Chapter 6 Flashcards
Skeletal System
Components include:
- Bones of the skeleton
- Cartilages, joints, ligaments, connective tissue that stabilize or connect bones
Functions of the Skeletal System
- Support
-Provides structural support for the entire body
-Bones provide attachments for soft tissues and organs - Storage of minerals and lipids
-Mineral reserves for calcium and phosphorus ions held in calcium salts in bone
-Yellow bone marrow stores lipids for energy reserves - Blood cell production
-Red blood cells, white blood cells, and other blood elements produced in the red bone marrow - Protection
-Soft tissues and organs are surrounded by skeletal structures
Examples:
-The skull encloses the brain
-The ribs protect the heart and lungs - Leverage
-Bones function as levers
-Change size and direction of force generated by skeletal muscles
-Result is body movement
Bone or osseous tissue
-Supporting connective tissue containing cells in a matrix
-Cells are called osteocytes
Matrix contains:
-Calcium salts in the form of calcium phosphate, Ca3(PO4)2
-Accounts for almost 2/3 of the weight of bone
Extracellular protein fibers
-About 1/3 of bone weight comes primarily from collagen fibers
Classifying bones by shape
- Bones of the skeleton are categorized into four general shapes
1. Long bones - Longer than they are wide
2. Short bones - About as wide as they are long
3. Flat bones - Thin and relatively broad
4. Irregular bones - Complex shapes that don’t fit another category
Features of a Long Bone
- The diaphysis is the central shaft
- Surrounds a marrow cavity, or medullary cavity, in the center filled with bone marrow
- The epiphyses are the expanded portions at each end
- Covered with articular cartilage
- Articulate with an adjacent bone at a joint
Types of Bone Tissue in a Long Bone
- Compact bone, or dense bone
- Relatively solid
- Forms the wall of the diaphysis
- Spongy bone, or cancellous bone
- Interlacing network of bony rods separated by spaces
- Fills the epiphyses
- Lines the marrow cavity
Coverings of a Long Bone
- Outer surface covered by periosteum
- Inner cellular layer
- Outer fibrous layer
- Isolates bone from surrounding tissue
- Forms attachments with fibers of tendons and ligaments
- Inner surfaces and spongy bone of marrow cavity covered by endosteum
- Functions during bone growth and repair
Microscopic Features of Bone
- Bone cells are called osteocytes
- Located in pockets called lacunae
- Found between sheets of calcified matrix called lamellae
- Canaliculi are small channels
- Contain cytoplasmic extensions of the osteocytes
- Radiate through the matrix
- Connect the lacunae to blood vessels for nutrient and waste exchange
Histology of Compact Bone
- Basic functional unit is the osteon, or Haversian system
- Osteocytes arranged in concentric layers (lamellae)
- Layers surround a central canal, or -Haversian canal
- Central canals run parallel to surface of bone and contain blood vessels
Perforating canals
Link blood vessels of central canal with blood vessels of periosteum and marrow cavity
Characteristics of Compact Bone
- Covers all bone surfaces except inside joint capsules
- Articular cartilage protects opposing bone surfaces here
- Parallel arrangement of osteons resists stress in specific direction
- Withstands forces applied on either end of a long bone
- Cannot tolerate moderate stress applied to the side of the shaft
Structural Features of Spongy Bone
- Has no osteons
- Lamellae form rods or plates called trabeculae
- Still contains osteocytes, lacunae, and canaliculi
- Contains red bone marrow
- Found in spaces between trabeculae
Functional Features of Spongy Bone
Found in:
-Locations not heavily stressed
-Locations with stresses arriving from many different directions
Example: epiphyses of long bones where stresses transferred across joints
-Much lighter than compact bone
-Reduces weight of the skeleton
-Easier for muscles to move bones
Osteoblasts
Produce new bone through a process called ossification
Osteocytes
- Most abundant cells in bone
- Mature cells that maintain bone structure by recycling calcium salts
Osteoclasts
- Secrete acid and enzymes that dissolve the matrix
- Process releases minerals through osteolysis, or resorption
Bone Formation
-Embryonic development of bone
-Begins at week 6 as a cartilaginous formation
-Replaced with bone, a process called ossification
Two types
1. Intramembranous ossification
2. Endochondral ossification
Calcification occurs during ossification
-Can also occur in other tissues besides bone
Intramembranous Ossification
- Occurs during fetal development
- Bone develops within sheets of connective tissue
- Begins in an ossification center
- Osteoblasts differentiate from connective tissue stem cells and form new bone matrix
- Bone matrix formation extends outward
- Osteoblasts surrounded by matrix change into osteocytes
- Blood vessels grow into area and are trapped within developing bone
