability
*In the nutrition framework, biomarkers are classified as markers of exposure, status, and function or effect
What is the difference between function and effect biomarkers
*Function biomarkers: help describe the role of specific nutrients and potential interactions between different nutrients in biological
systems.
*They also classify the roles of nutrients across the lifespan and under different physiological
states.
*Effect biomarkers: help us understand the direct and indirect results—that is, those affecting cells and those affecting system function—of a nutrient deficiency.
What does creatinine protein measure?
What does high value indicate?
Measures kidney function, high with muscle wasting or
malnutrition
What does dietary protein measure?
Measures nutrient intake
What does high and low Albumin indicate?
Low with acute infection, trauma
High with dehydration
What do abnormal Prealbumin levels indicate?
high/low with liver disease; inflammation
What does Transferrin do?
What nutritional status does it correlate with?
*Transports iron from absorption centers in the duodenum (intestines) and white-blood-cell
macrophages to all tissues
*Not a reliable indicator of nutritional status alone
What does high Retinol Binding Protein (RBP) indicate?
High with chronic illnesses (i.e. Type 2 Diabetes)
What does low and high serum Ferritin (Iron) indicate?
Low with iron-deficiency anemia
High in autoimmune conditions
What does high Soluble Transferrin Receptor (sTfR) indicate?
High with iron-deficiency anemia
What can an abnormal Hematocrit indicate?
High with sickle-cell anemia, thalassemia, and iron deficiency
What does abnormal Mean Corpuscular Hemoglobin (MCH) indicate?
Low with iron deficiency and thalassemia
High with macrocytosis
What does abnormal Mean Corpuscular Volume (MCV) indicate?
High levels indicate B12 and/or folate deficiency
High/Low indicates iron-deficiency anemia
What does abnormal Hemoglobin (Hgb) indicate? When combined with what other factors?
When low in combination with low HCT & high/low MCV, indicates iron-deficiency anemia
What does abnormal zinc levels indicate?
Low in urine/blood with acute infection/trauma, GI malabsorption, or nutrient deficiency
Often low in combination with low albumin
High in urine indicates too much dietary intake
What does low calcium indicate?
Low levels indicate hypocalcemia
What does abnormal Iodine indicate?
Low in cases of hypothyroidism, mental retardation, goiter, cretinism, developmental irregularities
What does abnormal Phosphorous (P, PO4) levels indicate?
high/low related to phosphorus/calicum-balance related
conditions
What does abnormal Potassium (K) indicate?
High in hypkalemia; low in hypokalemia
What does abnormal sodium (Na) levels indicate)?
Low with hyponatremia (due to diarrhea/vomiting,
diuretics, kidney disease
High with hypernatremia (due to dehydration, Cusher’s Syndrome
What does Vitamin A abnormal levels indicate?
Low with dietary deficiency
May be artificially low with severe protein-calorie malnutrition
What does abnormalities in Vitamin D indicate?
Low with autoimmune conditions, Type II diabetes, rickets, osteopenia, osteoporosis Low with poor dietary intake/low sunlight
What can abnormal vitamin C indicate?
Deficiency rare, low with chronic smoking