CHAPTER 7: CARTILAGE Flashcards
a tough, durable form of supporting connective
tissue
Cartilage
characterized by an extracellular matrix (ECM) with
high concentrations of GAGs and proteoglycans,
interacting with collagen and elastic fibers.
Cartilage
consists of cells called chondrocytes embedded in
the ECM
Cartilage
physical properties depends on electrostatic bonds
between type II collagen fibrils, hyaluronan, and the
sulfated GAGs on densely packed proteoglycans
Cartilage
lack vascular supplies and chondrocytes receive
nutrients by diffusion from capillaries in surrounding
connective tissue
Cartilage
o Lacks nerves
Cartilage
3 TYPES OF CARTILAGE
Hyaline, Elastic, fibrocartilage
Synthesize and maintain all ECM components
Chondrocytes
located in matrix cavities
Chondrocytes
exhibit low metabolic activit
Lacunae
Young chondrocytes are called _________ which
have an elliptic shape, with the long axes parallel to
the surface
chondroblast
- chondrocyte found deeper
in cartilage and appear in groups
Isogenous Aggregates-
a sheath of dense connective tissue that surrounds
cartilage in most place
Perichondrium
forms an interface between the cartilage and the
tissues supported by the cartilage.
harbors the blood supply serving the cartilage
covers all hyaline cartilage except in articular
cartilage of joints
essential for the growth and maintenance of
cartilage
The outer region of the perichondrium consists
largely of _______ and fibroblasts
o inner layer adjoining the cartilage matrix also
contains ____________
collagen type I fibers
mesenchymal stem cells
avascular,
o Where the dry weight of hyaline cartilage is
embedded
generally basophilic and the thin collagen fibrils are
barely discernible.
o Composed of chondronectin a structural
multiadhesive glycoprotein which binds specifically
to GAGs, collagen, and integrins, mediating the
adherence of chondrocytes to the ECM.
Matrix
