CHAPTER 19: VIRAL DISEASES Flashcards
part of the virus that etermines serologic specificity, protects the nucleic acid from enzymatic degrada- tion in biologic environments, controls host specificity, and increases the efficiency of infection.
protein coat ( capsid)
few eroded follicular papules (resembling acne excoriée) to extensive lesions involving the whole beard area in men
caused by HSV -1 infection
Herpetic sycosis
Infection with HSV-1 is highly contagious to susceptible persons who wrestle with an infected individual with an active lesion.
Herpes gladiatorum
occur on the fingers or periungually
Lesions begin with tenderness and erythema, usually of the lateral nailfold or on the palm.
Deep-seated blisters develop 24–48 h after symptoms begin
Herpetic whitlow
causative agent of orolabial herpes?
HSV 1
causative agent of genital herpes?
HSV 2
MOT of genital herpes
Genital herpes is spread by skin-to-skin contact, usually during sexual activity.
describe the lesions of genital herpes
lesions are classic, grouped blisters on an erythematous base
tx for neonatal herpes
IV acyclovir for 14 days for SEM ( skin, eyes and/or mouth infection);
21 days for CNS and dessiminated dse
management for pregnant women with genital herpetic leisons or prodromal sx?
acyclovir 400 mg TID PO x 10 days ( except in the first month of gestation).
Caesarian section ( scalp electrode and vacuum assisted delivery is CI )
Infection with herpesvirus in patients with atopic dermatitis (AD) may result in spread of herpes simplex throughout the eczematous areas, called
eczema herpeticum (EH) or Kaposi varicelliform eruption (KVE).
3 clinical hallmarks of HSV infection
- pain
- active vesicular border
- scalloped periphery
what is the standard treatment for acyclovir-resistant herpes simplex
IV foscarnet
IV Cidofovir for Foscarnet resistant herpes simplex
most characteristic feature of HSV infection histologically
**multinucleated giant cells, ** molding together, forming a crude **jigsaw puzzle appearance. **
incubation period of VZV
10-21 days
MOT of VZV
respiratory route and less often by direct contact w/ the lesion
treatment of genital herpes
oral acyclovir, 200 mg five times or 400 mg three times daily; famciclovir, 250 mg three times daily; or valacyclovir, 1000 mg twice daily, all for 7–10 days.
when is Varicella most infetious?
infectious from 5 days BEFORE the eruption appears and are most infectious 1–2 days BEFORE the rash appears.
when does varicella ceases its infectivity?
Infectivity usually ceases 5–6 days after the erup- tion appears.
“teardrop” vesicles on an erythematous base
Varicella
most common neurologic com- plications of varicella
Cerebellar ataxia and encephalitis
what drug is commonly CI in varicella?
aspirin and other salicylates
risk of reye syndrome
treatment of varicella
acyclovir 20 mg/kg, maximum 800 mg per dose, four times daily for 5 days.
neonatal varicella can occur if the mother develops varicella when?
If the mother develops varicella between 5 days BEFORE and 2 days AFTER delivery
management of varicella in pregnant women
oral acyclovir, 800 mg five times daily for 7 days, except perhaps during the first month.
> /= 35 weeks of gestation or with increased risk of premature labor: admission and IV acyclovir, 10 mg/kg three times daily
VZIG is recommended in pregnant women when?
there is significant exposures within the first 72–96 h
(VZIG) should not be given once the pregnant woman has developed varicella.
Children immunized with live attenuated varicella vaccine may develop varicella of reduced severity on exposure to natural varicella. This has been called
modified varicella-like syndrome (MVLS)
VZV remains latent in ___
sensory dorsal root ganglion cells.
the dermatomes most frequently affected of VZV are:
the thoracic (55%), cranial (20%, with the trigeminal nerve being the most common single nerve involved), lumbar (15%), and sacral (5%).
what nerve is involve in herpes zoster ophthalmicus?
ophthalmic division of the fifth cranial nerve