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Katzung Trevor Pharm > Chapter 54 > Flashcards

Chapter 54 Flashcards

1
Q

What drug is used to rescue methotrexate?

A

leucovorin

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2
Q

What drug is used to rescue cyclophosphamide?

A

mesna

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3
Q

What drug is used to rescue doxorubicin?

A

Dexrazoxane

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4
Q

Which anti-neoplastic produces hydrogen peroxide as its MOA?

A

Procarbazine

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5
Q

Does methotrexate lead to the decrease in synthesis of purines of pyrimidines?

A

purines

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6
Q

What enzyme degrades 6-MP?

A

allopurinol

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7
Q

What phase of the cell cycle do the vinca alkaloids inhibit?

A

S-phase

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8
Q

What is MOA of vinca alkaloids?

A

prevent assembly of mitotic spindle

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9
Q

What is MOA of paclitaxel and docetaxel?

A

prevent disassembly of mitotic spindle

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10
Q

Which anti-neoplastic is fatal during G2?

A

bleomycin

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11
Q

What receptor does cituximab target?

A

EGFR

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12
Q

What cancer is erlotinib used to treat?

A

metastatic small cell lung

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Katzung Trevor Pharm (16 decks)

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