Chapter 6 Flashcards
How many Heme Sites Does Hemoglobin Have?
4
How many chains does Globin have that can undergo Mutations?
- Two a Chains
- Two b Chains
What is Ferrous Iron? What happens when it is Oxidized?
Ferrous Iron
- Found on Adult hemoglobin A
Oxidized
- Becomes Ferric Iron
- Release of Oxygen to tissue is impaired
What does Fetal Hemoglobin F have? What does it help with?
Has
- High Oxygen Affinity
Use
- Helps Fetus tolerate hypoxic environment in Utero
What does Dissolved Oxygen Obey?
Henry’s Law
What is Henry’s Law?
- The amount of gas dissolved is proportional to the partial pressure
What is the ratio of O2 dissolved in 100ml of blood to PO2?
For each mmHg of PO2, 0.003ml O2 dissolved per 100ml of blood.
What is the normal arterial O2 Content?
0.3ml O2/100ml
What is the amount of dissolved O2 in Normal Arterial Blood with a Q= 50L/min?
0.3ml O2/100ml (normal Arterial Blood)
3ml/1L x 50L/min = 150ml/min O2
What is O2 Capacity?
- The maximum amount of O2 that can be combined with Hb.
How much O2 can 1g of Hb combine with?
1.39ml O2
How much Hb does normal blood have?
- 15g of Hb/ 100ml
What is the O2 Capacity of Blood?
- 20.8ml O2/ 100ml blood
What is the equation for O2 Saturation of Hb?
O2 Saturation of Hb = ((O2-Hb) / O2 Capacity) x 100
What is the normal SaO2 of Arterial Blood?
- 97.5%
What is the normal SaO2 of Venous Blood?
- 75%
What is the Equation to find the O2 Concentration of Blood (ml O2 / 100ml Blood)?
(1.39 x Hb x Sat/100) + 0.003Po2
What are the 5 steps that the Oxygen Transport System Cycles Between?
- Pulmonary Ventilation
- Hemoglobin Concentration
- Blood Volume and Cardiac Output
- Peripheral Blood Flow
- Aerobic Metabolism
What is the Equation for identifying VO2? (Oxygen Usage)
VO2 = Q x a-vO2 difference
What are the Useful Anchor Points of the Oxygen Dissociation Curve?
- PO2 40 has a SO2 of 75%
- PO2 100 has a SO2 of 97%
- P50 has a PO2 of 27 and SO2 of 50%