Chapter 7 - Mass Transport Flashcards
What does the affinity of haemoglobin for oxygen mean
- the ability of haemoglobin to attract, or bind, oxygen
What does the saturation of haemoglobin with oxygen mean
When haemoglobin is holding the maximum amount of oxygen it can bind
What does the loading/ association of haemoglobin mean
The binding of oxygen to haemoglobin
What does the unloading/ dissociation of haemoglobin
When oxygen detaches or unbinds from haemoglobin
What does the oxyhemoglobin dissociation curve show
That oxygen is loaded in regions of high partial pressure of oxygen and unloaded in regions if low partial pressure
Explain the positive cooperation of oxygen
at low partial pressure it is difficult for the first O2 molecule to bind to the haemoglobin so requires a large increase in partial pressure (hence why the graph is steep at first)
Once the first O2 molecule binds the quaternary structure of the haemoglobin, it changes in shape, which increases the affinity for the next oxygen to bind so binding the rest of the oxygen molecules only require a small increase in partial pressure (hence why the graph begins to level off)
What is the Bohr effect
When carbon dioxide concentration causes the oxyhaemoglobin curve to shift to the right. So the affinity for oxygen decreases because the carbon dioxide dissolves in the blood to form carbonic acid causing pH to decrease and these acidic conditions changes the shape of the haemoglobin slightly decreasing affinity and therefore unloads more oxygen
What effect will low CO2 conc have in the oxyhemoglobin affinity curve
Makes it shift to the left as the pH will increase as less H+ ions are released into the blood so the Shape of haemoglobin will change and oxygen affinity increases and therefore more oxygen is loaded
Explain the difference between fetal haemoglobin and adult haemoglobin
The fetal haemoglobin has a higher oxygen affinity than the adult haemoglobin as the foetus cannot inhale or exhale, so it’s source of oxygen comes from the mother haemoglobin in the blood supply, so the fetal haemoglobin has to have a high o2 affinity in order to take oxygen from the mother’s haemoglobin
Explain the difference between llama haemoglobin and human haemoglobin
Llamas live at high altitudes where there is a low partial pressure of oxygen compared to humans so has a higher oxygen affinity
Explain the difference between dove haemoglobin and human haemoglobin
Dove has a lower oxygen affinity compared to humans as they have a faster metabolism for aerobic respiration to provide for contracting muscle (so will produce more co2 causing their oxygen affinity to decrease)
Explain the difference between earthworms haemoglobin and human haemoglobin
- earthworms haemoglobin has a higher oxygen affinity than humans as they live underground where there is a low partial pressure of oxygen
Why do mammals have a double circulatory system
To mamaage the pressure if the blood flow
What does it mean by double circulatory system
That the blood passes through the heart twice in each circuit, with one circuit which delivers blood to the lungs and the other which delivers blood to the rest of the body
How does the closed double circulatory system work in mammals
1) the blood flows through the lungs at a lower pressure, this prevents damage to the capillaries in the alveoli and at low speed to enable more time for gas exchange
2) the oxygenated blood from the lungs then goes back through the heart to be pumped out at higher pressure to the rest of the body, this is important to ensure that the blood reaches all the respiring cells in the body
What are the key blood vessels
- coronary arteries
- pulmonary artery and vein (connected to lungs)
- renal artery and vein (connected to kidneys)
- vena cava, aorta, pulmonary artery and vein (connected to heart)
Role of coronary arteries
Supply heart with oxygenated blood
Properties of the cardiac muscle (thick muscular layer in heart)
- myogenic, meaning can contract and relax without needing any stimulation from the nervous system or hormones
- never fatigues as long as it has a supply for oxygen
What happened if coronary arteries become blocked
- can cause coronary heart disease as the coronary arteries won’t receive oxygen and therefore won’t be able to respire so the cells in cardiac muscles will die, resulting in myocardial infarction (a heart attack)
Properties of the left and right atria (atrium)
- elastic walls to stretch when blood enters
- thinner muscular wall than ventricular as they do not need to contact as blood is only pumping to ventricles and not to the whole body
Properties of the left and right ventricles
- thicker muscular walls to enable a bigger contraction, this creates a high blood pressure to enable blood to flow longer distances
Why does the right ventricle have a thinner muscular wall compared to the left ventrical
- As it Pumps blood to the lungs, so blood has to be at a low pressure to prevent damage to capillaries in the lungs and blood flows slowly allowing more time for gas exchange, this means that is has a thinner muscular wall compared to the left ventricle
Why does the left ventrical have thicker muscular walls compared to the right ventrical
The right ventricle has thinner muscular walls as it only needs enough pressure to pump deoxygenated blood a short distance to the lungs.
The left ventricle have thicker muscular walls to enable bigger contractions to create a lot of pressure to pump oxygenated blood to the other more distant organs of the body.
Role of vena cava
Carries deoxygenated blood from the body to the right atrium