Chapter 5 - Lymphoid Cells and the Monocyte-Macrophage Series Flashcards
- The undifferentiated cells from which all other specialized cells in the blood develop
HEMATOPOIETIC STEM CELLS
- Enzyme carried by the lymphoid stem cells in the BM which decreases along further differentiation and is lost in the thymus medulla
TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE (Tdt)
- Part of the thymus containing majority of immature proliferating thymocytes
CORTEX
- Other term for common thymocyte
INTERMEDIATE THYMOCYTE
- The pan-T markers
CD2 and CD7
- CD marker of t-cell that appears at an early stage and persists on mature T-cells
CD5
- CD marker first expressed in the cytoplasm of Stage 1 cells and is expressed simultaneously on the surface with TCR-1 and 2
CD3
- A rapid immune response against an antigen due to previously encountered antigen
ANAMNESTIC RESPONSE
- Surface marker responsible for resetting of SRBC in the E-rosette assay, thus known as SRBC receptor
CD2
- Functions as the antigen recognition site for T-cells
TCR
- Responsible for intracellular signaling to initiate an immune response once the T-cell has interacted with the antigen
CD3
- Soluble peptide mediators released by T-cells when triggered by antigens
LYMPHOKINES
- CD4 T-cells are restricted to what class of MHC molecules
CLASS II MHC MOLECULES
- All T-cell subsets are CD4 except ____
CYTOTOXIC T-CELL
T-helper cell subset that functions as an inducer cell for cytotoxicity, local inflammatory reactions and secretion of gamma interferon
Th1
- T-helper cell subset that directs the immune response toward production of IgE, IgA, and IgG1
Th2
- Th cells primarily act on what cells
B CELLS
- Other name of cytotoxic t-cell
CYTOLYTIC THYMUS-DEPENDENT LYMPHOCYTES (CTLs)
- Inducer T lymphocytes are similar in function with Th cells except with the cells that they activate or act on. Inducer T-cell activate what cells?
Th, Ts, Tc, and macrophages
- This T-cell subset interferes with the development of an immune response by acting directly on the cell or releasing suppressor factors
Supressor t-cell
- T-cell subset responsible for Gell and Coombs Type IV delayed hypersensitivity reaction
TDTH
- What is a virgin B cell?
NEWLY MATURED B CELL
- Part of the BCR and functions as an antigen recognition site and binds specific epitopes of antigen
SURFACE MEMBRANE IMMUNOGLOBULINS (SMIg)
B-cell receptor for activated complement component, most notably C3b
C3 RECEPTOR
Virus that can bind B-cells and frequently trigger immortalization with the development of a stable continually replicating line of B-cell
What is the receptor responsible for this attachment?
Epstein-Barr virus (EBV)
C3d receptor (CD21 molecule or complement receptor type 2 [CR2])
CD marker clinically used to enumerate B-cells in blood
CD19
B-cell CD marker required for class switch (of antibody) signals from T-cells
CD40
