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Blood Banking > Chapter 7 Other blood group systems > Flashcards

Chapter 7 Other blood group systems Flashcards

Exam 3

1
Q

This type of antigen is only inherit one from each parent
It is also developed at birth

A

Kell Antigens

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2
Q

What are the two major antigens of Kell antigens.

A

K (K1) and k (K2/cellano)

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3
Q

This antigen is known as penney and is a low-frequency antigen

A

Kp^a

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4
Q

This antigen is known as rautenburg and is a high-frequency antigen

A

Kp^b

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5
Q

This antigen is known as sutter

A

Js^a

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6
Q

This antigen is known as matthews

A

Js^b

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7
Q

K, k, kpa, kpb, Jsa, Jsb is apart of what blood group antigens?

A

Kell antigens

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8
Q

This type of antigen group have disulfide-bonded regions on the glycoproteins. This makes them sensitive to sulfhydril reagents?

A

Kell Antigens

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9
Q

RBC that lacks expression of Kell glycoprotein?

A

K0 or Kellnull phenotype

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10
Q

Lacks all Kell system antigens?

A

K0 or Kellnull phenotype

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11
Q

Expressed elevated levels of related Kx antigens?

A

K0 or Kellnull phenotype

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12
Q

As a result of red blood cell immune stimulation, K0 individuals can develop what?

A

anti-Ku

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13
Q

In the Kell group what are the high-incidence alleles?

A

k, Kpb, and Jsb

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14
Q

In the Kell group what are the low-incidence alleles?

A

K, kpa, and Jsa

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15
Q

This blood group is a sex linked gene (x chromosome)

A

Kx Blood Group system

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16
Q

This blood group is genetically separate from Kell but phenotypically related

A

Kx blood group

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17
Q

What is McLeod Phenotype?

A

Individuals who lacked Kx antigen that may demonstrate RBC abnormalities

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18
Q

What are some symptoms of McLeod Phenotype?

A

RBC abnormalities
Muscular and neurologic defects
Increased creatine kinase

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19
Q

What is McLeod Syndrome associated with?

A

Chronic granulomatous disease

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20
Q

This blood group have antigens developed at birth and is destroyed by enzymes

A

Duffy Blood group

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21
Q

What are the codiminant alleles for Duffy Blood Group

A

Fya and Fyb

22
Q

What are the antibodies of Duffy

A

Anti-Fya and Anti-Fyb

23
Q

Certain malarial parasites will not invade what

A

Fy (a-b-) negative cells

24
Q

Fya and Fyb acts as a receptor for what?

A

the merozoite to attach to the RBC

25
Q

What are the 3 antigens of Kidd

A

Jka, Jkb, and Jk3

26
Q

Jk3 is present whenever what are present?

A

Jka and Jkb

27
Q

These kidd antibodies is a common cause of delayed hemolytic transfusion reactions

A

Anti-JKa and Anti-Jkb

28
Q

These antigens exist on chromosome 19

A

Lutheran Antigen

29
Q

These antigens are weakly expressed on cord blood cells

A

Lutheran Antigens

30
Q

This type of Lutheran Antibodies may occur without RBC stimulation, shows mixed-field pattern, and mild cases of HDFN

A

Anti-Lua

31
Q

This type of Lutheran Antibodies are rare due to high incidence of antigen, shows mixed-field pattern and is associated with transfusion reactions

A

Anti-Lub

32
Q

This type of antigen are manufactured by tissue cells and secreted into body fluids

A

Lewis antigens

33
Q

Lea and Leb are not what

A

alleles

34
Q

This system depends on Hh, Se, and Le gene

A

Lewis system

35
Q

If the Le gene is inherited what substance is produced?

A

Lea

36
Q

Le, H, and Se genes must all be inherited to convert what?

A

Lea to Leb

37
Q

Lewis Antibodies are produced by what?

A

Le(a-b-)

38
Q

Anti-Lea binds what and may cause hemolysis in vitro

A

Complement

39
Q

Neutralization can confirm the presence or eliminate reactions with what antibody

A

Lewis antibodies

40
Q

patient Serum + Lewis substance = what?

A

0

41
Q

Patient serum + saline control = what?

A

1+

42
Q

Neutralized serum + Le(a+b+) = what?

A

Anti-leb (or a) confirmed

43
Q

True or false are I and i antigens are antithetical antigens?

A

False, they are not anthithetical antigens

44
Q

What are P1PK antigens?

A

P1 and Pk

45
Q

What are the 3 phenotypes of P1PK?

A

P1, P2, and null (p)

46
Q

This antibody is found in P2 individuals, IgM; enhanced by ezymes, non-RBC stimulated and can be neutralized by P1 substance

A

Anti-P1

47
Q

This antibody is associated with cold paroxysmal hemoglobinuria, IgG (Donath-Landsteiner antibody) and may appear in children after viral infections?

A

Autonanti-P

48
Q

This antibody can occur in individuals with the null phenotype, causes hemolysis in vitro and is clinically significant

A

Anti-PP1Pk

49
Q

This is coded by Glycophorin A, differ positions on 1 and 5 and is on glycophorin A (GPA)

A

M and N

50
Q

This is coded by glycophorin B, differ at position 29

A

S, s, and U

51
Q

This antibody is most frequently found in dialysis patients that due to formaldehyde-sterilized instruments

A

Anti-N

Blood Banking (3 decks)

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