- Bone remodeling produces osteons of compact bone
- Flat bones of skull formed in this manner
Endochondral Ossification
-Process of formation for most bones of the skeleton
-Begins with hyaline cartilage models
-Cartilage replaced by true bone in five steps
Steps 1–3 of Endochondral Ossification
1. Chondrocytes enlarge and surrounding matrix begins to calcify
-Chondrocytes die from lack of nutrients
Calcification of matrix slows diffusion
2. Bone formation starts at the shaft surface
-Blood vessels grow around edges
-Cells of perichondrium differentiate into osteoblasts
-Osteoblasts produce bone matrix around shaft surface
3. Blood vessels invade inner region of cartilage
-Migrating fibroblasts differentiate into osteoblasts
-New osteoblasts form spongy bone in center of shaft at the primary ossification center
-Bone develops toward each end filling shaft with spongy bone
4. Osteoclasts begin to break down spongy bone in center of bone
-Forms marrow cavity
-Epiphyseal cartilages, or epiphyseal plates, on the ends of the bone continue to enlarge
-Increases length of the bone
5. Centers of the epiphyses begin to calcify
-Secondary ossification centers form as blood vessels and osteoblasts enter
-Epiphyses fill with spongy bone
-Thin layer of original cartilage covers joint surfaces as the articular cartilage Bone of shaft and epiphysis separated by epiphyseal
Epiphyseal Line
- At puberty, bone growth accelerates due to increased sex hormone production
- Osteoblasts produce bone faster than the epiphyseal cartilage can expand
- Epiphyseal cartilages get narrower until disappear
- Called epiphyseal closure
- X-rays of adult bones show former location of epiphyseal cartilage as epiphyseal line
Appositional Growth
- Growth in diameter of bones occurs along with growth in length
- Process of growing in diameter is appositional growth
- Periosteum cells develop into osteoblasts
- Produce more matrix on the outer surface of the bone
- Osteoclasts erode the inner surface
- Marrow cavity enlarges as a result
Timing of Epiphyseal Closure
- Varies from bone to bone
- Digits close early
- Arm, leg, and pelvis bones close later
- Varies from person to person
- Different timing in males versus females
- Mostly due to differences in sex hormones
- Later closure in males
Requirements for Bone Growth (Mineral Supply)
- Calcium salts (calcium and phosphate)
- Absorbed from mother’s bloodstream during prenatal development
Requirements for Bone Growth (Vitamin D3)
- Plays role in calcium metabolism
- Liver and kidney process into calcitriol that stimulates calcium and phosphate absorption
- Manufactured by epidermal cells exposed to UV radiation
- Also obtained from dietary supplements
- Deficiency leads to softening of bones
- Condition called osteomalacia in adults and rickets in children
Requirements for Bone Growth (Vitamin A and C)
- Provide support for osteoblasts
- Various hormones
- Growth hormone
- Thyroid hormone
- Sex hormones
- Calcium-balancing hormones
Bone Remodeling Process
- Remodeling process recycles and renews organic and mineral components of bone matrix
- Osteocytes maintain matrix, continually removing and replacing calcium salts
- Osteoclasts continually remove matrix
- Osteoblasts continually build matrix
- Normally activity is balanced
Role of Bone Remodeling
- Turnover of minerals gives bone ability to adapt to new stresses
- Heavily stressed bones are thicker and stronger
- Regular exercise important to maintaining bone structure
- Bones receiving lower than normal stress are thinner and more brittle
- Inactivity (such as using crutches) results in loss of bone mass
Rate of Bone Remodeling
- Rate of remodeling varies with age and type of bone
- In young adults, nearly 1/5 of the skeleton is recycled and replaced each year
- Spongy bone remodeled more frequently than compact
- Spongy bone in head of femur replaced 2–3 times per year
- Compact bone of femur shaft largely untouched
Skeleton as a Calcium Reserve
-Calcium is the most abundant mineral in the body
-99% of calcium is deposited in the skeleton
-Essential mineral for many physiological processes
Examples: neuron and muscle cell function
-Very close regulation required
-Small changes in calcium ion concentrations affect cellular function
-Larger changes can cause convulsions and death
-Calcium balance is regulated by:
Parathyroid hormone (PTH) and calcitriol to raise calcium levels
-Calcitonin to lower calcium levels in body fluids
Fracture Naming
- Fracture is a crack or break in a bone
- Two broad categories based on external appearance
- Closed (simple) fractures
- Completely internal (no break in the skin)
- Can be seen only on x-rays
- Open (compound) fractures
- Project through the skin
- More dangerous due to risk of infection
- Fractures also named by nature or location of the break
Four Steps to Repair Fractures
- Large blood clot, or fracture hematoma, forms.
