Chapter 6 - Substance P & Endorphins Flashcards
What kind of substance is substance P?
Neuropeptide (chemical class PPP)
What is the function of substance P?
Transmit pain about tissues to the CNS
Substance P binds to what receptor?
Neurokinin-1
Where can substance P be found?
All organs of the body
Substance P acts as a neurotransmitter for what sensation/perception?
Pain and anxiety
What effect does substance P have on heart rate?
Increase
Does substance P act as a vasodilator or vasoconstrictor?
Vasodilator
What effect does substance P have on blood pressure?
Decrease
What effect does substance P have on the immune response?
Increase
What effect does substance P have on oxygen transport?
Increase
What effect does substance P have on cell growth?
Stimulation
Substance P increases the secretion of what hormones?
STH (cell growth), LTH, TSH, FSH, LH, ADH
Substance P is found in what kind of brain regions?
Those that regulate emotions
Substance P is released in what kind of local inflammatory response?
Neurogenic inflammation of certain injuries
Substance P is released from sensory nerve fibers in what specific areas?
Skin, muscles, and joints
What part of the brainstem has high concentrations of substance P?
Vomiting center of the medulla
Substance P has a role in inflammatory diseases of which body systems?
Respiratory, gastrointestinal, and musculoskeletal
Substance P is secreted by nerves and what inflammatory cells during inflammatory disease?
Macrophages and lymphocytes
What type of fibers are myelinated and respond to heat and touch?
A-delta fibers
What type of fibers are unmyelinated and respond to heat and touch?
C fibers
What type of fibers are thickly myelinated and respond to light touch?
A beta fibers