Chapter 5 - Lymphoid Cells and the Monocyte-Macrophage Series

Question 1

1. The undifferentiated cells from which all other specialized cells in the blood develop

Answer 1

HEMATOPOIETIC STEM CELLS

Question 2

2. Enzyme carried by the lymphoid stem cells in the BM which decreases along further differentiation and is lost in the thymus medulla

Answer 2

TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE (Tdt)

Question 3

3. Part of the thymus containing majority of immature proliferating thymocytes

Answer 3

CORTEX

Question 4

4. Other term for common thymocyte

Answer 4

INTERMEDIATE THYMOCYTE

Question 5

5. The pan-T markers

Answer 5

CD2 and CD7

Question 6

6. CD marker of t-cell that appears at an early stage and persists on mature T-cells

Answer 6

CD5

Question 7

7. CD marker first expressed in the cytoplasm of Stage 1 cells and is expressed simultaneously on the surface with TCR-1 and 2

Answer 7

CD3

Question 8

8. A rapid immune response against an antigen due to previously encountered antigen

Answer 8

ANAMNESTIC RESPONSE

Question 9

9. Surface marker responsible for resetting of SRBC in the E-rosette assay, thus known as SRBC receptor

Answer 9

CD2

Question 10

10. Functions as the antigen recognition site for T-cells

Answer 10

TCR

Question 11

11. Responsible for intracellular signaling to initiate an immune response once the T-cell has interacted with the antigen

Answer 11

CD3

Question 12

12. Soluble peptide mediators released by T-cells when triggered by antigens

Answer 12

LYMPHOKINES

Question 13

13. CD4 T-cells are restricted to what class of MHC molecules

Answer 13

CLASS II MHC MOLECULES

Question 14

14. All T-cell subsets are CD4 except ____

Answer 14

CYTOTOXIC T-CELL

Question 15

T-helper cell subset that functions as an inducer cell for cytotoxicity, local inflammatory reactions and secretion of gamma interferon

Answer 15

Th1

Question 16

16. T-helper cell subset that directs the immune response toward production of IgE, IgA, and IgG1

Answer 16

Th2

Question 17

17. Th cells primarily act on what cells

Answer 17

B CELLS

Question 18

18. Other name of cytotoxic t-cell

Answer 18

CYTOLYTIC THYMUS-DEPENDENT LYMPHOCYTES (CTLs)

Question 19

19. Inducer T lymphocytes are similar in function with Th cells except with the cells that they activate or act on. Inducer T-cell activate what cells?

Answer 19

Th, Ts, Tc, and macrophages

Question 20

20. This T-cell subset interferes with the development of an immune response by acting directly on the cell or releasing suppressor factors

Answer 20

Supressor t-cell

Question 21

21. T-cell subset responsible for Gell and Coombs Type IV delayed hypersensitivity reaction

Answer 21

TDTH

Question 22

22. What is a virgin B cell?

Answer 22

NEWLY MATURED B CELL

Question 23

23. Part of the BCR and functions as an antigen recognition site and binds specific epitopes of antigen

Answer 23

SURFACE MEMBRANE IMMUNOGLOBULINS (SMIg)

Question 24

B-cell receptor for activated complement component, most notably C3b

Answer 24

C3 RECEPTOR

Question 25

Virus that can bind B-cells and frequently trigger immortalization with the development of a stable continually replicating line of B-cell

What is the receptor responsible for this attachment?

Answer 25

Epstein-Barr virus (EBV)

C3d receptor (CD21 molecule or complement receptor type 2 [CR2])

Question 26

CD marker clinically used to enumerate B-cells in blood

Answer 26

CD19

Question 27

B-cell CD marker required for class switch (of antibody) signals from T-cells

Answer 27

CD40