CHAPTER 6: CONTACT DERMATITIS AND DRUG ERUPTION Flashcards
Inflammatory reaction of the skin from exposure to a substance that causes eruptions No previous exposure necessary
Irritant contact dermatitis
Acquired sensitivity to various substances that produce inflammatory reactions only in persons who have been previously sensitized
Allergic contact dermatitis
Pain and burning more common in this type of contact dermatitis
Irritant
Alkalis penetrate and destroy deeply because they:
Dissolve keratin
Principal compounds in alkalis
Sodium, Potassium, Ammonium, Ca hydroxide
Powerful acids are _______________ whereas weaker acids are ________________
A. Astringent B. Corrosive
B A
What type of acid produces a brownish charring of the skin, beneath which is an ulceration that heals slowly
Sulfuric acid
This acid is used more widely than any other acid in industry
Sulfuric acid
This acid causes deep burns Tissue is stained yellow
Nitric acid
One of the strongest inorganic acids, capable of dissolving glass
Hydrofluoric acid
___ may produce paresthesia of the fingertips, with ing agents when possible, and protection, most often by
cyanosis and gangrene. The nails become discolored yellow
OXALIC ACID
This acid is used in the manufacturing of pigments
Titanium hydrochloride
What to do if you come in contact with titanium hydrochloride
Application of water to the Alkalis
exposed part will produce severe burns. Therefore, treatment
consists only of wiping away the noxious substance.
is a protoplasmic poison that pro- cleaners, and toilet bowl and oven cleansers. Alkalis penetrate
duces a white eschar on the surface of the skin.
Phenol (carbolic acid)
. . .
readily neutralized
with 65% ethyl or isopropyl alcohol.
Acid in tear gas (lacrimators) that can cause dermatitis
Chloroacetophenone
Petrolatum dermatitis from impure petroleum jelly or lubricating oil manifests as
Verrucous thickening of skin
What type of hypersensitivity Allergic contact dermatitis
it is caused by a spe- cific acquired hypersensitivity of the delayed type, also known as :
cell-mediated (type IV) hypersensitivity.
Application of substances suspected to be the cause to intact uninflamed skin usually on upper back
Patch test
Patches in patch test are removed after_____ and reevaluated after ______
48 hours ;Day 4 or 5
In photopatch test, a standard patch test is applied for 48h then exposed to ______ J/m2 of UVA and read after another 48 hours
5-15
Most frequent site for nail polish dermatitis
Eyelids
Earlobe dermatitis is indicative of sensitivity from ______
Nickel
Deodorant and clothing dye can cause dermatitis in the axillary area. Which part of the axilla is involved in what substance?
Deodorant-axillary vault Clothing dye- axillary fold
Most common cause of allergic contact dermatitis in florists
Peruvian lily
Difference between dermatitis and fungal infection on the foot
Toe webs involved in fungal infections
Dermatitis from metals is usually due to
Nickel and chromates
Most common cause of allergic contact dermatitis in children and adults
Nickel
Leading cause of allergic contact dermatitis associated with cosmetics
Fragrance
Chemical in hair dye that can cause dermatitis
Phenylenediamine
Hair bleaches contain ________ that can cause dermatitis
Ammonium persulfate
Chemical found in most so called natural products that is an allergen
Propolis
Most common sunscreen allergen
Oxybenzone
Least irritating antiperspirant
Aluminum chlorhydrate
Which drug induces the highest rate of allergic reactions
Clonidine
Produce sensitization of skin when applied topically, when ingested, an acute flare at site of contact dermatitis may occur
Anamnestic (recalled) eruption
Most common topical local anesthetic that can cause dermatitis
Benzocaine
Antibiotics that most commonly cause dermatitis
Neomycin Bacitracin