Chapter 59

Question 1

Does magnesium or aluminum cause diarrhea?

Answer 1

magnesium

Question 2

What are the two mechanisms by which gastrin promotes acid secretion?

Answer 2

1. stimulates ECL release

2. directly activates parietal cells

Question 3

What causes D-cell to release somatostatin?

Answer 3

H+

Question 4

Which gastric cells have receptors for Ach? Which isotypes?

Answer 4

ECL = M1

Parietal = M3

Question 5

What metal is contained in sucralfate?

Answer 5

aluminum

Question 6

What specific prostaglandin is misoprostol an analogue of?

Answer 6

PGE1

Question 7

What is the three drug cocktail to treat H. pylori?

Answer 7

PPI

clathiromycin

amoxicillin/metronidazole

Question 8

What are the two GI D2 antagonists?

Answer 8

metoclopramide and domperidone

Question 9

What are the two mu-opioid agonists used to treat diarrhea?

Answer 9

Loperamide and Diphenoxylate

Question 10

What drug is contained in Diphenoxylate?

Answer 10

atropine

Question 11

What are the two mu-opioid antagonists used to treat constipation?

Answer 11

Methylnaltrexone and Alvimopan

Question 12

What are the two anti-muscarinics used in the Tx of IBS?

Answer 12

Dicyclomine

Hyoscamine

Question 13

Which 5HT3 antagonist is used in women?

Answer 13

Alosetron

Question 14

What drug used to treat constipation is a chloride channel activator?

Answer 14

lubiprostone

Question 15

What cytochrome enzyme does aprepitant inhibit?

Answer 15

CYP3A4

Question 16

Which monoclonal antibody blocks integrins on circulating leukocytes?

Answer 16

natalizumab