Chapter 50 Flashcards
What are the two types of PNS disorders?
Neuromuscular
Cranial nerve disorders
What does the PNS involve?
The nerves of arms, legs, chest, abdomen
What are the 4 neuromuscular disorders we are talking about?
MS
Myasthenia Gravis
ALS
Gullian-Barre Syndrome
What do the neuromuscular disorders do?
They disrupt the transmission of impulses between neurons and the muscles they stimulate
What is the myelin sheath?
It covers the axons and is responsible for the smooth transmission of nerve impulses
What is MS?
involves the degeneration of myelin sheath
How can the myelin sheath be damaged?
It can be damaged due to inflammation, detachment or if it becomes swollen
How can myelin repair itself?
exacerbation followed by remission
What is the etiology of MS?
Unknown, could be possible autoimmune response, possible viral infection, or heredity
What are the two types of MS?
Relapsing remitting and progressive
What is relapsing remitting MS?
Worsening signs and symptoms followed with improvement
What is progressive MS?
gets worse without improvement
What is the most common type of MS?
relapsing remitting
What are some problems associated with MS? (S/S)
Weakness/paralysis of limbs Double/blurred vision Slurred speech Spasticity of muscles Numbness Tinnitus and vertigo Dysphagia Spastic or flaccid bladder Mood swings
What do the symptoms depend on for MS?
The symptoms depend on the area with the sclerosed myelin
What are some different factors that can trigger the onset of symptoms of MS?
Extreme heat, extreme cold, fatigue, infection and emotional stress
How does death usually occur in MS?
death usually results from infection
Therapeutic interventions for MS?
Steroids Immunosuppressants Anticonvulsants Muscle relaxants PT/OT
What is acetylcholine needed for?
Muscle contraction
What happens during myasthenia gravis?
If there is no acetylcholine or the receptors for acetylcholine are destroyed, the muscle contraction doesn’t take place
The muscle weakness in myasthenia gravis occurs during activity and improves with ____
rest
Myasthenia gravis affects ?
facial muscles, neck and limb movement
S/S of myasthenia gravis?
Progressive muscle weakness Fatigue with activity Ptosis Difficulty chewing and swallowing Difficulty breathing An early sign can be double vision or slurred speech
What is a myasthenic crisis?
Sudden onset of symptoms due to not enough medication or triggered by infection
What are two complications of myasthenia gravis?
Aspiration
Respiratory infection and failure
How does a cholinergic crisis occur?
Due to overmedication
What two meds are given for myasthenia gravis?
Anticholinesterase drugs
Corticosteroids
Why are corticosteroids given for myasthenia gravis?
Inhibit the immune system and the production of abnormal antibodies
Why are anticholinesterase drugs given for myasthenia gravis?
Help improve nerve-muscle communications and increase the muscle strength
What is a tension test that is used to diagnosed myasthenia gravis?
Anicholinergic med is given and there is a temporary improvement of droopy eyelids (ptosis). It is an injection of tensilon and muscle strength improves for 1-3 mins
Why would you remove the thymus as a therapeutic intervention for myasthenia gravis?
This will work on the immune system so it doesn’t work against the body
How are meds used as a therapeutic intervention for myasthenia gravis?
They improve neuromuscular transmission and increase muscle strength. They also slow down the time of acetylcholine breakdown
What is ALS (amyotrophic lateral sclerosis)
Motor neurons degenerate (they stop sending messages and nerve impulse transmission is then blocked)
This results in muscle weakness and atrophy
As ALS progresses, it effects the muscles that control ____ and ____
breathing, swallowing
What is the etiology for ALS?
Unknown, but it may be due to possible genetic disposition or possible auto-immune disorder
ALS does NOT effect the brain, only ?
motor neurons
ALS causes what?
both the upper and lower motor neurons that control voluntary movement to die off.
This then leads to weakness, muscle death and then paralysis
What is pulmonary compromise in ALS?
This is when the muscles of the diaphragm are effected. They eventually end up on a ventilator
When does death usually occur after diagnosis of ALS?
3-5 years