Chapter 7 Other blood group systems

Question 1

This type of antigen is only inherit one from each parent
It is also developed at birth

Answer 1

Kell Antigens

Question 2

What are the two major antigens of Kell antigens.

Answer 2

K (K1) and k (K2/cellano)

Question 3

This antigen is known as penney and is a low-frequency antigen

Answer 3

Kp^a

Question 4

This antigen is known as rautenburg and is a high-frequency antigen

Answer 4

Kp^b

Question 5

This antigen is known as sutter

Answer 5

Js^a

Question 6

This antigen is known as matthews

Answer 6

Js^b

Question 7

K, k, kpa, kpb, Jsa, Jsb is apart of what blood group antigens?

Answer 7

Kell antigens

Question 8

This type of antigen group have disulfide-bonded regions on the glycoproteins. This makes them sensitive to sulfhydril reagents?

Answer 8

Kell Antigens

Question 9

RBC that lacks expression of Kell glycoprotein?

Answer 9

K0 or Kellnull phenotype

Question 10

Lacks all Kell system antigens?

Answer 10

K0 or Kellnull phenotype

Question 11

Expressed elevated levels of related Kx antigens?

Answer 11

K0 or Kellnull phenotype

Question 12

As a result of red blood cell immune stimulation, K0 individuals can develop what?

Answer 12

anti-Ku

Question 13

In the Kell group what are the high-incidence alleles?

Answer 13

k, Kpb, and Jsb

Question 14

In the Kell group what are the low-incidence alleles?

Answer 14

K, kpa, and Jsa

Question 15

This blood group is a sex linked gene (x chromosome)

Answer 15

Kx Blood Group system

Question 16

This blood group is genetically separate from Kell but phenotypically related

Answer 16

Kx blood group

Question 17

What is McLeod Phenotype?

Answer 17

Individuals who lacked Kx antigen that may demonstrate RBC abnormalities

Question 18

What are some symptoms of McLeod Phenotype?

Answer 18

RBC abnormalities
Muscular and neurologic defects
Increased creatine kinase

Question 19

What is McLeod Syndrome associated with?

Answer 19

Chronic granulomatous disease

Question 20

This blood group have antigens developed at birth and is destroyed by enzymes

Answer 20

Duffy Blood group

Question 21

What are the codiminant alleles for Duffy Blood Group

Answer 21

Fya and Fyb

Question 22

What are the antibodies of Duffy

Answer 22

Anti-Fya and Anti-Fyb

Question 23

Certain malarial parasites will not invade what

Answer 23

Fy (a-b-) negative cells

Question 24

Fya and Fyb acts as a receptor for what?

Answer 24

the merozoite to attach to the RBC

Question 25

What are the 3 antigens of Kidd

Answer 25

Jka, Jkb, and Jk3

Question 26

Jk3 is present whenever what are present?

Answer 26

Jka and Jkb

Question 27

These kidd antibodies is a common cause of delayed hemolytic transfusion reactions

Answer 27

Anti-JKa and Anti-Jkb

Question 28

These antigens exist on chromosome 19

Answer 28

Lutheran Antigen

Question 29

These antigens are weakly expressed on cord blood cells

Answer 29

Lutheran Antigens

Question 30

This type of Lutheran Antibodies may occur without RBC stimulation, shows mixed-field pattern, and mild cases of HDFN

Answer 30

Anti-Lua

Question 31

This type of Lutheran Antibodies are rare due to high incidence of antigen, shows mixed-field pattern and is associated with transfusion reactions

Answer 31

Anti-Lub

Question 32

This type of antigen are manufactured by tissue cells and secreted into body fluids

Answer 32

Lewis antigens

Question 33

Lea and Leb are not what

Answer 33

alleles

Question 34

This system depends on Hh, Se, and Le gene

Answer 34

Lewis system

Question 35

If the Le gene is inherited what substance is produced?

Answer 35

Lea

Question 36

Le, H, and Se genes must all be inherited to convert what?

Answer 36

Lea to Leb

Question 37

Lewis Antibodies are produced by what?

Answer 37

Le(a-b-)

Question 38

Anti-Lea binds what and may cause hemolysis in vitro

Answer 38

Complement

Question 39

Neutralization can confirm the presence or eliminate reactions with what antibody

Answer 39

Lewis antibodies

Question 40

patient Serum + Lewis substance = what?

Answer 40

0

Question 41

Patient serum + saline control = what?

Answer 41

1+

Question 42

Neutralized serum + Le(a+b+) = what?

Answer 42

Anti-leb (or a) confirmed

Question 43

True or false are I and i antigens are antithetical antigens?

Answer 43

False, they are not anthithetical antigens

Question 44

What are P1PK antigens?

Answer 44

P1 and Pk

Question 45

What are the 3 phenotypes of P1PK?

Answer 45

P1, P2, and null (p)

Question 46

This antibody is found in P2 individuals, IgM; enhanced by ezymes, non-RBC stimulated and can be neutralized by P1 substance

Answer 46

Anti-P1

Question 47

This antibody is associated with cold paroxysmal hemoglobinuria, IgG (Donath-Landsteiner antibody) and may appear in children after viral infections?

Answer 47

Autonanti-P

Question 48

This antibody can occur in individuals with the null phenotype, causes hemolysis in vitro and is clinically significant

Answer 48

Anti-PP1Pk

Question 49

This is coded by Glycophorin A, differ positions on 1 and 5 and is on glycophorin A (GPA)

Answer 49

M and N

Question 50

This is coded by glycophorin B, differ at position 29

Answer 50

S, s, and U

Question 51

This antibody is most frequently found in dialysis patients that due to formaldehyde-sterilized instruments

Answer 51

Anti-N