- Closes off the injured blood vessels
- Lack of blood flow kills osteocytes, resulting in dead bone extending on either side of the fracture - Cells of periosteum and endosteum divide and migrate into fracture area
- Internal callus of spongy bone unites inner edges of fracture
- External callus of cartilage and bone stabilizes outer edges of fracture - Osteoblasts replace cartilage with spongy bone
- Spongy bone is replaced by compact bone
- Leaves slightly thicker spot at the fracture site
Osteopenia and Aging
Bones become thinner and weaker as normal part of aging
Osteopenia
- Inadequate ossification that naturally occurs as part of the aging process
- Begins between ages 30 and 40
- Osteoblast activity slows
- Osteoclast activity remains constant
- Women lose about 8% of skeletal mass each decade
- Men lose about 3% of skeletal mass each decade
Osteoporosis
- Loss of bone mass that impairs normal function and can lead to more fractures
- More severe than normal osteopenia
- Condition is more common in women
- Process accelerates after menopause
- Due to a decline in circulating estrogen
- Condition less common in men due to levels of androgens (male sex hormones)
- Causes increased bone fractures and decreased ability to repair
Bone Markings
- Landmark features on the surfaces of bones are called bone markings or surface features
- Elevations or projections
- Where tendons and ligaments attach
- Where bones articulate
- Depressions, grooves, and openings
- Where blood vessels and nerves pass through the bone
Skeletal Divisions
- Skeletal system consists of 206 bones
- Can be divided into two divisions
1. Axial skeleton
2. Appendicular skeleton
Axial Skeleton
- Forms longitudinal axis of body
- Contains 80 bones subdivided into:
1. Skull bones (22)
2. The bones associated with the skull (6 auditory ossicles and the hyoid bone)
3. Bones of the thoracic cage (25)
4. Bones of the vertebral column (26)
Appendicular Skeleton
- Bones of the pectoral girdle and upper limbs
- Bones of the pelvic girdle and lower limbs
Functions of the Axial Skeleton
- Creates framework for support and protection of the brain, spinal cord, and organs in the ventral body cavity
- Provides surface area for attachment of muscles that:
1. Move the head, neck, and trunk
2. Perform respiration
3. Stabilize elements of the appendicular skeleton
The Skull
-Protects the brain
-Houses brain and sense organs for sight, smell, taste, hearing, and balance
-Made up of 22 bones
8 form the cranium
-Encloses cranial cavity, chamber supporting the brain
-14 are facial bones
Bones Associated with the Skull
-Seven bones associated with the skull 6 auditory ossicles (ear bones) -Encased by the temporal bone -Involved with sound detection -Hyoid bone -Connected to inferior skull by pair of ligaments
The Frontal Bone
- Forms the forehead and the roof of the orbits, or eye sockets
- Supraorbital foramen (or notch)
- Forms a passageway above each orbit for blood vessels and nerves
- Frontal sinuses
- Air-filled cavities above the orbit
- Lined with mucous membrane
- Connect with the nasal cavity
- Reduce weight of the bone
The Parietal Bones
- Paired bones located posterior to frontal bone
- Form the roof and superior walls of the cranium
- Interlock along the midline of the cranium forming the sagittal suture
- Articulate with frontal bone along coronal suture
The Occipital Bone
-Forms the posterior and inferior portions of the cranium
-Articulates with two parietal bones at the lambdoid suture
-Foramen magnum
-Passageway surrounding the connection between the brain and the
spinal cord
-Occipital condyles
-Rounded surfaces on either side of the foramen magnum
-Articulate with the first vertebra
The Temporal Bones
- Form part of both sides of the cranium and zygomatic arches
- Articulate with the parietal bones at the squamous suture
- House the auditory ossicles in middle ear
Key bone markings
- External acoustic (or auditory) meatus
- Mandibular fossa
- Mastoid process
- Styloid process
The Sphenoid Bone
- Forms part of the floor of the cranium
- Acts as bridge, uniting cranial and facial bones
- Braces sides of skull
- Contains pair of sinuses (sphenoidal sinuses)
- “Wings” of the bone extend laterally from a central depression, the sella turcica
- Depression houses and protects the pituitary gland
The Ethmoid Bone
- Anterior to the sphenoid
- Forms part of the cranial floor
- Contributes to medial surfaces of the eye orbits and forms roof and sides of the nasal cavity
- Ridge called crista galli (“cock’s comb”) projects above superior surface
- Holes in cribriform plate allow olfactory nerves to pass through, carrying sense of smell
- Contains ethmoidal sinuses in lateral portions
Superior and middle nasal conchae
- Project into nasal cavity toward nasal septum
- Slows airflow, allowing time to clean, moisten, and warm air before entering respiratory tract